Detailed information NTG1137764

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQM50_RS03640
• Genome accession: NZ_LS483347
• Coordinates: 676449..677486 (+)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain NCTC8324
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 671449..682486

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM50_RS03615 (NCTC8324_00726)	-	671712..673043 (+)	1332	WP_011184765.1	dipeptidase	-
DQM50_RS03620 (NCTC8324_00727)	arcC	673063..674013 (+)	951	WP_010922501.1	carbamate kinase	-
DQM50_RS03625 (NCTC8324_00728)	asnA	674327..675319 (+)	993	WP_023611792.1	aspartate--ammonia ligase	-
DQM50_RS03630 (NCTC8324_00729)	rsmD	675442..675981 (+)	540	WP_111688439.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQM50_RS03635 (NCTC8324_00730)	coaD	675971..676462 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQM50_RS03640 (NCTC8324_00731)	sepM	676449..677486 (+)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
DQM50_RS03645 (NCTC8324_00732)	-	677900..678877 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQM50_RS03650 (NCTC8324_00734)	-	679325..679945 (+)	621	WP_002992791.1	YutD family protein	-
DQM50_RS03655 (NCTC8324_00735)	rlmN	679949..681028 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQM50_RS03660 (NCTC8324_00736)	-	681110..681736 (-)	627	WP_002983834.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=1137764 DQM50_RS03640 WP_002983824.1 676449..677486(+) (sepM) [Streptococcus pyogenes strain NCTC8324]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1137764 DQM50_RS03640 WP_002983824.1 676449..677486(+) (sepM) [Streptococcus pyogenes strain NCTC8324]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69