Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | DQL25_RS04150 | Genome accession | NZ_LS483330 |
| Coordinates | 769385..771190 (+) | Length | 601 a.a. |
| NCBI ID | WP_111703227.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain NCTC8328 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 744414..791481 | 769385..771190 | within | 0 |
Gene organization within MGE regions
Location: 744414..791481
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DQL25_RS04025 (NCTC8328_00802) | - | 744466..745245 (+) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
| DQL25_RS09925 | - | 745805..745987 (+) | 183 | WP_011888786.1 | penicillin-binding protein | - |
| DQL25_RS04035 (NCTC8328_00803) | recR | 746034..746630 (+) | 597 | WP_111703216.1 | recombination mediator RecR | - |
| DQL25_RS04040 (NCTC8328_00804) | - | 746731..747777 (+) | 1047 | WP_111703217.1 | D-alanine--D-alanine ligase | - |
| DQL25_RS04045 (NCTC8328_00805) | - | 747968..749359 (+) | 1392 | WP_111677348.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| DQL25_RS04050 (NCTC8328_00806) | - | 749439..750134 (+) | 696 | WP_002983946.1 | TIGR02206 family membrane protein | - |
| DQL25_RS04060 (NCTC8328_00807) | - | 750382..751926 (+) | 1545 | WP_111703218.1 | peptide chain release factor 3 | - |
| DQL25_RS04065 (NCTC8328_00808) | - | 752233..753852 (+) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| DQL25_RS04070 (NCTC8328_00809) | - | 753979..755979 (+) | 2001 | WP_111703219.1 | potassium transporter Kup | - |
| DQL25_RS04075 (NCTC8328_00810) | - | 756003..756281 (-) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| DQL25_RS04080 (NCTC8328_00811) | - | 756271..757047 (-) | 777 | WP_002994360.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| DQL25_RS04085 (NCTC8328_00812) | - | 757165..757905 (+) | 741 | WP_168389440.1 | lysophospholipid acyltransferase family protein | - |
| DQL25_RS04090 (NCTC8328_00813) | - | 758105..758767 (+) | 663 | WP_111703221.1 | ComEA family DNA-binding protein | - |
| DQL25_RS04095 (NCTC8328_00814) | - | 758748..760991 (+) | 2244 | WP_111703222.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| DQL25_RS04100 (NCTC8328_00815) | holA | 761062..762102 (+) | 1041 | WP_011888795.1 | DNA polymerase III subunit delta | - |
| DQL25_RS04105 (NCTC8328_00816) | sodA | 762199..762804 (+) | 606 | WP_023612500.1 | superoxide dismutase SodA | - |
| DQL25_RS04110 (NCTC8328_00817) | - | 762971..763198 (+) | 228 | WP_011054657.1 | hypothetical protein | - |
| DQL25_RS04120 (NCTC8328_00820) | - | 763183..764005 (+) | 823 | Protein_753 | serine hydrolase | - |
| DQL25_RS04125 (NCTC8328_00821) | - | 764119..765339 (-) | 1221 | WP_111703223.1 | DUF3114 domain-containing protein | - |
| DQL25_RS04130 (NCTC8328_00822) | queA | 765344..766372 (-) | 1029 | WP_111703224.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| DQL25_RS04135 (NCTC8328_00823) | nagB | 766574..767278 (+) | 705 | WP_111703225.1 | glucosamine-6-phosphate deaminase | - |
| DQL25_RS04140 (NCTC8328_00824) | - | 767397..768113 (+) | 717 | WP_002989197.1 | pseudouridine synthase | - |
| DQL25_RS04145 (NCTC8328_00825) | - | 768410..769372 (+) | 963 | WP_111703226.1 | competence protein CoiA | - |
| DQL25_RS04150 (NCTC8328_00826) | pepF | 769385..771190 (+) | 1806 | WP_111703227.1 | oligoendopeptidase F | Regulator |
| DQL25_RS04155 (NCTC8328_00827) | - | 771566..772762 (+) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| DQL25_RS04160 (NCTC8328_00828) | - | 772828..773535 (+) | 708 | WP_002989211.1 | O-methyltransferase | - |
| DQL25_RS04165 (NCTC8328_00829) | prsA | 773598..774653 (+) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| DQL25_RS04170 (NCTC8328_00831) | alaS | 775040..777658 (+) | 2619 | WP_031488551.1 | alanine--tRNA ligase | - |
| DQL25_RS04175 (NCTC8328_00833) | - | 778018..778233 (+) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| DQL25_RS04180 (NCTC8328_00834) | - | 778230..778991 (+) | 762 | WP_111703228.1 | DUF3169 family protein | - |
| DQL25_RS04185 (NCTC8328_00835) | - | 779010..779705 (+) | 696 | WP_111703229.1 | CPBP family intramembrane glutamic endopeptidase | - |
| DQL25_RS04195 (NCTC8328_00838) | - | 781091..782317 (-) | 1227 | WP_409231131.1 | chloride channel protein | - |
| DQL25_RS04200 (NCTC8328_00839) | nrdF | 782379..783338 (-) | 960 | WP_011017933.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| DQL25_RS04205 (NCTC8328_00841) | nrdE | 783671..785830 (-) | 2160 | WP_111703231.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| DQL25_RS04210 (NCTC8328_00842) | - | 785850..786068 (-) | 219 | WP_002989242.1 | redoxin NrdH | - |
| DQL25_RS04215 (NCTC8328_00843) | - | 786461..786724 (+) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| DQL25_RS04220 (NCTC8328_00844) | ptsP | 786729..788462 (+) | 1734 | WP_111703232.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| DQL25_RS04225 (NCTC8328_00845) | - | 788647..790074 (+) | 1428 | WP_111703233.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| DQL25_RS04230 (NCTC8328_00846) | - | 790169..791443 (+) | 1275 | WP_012560787.1 | polysaccharide deacetylase family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69368.22 Da Isoelectric Point: 4.7370
>NTDB_id=1136859 DQL25_RS04150 WP_111703227.1 769385..771190(+) (pepF) [Streptococcus pyogenes strain NCTC8328]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENVELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=1136859 DQL25_RS04150 WP_111703227.1 769385..771190(+) (pepF) [Streptococcus pyogenes strain NCTC8328]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGATGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAATATTATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGACACTTTATTAGAAACGGTTAACAAACATTTACCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGATGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCAGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAATATTATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.048 |
100 |
0.71 |