Detailed information NTG1136697

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL07_RS06125
• Genome accession: NZ_LS483327
• Coordinates: 1181541..1182578 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC12069
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1176541..1187578

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL07_RS06105 (NCTC12069_01207)	-	1177290..1177916 (+)	627	WP_002983834.1	prepilin peptidase	-
DQL07_RS06110 (NCTC12069_01208)	rlmN	1177998..1179077 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL07_RS06115 (NCTC12069_01209)	-	1179081..1179701 (-)	621	WP_231871297.1	YutD family protein	-
DQL07_RS06120 (NCTC12069_01211)	-	1180149..1181126 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQL07_RS06125 (NCTC12069_01212)	sepM	1181541..1182578 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQL07_RS06130 (NCTC12069_01213)	coaD	1182565..1183056 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQL07_RS06135 (NCTC12069_01214)	rsmD	1183046..1183585 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL07_RS06140 (NCTC12069_01215)	asnA	1183708..1184700 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQL07_RS06145 (NCTC12069_01216)	arcC	1185013..1185963 (-)	951	WP_010922501.1	carbamate kinase	-
DQL07_RS06150 (NCTC12069_01217)	-	1185983..1187314 (-)	1332	WP_011285641.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1136697 DQL07_RS06125 WP_010922499.1 1181541..1182578(-) (sepM) [Streptococcus pyogenes strain NCTC12069]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1136697 DQL07_RS06125 WP_010922499.1 1181541..1182578(-) (sepM) [Streptococcus pyogenes strain NCTC12069]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693