Detailed information NTG1137304

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQM35_RS03275
• Genome accession: NZ_LS483338
• Coordinates: 608288..609325 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC12064
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 603288..614325

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM35_RS03250 (NCTC12064_00636)	-	603552..604883 (+)	1332	WP_011054719.1	dipeptidase	-
DQM35_RS03255 (NCTC12064_00637)	arcC	604903..605853 (+)	951	WP_002994815.1	carbamate kinase	-
DQM35_RS03260 (NCTC12064_00638)	asnA	606166..607158 (+)	993	WP_002994813.1	aspartate--ammonia ligase	-
DQM35_RS03265 (NCTC12064_00639)	rsmD	607281..607820 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQM35_RS03270 (NCTC12064_00640)	coaD	607810..608301 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQM35_RS03275 (NCTC12064_00641)	sepM	608288..609325 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQM35_RS03280 (NCTC12064_00642)	-	609739..610716 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQM35_RS03285 (NCTC12064_00644)	-	611164..611784 (+)	621	WP_002992791.1	YutD family protein	-
DQM35_RS03290 (NCTC12064_00645)	rlmN	611788..612867 (+)	1080	WP_038431459.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQM35_RS03295 (NCTC12064_00646)	-	612949..613575 (-)	627	WP_002983834.1	A24 family peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1137304 DQM35_RS03275 WP_010922499.1 608288..609325(+) (sepM) [Streptococcus pyogenes strain NCTC12064]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1137304 DQM35_RS03275 WP_010922499.1 608288..609325(+) (sepM) [Streptococcus pyogenes strain NCTC12064]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693