Detailed information NTG1136922

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL10_RS06425
• Genome accession: NZ_LS483331
• Coordinates: 1265107..1266144 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC12057
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1260107..1271144

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL10_RS06405 (NCTC12057_01275)	-	1260857..1261483 (+)	627	WP_010922497.1	prepilin peptidase	-
DQL10_RS06410 (NCTC12057_01276)	rlmN	1261565..1262644 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL10_RS06415 (NCTC12057_01277)	-	1262648..1263268 (-)	621	WP_002992791.1	YutD family protein	-
DQL10_RS06420 (NCTC12057_01279)	-	1263716..1264693 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQL10_RS06425 (NCTC12057_01280)	sepM	1265107..1266144 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQL10_RS06430 (NCTC12057_01281)	coaD	1266131..1266622 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQL10_RS06435 (NCTC12057_01282)	rsmD	1266612..1267151 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL10_RS06440 (NCTC12057_01283)	asnA	1267274..1268266 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQL10_RS06445 (NCTC12057_01284)	arcC	1268579..1269529 (-)	951	WP_015057899.1	carbamate kinase	-
DQL10_RS06450 (NCTC12057_01285)	-	1269549..1270880 (-)	1332	WP_023612508.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1136922 DQL10_RS06425 WP_010922499.1 1265107..1266144(-) (sepM) [Streptococcus pyogenes strain NCTC12057]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1136922 DQL10_RS06425 WP_010922499.1 1265107..1266144(-) (sepM) [Streptococcus pyogenes strain NCTC12057]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693