Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | DQM35_RS03635 | Genome accession | NZ_LS483338 |
| Coordinates | 681834..683639 (+) | Length | 601 a.a. |
| NCBI ID | WP_038431433.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain NCTC12064 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 656841..703889 | 681834..683639 | within | 0 |
Gene organization within MGE regions
Location: 656841..703889
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DQM35_RS03510 (NCTC12064_00689) | - | 656893..657672 (+) | 780 | WP_014635570.1 | formate/nitrite transporter family protein | - |
| DQM35_RS09200 | - | 658232..658414 (+) | 183 | WP_011888786.1 | penicillin-binding protein | - |
| DQM35_RS03520 (NCTC12064_00690) | recR | 658461..659057 (+) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| DQM35_RS03525 (NCTC12064_00691) | - | 659158..660204 (+) | 1047 | WP_002994369.1 | D-alanine--D-alanine ligase | - |
| DQM35_RS03530 (NCTC12064_00692) | murF | 660403..661770 (+) | 1368 | WP_002994368.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| DQM35_RS03535 (NCTC12064_00693) | - | 661874..662569 (+) | 696 | WP_002994365.1 | TIGR02206 family membrane protein | - |
| DQM35_RS03545 (NCTC12064_00694) | - | 662817..664361 (+) | 1545 | WP_002989155.1 | peptide chain release factor 3 | - |
| DQM35_RS03550 (NCTC12064_00695) | - | 664668..666287 (+) | 1620 | WP_111679836.1 | DEAD/DEAH box helicase | - |
| DQM35_RS03555 (NCTC12064_00696) | - | 666414..668414 (+) | 2001 | WP_002994363.1 | potassium transporter Kup | - |
| DQM35_RS03560 (NCTC12064_00697) | - | 668438..668716 (-) | 279 | WP_002989164.1 | GIY-YIG nuclease family protein | - |
| DQM35_RS03565 (NCTC12064_00698) | - | 668706..669482 (-) | 777 | WP_002994360.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| DQM35_RS03570 (NCTC12064_00699) | - | 669600..670340 (+) | 741 | WP_012560804.1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase | - |
| DQM35_RS03575 (NCTC12064_00700) | - | 670540..671202 (+) | 663 | WP_002995626.1 | ComEA family DNA-binding protein | - |
| DQM35_RS03580 (NCTC12064_00701) | - | 671183..673426 (+) | 2244 | WP_002995623.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| DQM35_RS03585 (NCTC12064_00702) | holA | 673497..674537 (+) | 1041 | WP_011054659.1 | DNA polymerase III subunit delta | - |
| DQM35_RS03590 (NCTC12064_00703) | sodA | 674634..675239 (+) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| DQM35_RS09205 (NCTC12064_00704) | - | 675406..675639 (+) | 234 | WP_002983979.1 | hypothetical protein | - |
| DQM35_RS09210 (NCTC12064_00705) | - | 675799..676454 (+) | 656 | Protein_631 | serine hydrolase | - |
| DQM35_RS03610 (NCTC12064_00706) | - | 676568..677788 (-) | 1221 | WP_038431438.1 | DUF3114 domain-containing protein | - |
| DQM35_RS03615 (NCTC12064_00707) | queA | 677795..678823 (-) | 1029 | WP_002995782.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| DQM35_RS03620 (NCTC12064_00708) | nagB | 679025..679729 (+) | 705 | WP_002995779.1 | glucosamine-6-phosphate deaminase | - |
| DQM35_RS03625 (NCTC12064_00709) | - | 679848..680564 (+) | 717 | WP_038431436.1 | pseudouridine synthase | - |
| DQM35_RS03630 (NCTC12064_00710) | - | 680859..681821 (+) | 963 | WP_002983995.1 | competence protein CoiA | - |
| DQM35_RS03635 (NCTC12064_00711) | pepF | 681834..683639 (+) | 1806 | WP_038431433.1 | oligoendopeptidase F | Regulator |
| DQM35_RS03640 (NCTC12064_00712) | - | 684015..685211 (+) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| DQM35_RS03645 (NCTC12064_00713) | - | 685277..685984 (+) | 708 | WP_011017939.1 | O-methyltransferase | - |
| DQM35_RS03650 (NCTC12064_00714) | prsA | 686047..687102 (+) | 1056 | WP_011184661.1 | peptidylprolyl isomerase PrsA | - |
| DQM35_RS03655 (NCTC12064_00716) | alaS | 687489..690107 (+) | 2619 | WP_047236119.1 | alanine--tRNA ligase | - |
| DQM35_RS03660 (NCTC12064_00717) | - | 690468..690683 (+) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| DQM35_RS03665 | - | 690680..691440 (+) | 761 | Protein_643 | DUF3169 family protein | - |
| DQM35_RS03670 (NCTC12064_00720) | - | 691459..692154 (+) | 696 | WP_002995750.1 | CPBP family intramembrane glutamic endopeptidase | - |
| DQM35_RS03675 | - | 692246..693403 (-) | 1158 | Protein_645 | IS3 family transposase | - |
| DQM35_RS03680 (NCTC12064_00723) | - | 693499..694725 (-) | 1227 | WP_002993437.1 | chloride channel protein | - |
| DQM35_RS03685 (NCTC12064_00724) | nrdF | 694787..695746 (-) | 960 | WP_002993434.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| DQM35_RS03690 (NCTC12064_00725) | nrdE | 696079..698238 (-) | 2160 | WP_002993430.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| DQM35_RS03695 (NCTC12064_00726) | - | 698258..698476 (-) | 219 | WP_002989242.1 | redoxin NrdH | - |
| DQM35_RS03700 (NCTC12064_00727) | - | 698869..699132 (+) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| DQM35_RS03705 (NCTC12064_00728) | ptsP | 699137..700870 (+) | 1734 | WP_111679837.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| DQM35_RS03710 (NCTC12064_00729) | - | 701055..702482 (+) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| DQM35_RS03715 (NCTC12064_00730) | - | 702577..703851 (+) | 1275 | WP_020837316.1 | polysaccharide deacetylase family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69426.36 Da Isoelectric Point: 4.7090
>NTDB_id=1137307 DQM35_RS03635 WP_038431433.1 681834..683639(+) (pepF) [Streptococcus pyogenes strain NCTC12064]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=1137307 DQM35_RS03635 WP_038431433.1 681834..683639(+) (pepF) [Streptococcus pyogenes strain NCTC12064]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
70.715 |
100 |
0.707 |