Detailed information NTG1137078

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL28_RS02980
• Genome accession: NZ_LS483334
• Coordinates: 570791..571828 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC12050
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 565791..576828

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL28_RS02955 (NCTC12050_00575)	-	566055..567386 (+)	1332	WP_111676254.1	dipeptidase	-
DQL28_RS02960 (NCTC12050_00576)	arcC	567406..568356 (+)	951	WP_010922501.1	carbamate kinase	-
DQL28_RS02965 (NCTC12050_00577)	asnA	568669..569661 (+)	993	WP_111676256.1	aspartate--ammonia ligase	-
DQL28_RS02970 (NCTC12050_00578)	rsmD	569784..570323 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL28_RS02975 (NCTC12050_00579)	coaD	570313..570804 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQL28_RS02980 (NCTC12050_00580)	sepM	570791..571828 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQL28_RS02985 (NCTC12050_00581)	-	572233..573210 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQL28_RS02990 (NCTC12050_00583)	-	573658..574278 (+)	621	WP_002992791.1	YutD family protein	-
DQL28_RS02995 (NCTC12050_00584)	rlmN	574282..575361 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL28_RS03000 (NCTC12050_00585)	-	575443..576069 (-)	627	WP_023079342.1	prepilin peptidase	-
DQL28_RS03005 (NCTC12050_00586)	-	576297..576824 (+)	528	WP_014635585.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1137078 DQL28_RS02980 WP_010922499.1 570791..571828(+) (sepM) [Streptococcus pyogenes strain NCTC12050]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1137078 DQL28_RS02980 WP_010922499.1 570791..571828(+) (sepM) [Streptococcus pyogenes strain NCTC12050]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693