Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | DQL30_RS03890 | Genome accession | NZ_LS483333 |
| Coordinates | 721369..723174 (+) | Length | 601 a.a. |
| NCBI ID | WP_111713733.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain NCTC12048 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 681588..738371 | 721369..723174 | within | 0 |
Gene organization within MGE regions
Location: 681588..738371
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DQL30_RS03690 (NCTC12048_00727) | - | 681602..682189 (+) | 588 | WP_002989129.1 | YpmS family protein | - |
| DQL30_RS03695 (NCTC12048_00728) | - | 682288..682563 (+) | 276 | WP_111713725.1 | HU family DNA-binding protein | - |
| DQL30_RS03700 (NCTC12048_00729) | - | 682906..684768 (+) | 1863 | WP_011284945.1 | heavy metal translocating P-type ATPase | - |
| DQL30_RS03705 (NCTC12048_00730) | - | 685068..686003 (-) | 936 | WP_021299339.1 | dihydroorotate oxidase | - |
| DQL30_RS03710 (NCTC12048_00731) | - | 686242..686937 (+) | 696 | WP_002983928.1 | phosphoglycerate mutase | - |
| DQL30_RS03715 (NCTC12048_00732) | - | 687044..687565 (+) | 522 | WP_002983930.1 | transcription repressor NadR | - |
| DQL30_RS03720 (NCTC12048_00733) | - | 687726..688268 (+) | 543 | WP_111684770.1 | hypothetical protein | - |
| DQL30_RS03725 (NCTC12048_00734) | - | 688392..689171 (+) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
| DQL30_RS09440 | - | 689731..689922 (+) | 192 | WP_002983936.1 | hypothetical protein | - |
| DQL30_RS03735 (NCTC12048_00735) | recR | 689969..690565 (+) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| DQL30_RS03740 (NCTC12048_00736) | - | 690666..691712 (+) | 1047 | WP_002983941.1 | D-alanine--D-alanine ligase | - |
| DQL30_RS03745 (NCTC12048_00737) | - | 691911..693278 (+) | 1368 | WP_109820917.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| DQL30_RS03750 (NCTC12048_00738) | - | 693382..694077 (+) | 696 | WP_002994365.1 | TIGR02206 family membrane protein | - |
| DQL30_RS03760 (NCTC12048_00739) | - | 694325..695869 (+) | 1545 | WP_002989155.1 | peptide chain release factor 3 | - |
| DQL30_RS03765 (NCTC12048_00740) | - | 696176..697795 (+) | 1620 | WP_011054664.1 | DEAD/DEAH box helicase | - |
| DQL30_RS03770 (NCTC12048_00741) | - | 697922..699922 (+) | 2001 | WP_111684774.1 | potassium transporter Kup | - |
| DQL30_RS03775 (NCTC12048_00742) | - | 699946..700224 (-) | 279 | WP_002989164.1 | GIY-YIG nuclease family protein | - |
| DQL30_RS03780 (NCTC12048_00743) | - | 700214..700990 (-) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| DQL30_RS03785 (NCTC12048_00744) | - | 701108..701848 (+) | 741 | WP_002989170.1 | lysophospholipid acyltransferase family protein | - |
| DQL30_RS03790 (NCTC12048_00745) | - | 702048..702710 (+) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| DQL30_RS03795 (NCTC12048_00746) | - | 702691..704370 (+) | 1680 | Protein_674 | ComEC/Rec2 family competence protein | - |
| DQL30_RS09270 (NCTC12048_00747) | - | 704454..704732 (+) | 279 | WP_227874635.1 | hypothetical protein | - |
| DQL30_RS09275 (NCTC12048_00748) | - | 704719..705039 (+) | 321 | WP_231871051.1 | hypothetical protein | - |
| DQL30_RS03805 (NCTC12048_00749) | - | 705132..705995 (-) | 864 | WP_111713727.1 | IS982 family transposase | - |
| DQL30_RS03815 (NCTC12048_00750) | - | 706492..710136 (+) | 3645 | WP_197708986.1 | adhesin | - |
| DQL30_RS03820 (NCTC12048_00751) | - | 710397..710798 (+) | 402 | WP_111713728.1 | RNA polymerase subunit sigma-70 | - |
| DQL30_RS09510 | - | 710818..710883 (+) | 66 | WP_371399130.1 | hypothetical protein | - |
| DQL30_RS03825 (NCTC12048_00752) | - | 710880..711755 (+) | 876 | WP_269458669.1 | recombinase family protein | - |
| DQL30_RS03830 (NCTC12048_00753) | - | 711929..712354 (+) | 426 | WP_126409737.1 | hypothetical protein | - |
| DQL30_RS03835 (NCTC12048_00754) | - | 712385..712966 (+) | 582 | Protein_683 | ComEC/Rec2 family competence protein | - |
| DQL30_RS03840 (NCTC12048_00755) | holA | 713047..714093 (+) | 1047 | WP_111713730.1 | DNA polymerase III subunit delta | - |
| DQL30_RS03845 (NCTC12048_00756) | sodA | 714183..714788 (+) | 606 | WP_011184668.1 | superoxide dismutase SodA | - |
| DQL30_RS03850 (NCTC12048_00757) | - | 714955..715182 (+) | 228 | WP_030126413.1 | hypothetical protein | - |
| DQL30_RS03860 (NCTC12048_00760) | - | 715137..715989 (+) | 853 | Protein_687 | serine hydrolase | - |
| DQL30_RS03865 (NCTC12048_00761) | - | 716103..717323 (-) | 1221 | WP_111713731.1 | DUF3114 domain-containing protein | - |
| DQL30_RS03870 (NCTC12048_00762) | queA | 717330..718358 (-) | 1029 | WP_023078839.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| DQL30_RS03875 (NCTC12048_00763) | nagB | 718560..719309 (+) | 750 | WP_038434150.1 | glucosamine-6-phosphate deaminase | - |
| DQL30_RS03880 (NCTC12048_00764) | - | 719383..720099 (+) | 717 | WP_011528761.1 | pseudouridine synthase | - |
| DQL30_RS03885 (NCTC12048_00765) | - | 720394..721356 (+) | 963 | WP_111713732.1 | competence protein CoiA | - |
| DQL30_RS03890 (NCTC12048_00766) | pepF | 721369..723174 (+) | 1806 | WP_111713733.1 | oligoendopeptidase F | Regulator |
| DQL30_RS03895 (NCTC12048_00767) | - | 723551..724747 (+) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| DQL30_RS03900 (NCTC12048_00768) | - | 724813..725520 (+) | 708 | WP_032465077.1 | O-methyltransferase | - |
| DQL30_RS03905 (NCTC12048_00769) | prsA | 725583..726638 (+) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| DQL30_RS03910 (NCTC12048_00771) | alaS | 727025..729643 (+) | 2619 | WP_111713734.1 | alanine--tRNA ligase | - |
| DQL30_RS03915 (NCTC12048_00773) | - | 730004..730219 (+) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| DQL30_RS03920 (NCTC12048_00774) | - | 730216..730977 (+) | 762 | WP_002995753.1 | DUF3169 family protein | - |
| DQL30_RS03925 (NCTC12048_00775) | - | 730996..731691 (+) | 696 | WP_002995750.1 | CPBP family intramembrane glutamic endopeptidase | - |
| DQL30_RS03930 | - | 731788..732938 (-) | 1151 | Protein_701 | IS3 family transposase | - |
| DQL30_RS03935 (NCTC12048_00779) | - | 733077..734303 (-) | 1227 | WP_409212603.1 | chloride channel protein | - |
| DQL30_RS03940 (NCTC12048_00780) | nrdF | 734365..735324 (-) | 960 | WP_011017933.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| DQL30_RS03945 (NCTC12048_00782) | nrdE | 735657..737816 (-) | 2160 | WP_111713736.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| DQL30_RS03950 (NCTC12048_00783) | - | 737836..738054 (-) | 219 | WP_002989242.1 | redoxin NrdH | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69320.42 Da Isoelectric Point: 4.9542
>NTDB_id=1137029 DQL30_RS03890 WP_111713733.1 721369..723174(+) (pepF) [Streptococcus pyogenes strain NCTC12048]
MTNNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQGYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGNYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTNNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQGYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGNYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=1137029 DQL30_RS03890 WP_111713733.1 721369..723174(+) (pepF) [Streptococcus pyogenes strain NCTC12048]
ATGACTAATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGGATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGACCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTAGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGTTCTGGAGCTTATTCGGGTGGTTCCTATGATACCAATGCCTTTATGCTATTAAACT
GGCAAGATACCTTAGACAATCTATACACTTTAGTTCATGAAACTGGGCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGAAATTACAGTATTTTCTTGGCAGAAATTGCATCCACAACGAATGAAAATATTATGACAGAAGC
TCTCTTAAATGAGGTTCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGACGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTAATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGGATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGACCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTAGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGTTCTGGAGCTTATTCGGGTGGTTCCTATGATACCAATGCCTTTATGCTATTAAACT
GGCAAGATACCTTAGACAATCTATACACTTTAGTTCATGAAACTGGGCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGAAATTACAGTATTTTCTTGGCAGAAATTGCATCCACAACGAATGAAAATATTATGACAGAAGC
TCTCTTAAATGAGGTTCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGACGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
70.216 |
100 |
0.702 |