Detailed information NTG1137204

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL08_RS06355
• Genome accession: NZ_LS483336
• Coordinates: 1232029..1233066 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC12046
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1227029..1238066

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL08_RS06335 (NCTC12046_01268)	-	1227756..1228382 (+)	627	WP_023611777.1	prepilin peptidase	-
DQL08_RS06340 (NCTC12046_01269)	rlmN	1228463..1229542 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL08_RS06345 (NCTC12046_01270)	-	1229546..1230166 (-)	621	WP_002992791.1	YutD family protein	-
DQL08_RS06350 (NCTC12046_01272)	-	1230626..1231603 (-)	978	WP_023611793.1	LacI family DNA-binding transcriptional regulator	-
DQL08_RS06355 (NCTC12046_01273)	sepM	1232029..1233066 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQL08_RS06360 (NCTC12046_01274)	coaD	1233053..1233544 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQL08_RS06365 (NCTC12046_01275)	rsmD	1233534..1234073 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL08_RS06370 (NCTC12046_01276)	asnA	1234196..1235188 (-)	993	WP_023611792.1	aspartate--ammonia ligase	-
DQL08_RS06375 (NCTC12046_01277)	arcC	1235501..1236451 (-)	951	WP_023611802.1	carbamate kinase	-
DQL08_RS06380 (NCTC12046_01278)	-	1236471..1237802 (-)	1332	WP_111687961.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1137204 DQL08_RS06355 WP_010922499.1 1232029..1233066(-) (sepM) [Streptococcus pyogenes strain NCTC12046]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1137204 DQL08_RS06355 WP_010922499.1 1232029..1233066(-) (sepM) [Streptococcus pyogenes strain NCTC12046]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGTATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693