Detailed information NTG1136978

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQM36_RS06060
• Genome accession: NZ_LS483332
• Coordinates: 1175263..1176300 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain NCTC12696
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1170263..1181300

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM36_RS06040 (NCTC12696_01192)	-	1171004..1171630 (+)	627	WP_002983834.1	prepilin peptidase	-
DQM36_RS06045 (NCTC12696_01193)	rlmN	1171712..1172791 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQM36_RS06050 (NCTC12696_01194)	-	1172795..1173415 (-)	621	WP_002992791.1	YutD family protein	-
DQM36_RS06055 (NCTC12696_01195)	-	1173863..1174840 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQM36_RS06060 (NCTC12696_01196)	sepM	1175263..1176300 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
DQM36_RS06065 (NCTC12696_01197)	coaD	1176287..1176778 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQM36_RS06070 (NCTC12696_01198)	rsmD	1176768..1177307 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQM36_RS06075 (NCTC12696_01199)	asnA	1177430..1178422 (-)	993	WP_002994813.1	aspartate--ammonia ligase	-
DQM36_RS06080 (NCTC12696_01200)	arcC	1178735..1179685 (-)	951	WP_002994815.1	carbamate kinase	-
DQM36_RS06085 (NCTC12696_01201)	-	1179705..1181036 (-)	1332	WP_011054719.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=1136978 DQM36_RS06060 WP_002983824.1 1175263..1176300(-) (sepM) [Streptococcus pyogenes strain NCTC12696]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1136978 DQM36_RS06060 WP_002983824.1 1175263..1176300(-) (sepM) [Streptococcus pyogenes strain NCTC12696]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAACGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69