Detailed information NTG1136626

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL59_RS05065
• Genome accession: NZ_LS483326
• Coordinates: 983070..984107 (-)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain NCTC12045
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 978070..989107

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL59_RS05045 (NCTC12045_01005)	-	978811..979437 (+)	627	WP_002989076.1	prepilin peptidase	-
DQL59_RS05050 (NCTC12045_01006)	rlmN	979519..980598 (-)	1080	WP_111681196.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL59_RS05055 (NCTC12045_01007)	-	980602..981222 (-)	621	WP_227874801.1	YutD family protein	-
DQL59_RS05060 (NCTC12045_01009)	-	981670..982647 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQL59_RS05065 (NCTC12045_01010)	sepM	983070..984107 (-)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
DQL59_RS05070 (NCTC12045_01011)	coaD	984094..984585 (-)	492	WP_111681198.1	pantetheine-phosphate adenylyltransferase	-
DQL59_RS05075 (NCTC12045_01012)	rsmD	984575..985114 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL59_RS05080 (NCTC12045_01013)	asnA	985237..986229 (-)	993	WP_111681199.1	aspartate--ammonia ligase	-
DQL59_RS05085 (NCTC12045_01014)	arcC	986542..987492 (-)	951	WP_009880962.1	carbamate kinase	-
DQL59_RS05090 (NCTC12045_01015)	-	987512..988843 (-)	1332	WP_111681200.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=1136626 DQL59_RS05065 WP_002983824.1 983070..984107(-) (sepM) [Streptococcus pyogenes strain NCTC12045]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1136626 DQL59_RS05065 WP_002983824.1 983070..984107(-) (sepM) [Streptococcus pyogenes strain NCTC12045]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAACGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69