Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | DQL03_RS05665 | Genome accession | NZ_LS483337 |
| Coordinates | 1112108..1113913 (-) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain NCTC12047 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1091858..1138917 | 1112108..1113913 | within | 0 |
Gene organization within MGE regions
Location: 1091858..1138917
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DQL03_RS05585 (NCTC12047_01109) | - | 1091896..1093170 (-) | 1275 | WP_030127111.1 | polysaccharide deacetylase family protein | - |
| DQL03_RS05590 (NCTC12047_01110) | - | 1093265..1094692 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| DQL03_RS05595 (NCTC12047_01111) | ptsP | 1094877..1096610 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| DQL03_RS05600 (NCTC12047_01112) | - | 1096615..1096878 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| DQL03_RS05605 (NCTC12047_01113) | - | 1097271..1097489 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| DQL03_RS05610 (NCTC12047_01114) | nrdE | 1097509..1099668 (+) | 2160 | WP_002984018.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| DQL03_RS05615 (NCTC12047_01115) | nrdF | 1100001..1100960 (+) | 960 | WP_002987365.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| DQL03_RS05620 (NCTC12047_01116) | - | 1101022..1102248 (+) | 1227 | WP_021775375.1 | chloride channel protein | - |
| DQL03_RS05625 (NCTC12047_01118) | - | 1102344..1103494 (+) | 1151 | WP_111674948.1 | IS3 family transposase | - |
| DQL03_RS05630 (NCTC12047_01119) | - | 1103592..1104287 (-) | 696 | WP_002995750.1 | CPBP family intramembrane glutamic endopeptidase | - |
| DQL03_RS05635 (NCTC12047_01120) | - | 1104306..1105067 (-) | 762 | WP_023080157.1 | DUF3169 family protein | - |
| DQL03_RS05640 (NCTC12047_01121) | - | 1105064..1105279 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| DQL03_RS05645 (NCTC12047_01122) | alaS | 1105640..1108258 (-) | 2619 | WP_047235772.1 | alanine--tRNA ligase | - |
| DQL03_RS05650 (NCTC12047_01124) | prsA | 1108645..1109700 (-) | 1056 | WP_111674949.1 | peptidylprolyl isomerase PrsA | - |
| DQL03_RS05655 (NCTC12047_01125) | - | 1109763..1110470 (-) | 708 | WP_047235770.1 | O-methyltransferase | - |
| DQL03_RS05660 (NCTC12047_01126) | - | 1110536..1111732 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| DQL03_RS05665 (NCTC12047_01127) | pepF | 1112108..1113913 (-) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| DQL03_RS05670 (NCTC12047_01128) | - | 1113926..1114888 (-) | 963 | WP_002983995.1 | competence protein CoiA | - |
| DQL03_RS05675 (NCTC12047_01129) | - | 1115185..1115901 (-) | 717 | WP_002995774.1 | pseudouridine synthase | - |
| DQL03_RS05680 (NCTC12047_01130) | nagB | 1116020..1116724 (-) | 705 | WP_002995779.1 | glucosamine-6-phosphate deaminase | - |
| DQL03_RS05685 (NCTC12047_01131) | queA | 1116926..1117954 (+) | 1029 | WP_111674950.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| DQL03_RS05690 (NCTC12047_01132) | - | 1117961..1119181 (+) | 1221 | WP_111674951.1 | DUF3114 domain-containing protein | - |
| DQL03_RS05695 (NCTC12047_01133) | - | 1119295..1119885 (-) | 591 | WP_002983984.1 | serine hydrolase | - |
| DQL03_RS09400 | - | 1119882..1120109 (-) | 228 | WP_231871582.1 | hypothetical protein | - |
| DQL03_RS05705 (NCTC12047_01134) | - | 1120110..1120343 (-) | 234 | WP_002983979.1 | hypothetical protein | - |
| DQL03_RS05710 (NCTC12047_01135) | sodA | 1120510..1121115 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| DQL03_RS05715 (NCTC12047_01136) | holA | 1121212..1122252 (-) | 1041 | WP_030126963.1 | DNA polymerase III subunit delta | - |
| DQL03_RS05720 (NCTC12047_01137) | - | 1122323..1124566 (-) | 2244 | WP_111674953.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| DQL03_RS05725 (NCTC12047_01138) | - | 1124547..1125209 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| DQL03_RS05730 (NCTC12047_01139) | - | 1125409..1126149 (-) | 741 | WP_012560804.1 | lysophospholipid acyltransferase family protein | - |
| DQL03_RS05735 (NCTC12047_01140) | - | 1126267..1127043 (+) | 777 | WP_002994360.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| DQL03_RS05740 (NCTC12047_01141) | - | 1127033..1127311 (+) | 279 | WP_002989164.1 | GIY-YIG nuclease family protein | - |
| DQL03_RS05745 (NCTC12047_01142) | - | 1127335..1129335 (-) | 2001 | WP_063631977.1 | potassium transporter Kup | - |
| DQL03_RS05750 (NCTC12047_01143) | - | 1129463..1131082 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| DQL03_RS05755 (NCTC12047_01144) | - | 1131389..1132933 (-) | 1545 | WP_111674954.1 | peptide chain release factor 3 | - |
| DQL03_RS05765 (NCTC12047_01145) | - | 1133180..1133875 (-) | 696 | WP_002994365.1 | TIGR02206 family membrane protein | - |
| DQL03_RS05770 (NCTC12047_01146) | - | 1133979..1135346 (-) | 1368 | WP_063631980.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| DQL03_RS05775 (NCTC12047_01147) | - | 1135545..1136591 (-) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| DQL03_RS05780 (NCTC12047_01148) | recR | 1136692..1137288 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| DQL03_RS09545 | - | 1137335..1137526 (-) | 192 | WP_032464443.1 | hypothetical protein | - |
| DQL03_RS05790 (NCTC12047_01149) | - | 1138086..1138865 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=1137257 DQL03_RS05665 WP_011054652.1 1112108..1113913(-) (pepF) [Streptococcus pyogenes strain NCTC12047]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=1137257 DQL03_RS05665 WP_011054652.1 1112108..1113913(-) (pepF) [Streptococcus pyogenes strain NCTC12047]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAATT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAGGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAATT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAGGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |