Detailed information    

insolico Bioinformatically predicted

Overview

Name   pepF   Type   Regulator
Locus tag   DQL59_RS04385 Genome accession   NZ_LS483326
Coordinates   862516..864321 (-) Length   601 a.a.
NCBI ID   WP_030127119.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC12045     
Function   degradation of XIP; competence shut-off (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 842224..889279 862516..864321 within 0


Gene organization within MGE regions


Location: 842224..889279
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL59_RS04300 (NCTC12045_00852) - 842262..843536 (-) 1275 WP_002989251.1 polysaccharide deacetylase family protein -
  DQL59_RS04305 (NCTC12045_00853) - 843631..845058 (-) 1428 WP_111681156.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase -
  DQL59_RS04310 (NCTC12045_00854) ptsP 845243..846976 (-) 1734 WP_002984033.1 phosphoenolpyruvate--protein phosphotransferase -
  DQL59_RS04315 (NCTC12045_00855) - 846981..847244 (-) 264 WP_002984031.1 phosphocarrier protein HPr -
  DQL59_RS04320 (NCTC12045_00856) - 847637..847855 (+) 219 WP_002989242.1 redoxin NrdH -
  DQL59_RS04325 (NCTC12045_00857) nrdE 847875..850034 (+) 2160 WP_111681157.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
  DQL59_RS04330 (NCTC12045_00858) nrdF 850367..851326 (+) 960 WP_002987365.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
  DQL59_RS04335 (NCTC12045_00859) - 851388..852614 (+) 1227 WP_227874810.1 chloride channel protein -
  DQL59_RS04345 - 852752..853902 (+) 1151 Protein_804 IS3 family transposase -
  DQL59_RS04350 (NCTC12045_00862) - 854000..854695 (-) 696 WP_111677333.1 CPBP family intramembrane glutamic endopeptidase -
  DQL59_RS04355 (NCTC12045_00863) - 854714..855475 (-) 762 WP_011888802.1 DUF3169 family protein -
  DQL59_RS04360 (NCTC12045_00864) - 855472..855687 (-) 216 WP_002989220.1 helix-turn-helix transcriptional regulator -
  DQL59_RS04365 (NCTC12045_00866) alaS 856048..858666 (-) 2619 WP_111681159.1 alanine--tRNA ligase -
  DQL59_RS04370 (NCTC12045_00868) prsA 859053..860108 (-) 1056 WP_111681160.1 peptidylprolyl isomerase PrsA -
  DQL59_RS04375 (NCTC12045_00869) - 860171..860878 (-) 708 WP_047235770.1 O-methyltransferase -
  DQL59_RS04380 (NCTC12045_00870) - 860944..862140 (-) 1197 WP_111681161.1 OFA family MFS transporter -
  DQL59_RS04385 (NCTC12045_00871) pepF 862516..864321 (-) 1806 WP_030127119.1 oligoendopeptidase F Regulator
  DQL59_RS04390 (NCTC12045_00872) - 864334..865296 (-) 963 WP_002995771.1 competence protein CoiA -
  DQL59_RS04395 (NCTC12045_00873) - 865593..866309 (-) 717 WP_002995774.1 pseudouridine synthase -
  DQL59_RS04400 (NCTC12045_00874) nagB 866428..867132 (-) 705 WP_002995779.1 glucosamine-6-phosphate deaminase -
  DQL59_RS04405 (NCTC12045_00875) queA 867334..868362 (+) 1029 WP_111681162.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
  DQL59_RS04410 (NCTC12045_00876) - 868369..869589 (+) 1221 WP_111681163.1 DUF3114 domain-containing protein -
  DQL59_RS04415 (NCTC12045_00877) - 869660..870250 (-) 591 WP_002983984.1 serine hydrolase -
  DQL59_RS04420 (NCTC12045_00878) - 870247..870495 (-) 249 WP_111681164.1 serine hydrolase -
  DQL59_RS04425 (NCTC12045_00879) - 870480..870707 (-) 228 WP_111681165.1 hypothetical protein -
  DQL59_RS04430 (NCTC12045_00880) sodA 870874..871479 (-) 606 WP_111681166.1 superoxide dismutase SodA -
  DQL59_RS04435 (NCTC12045_00881) holA 871576..872616 (-) 1041 WP_030126963.1 DNA polymerase III subunit delta -
  DQL59_RS04440 (NCTC12045_00882) - 872687..874930 (-) 2244 WP_111681167.1 DNA internalization-related competence protein ComEC/Rec2 -
  DQL59_RS04445 (NCTC12045_00883) - 874911..875573 (-) 663 WP_111681168.1 ComEA family DNA-binding protein -
  DQL59_RS04450 (NCTC12045_00884) - 875773..876513 (-) 741 WP_012560804.1 lysophospholipid acyltransferase family protein -
  DQL59_RS04455 (NCTC12045_00885) - 876631..877407 (+) 777 WP_011888792.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  DQL59_RS04460 (NCTC12045_00886) - 877397..877675 (+) 279 WP_011017953.1 GIY-YIG nuclease family protein -
  DQL59_RS04465 (NCTC12045_00887) - 877698..879698 (-) 2001 WP_111681169.1 potassium transporter Kup -
  DQL59_RS04470 (NCTC12045_00888) - 879825..881444 (-) 1620 WP_002989158.1 DEAD/DEAH box helicase -
  DQL59_RS04475 (NCTC12045_00889) - 881751..883295 (-) 1545 WP_002989155.1 peptide chain release factor 3 -
  DQL59_RS04485 (NCTC12045_00890) - 883543..884238 (-) 696 WP_031488543.1 TIGR02206 family membrane protein -
  DQL59_RS04490 (NCTC12045_00891) - 884342..885709 (-) 1368 WP_109820917.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  DQL59_RS04495 (NCTC12045_00892) - 885908..886954 (-) 1047 WP_111681170.1 D-alanine--D-alanine ligase -
  DQL59_RS04500 (NCTC12045_00893) recR 887055..887651 (-) 597 WP_002983939.1 recombination mediator RecR -
  DQL59_RS09150 - 887698..887889 (-) 192 WP_002983936.1 hypothetical protein -
  DQL59_RS04510 (NCTC12045_00894) - 888448..889227 (-) 780 WP_014407680.1 formate/nitrite transporter family protein -

Sequence

Protein


Download         Length: 601 a.a.        Molecular weight: 69408.48 Da        Isoelectric Point: 4.8408

>NTDB_id=1136622 DQL59_RS04385 WP_030127119.1 862516..864321(-) (pepF) [Streptococcus pyogenes strain NCTC12045]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEVEASKGFAGHLLDSSANLLKVTKTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMMLHQEDYQAFLTETPELKVYNHFFDKLFQAREHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPIVRNDKGENIELTHGNFISLMESKDRSVRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS

Nucleotide


Download         Length: 1806 bp        

>NTDB_id=1136622 DQL59_RS04385 WP_030127119.1 862516..864321(-) (pepF) [Streptococcus pyogenes strain NCTC12045]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAGTTGAGGCATCTAAAGGTTTTGCTGGTCATTTGCTGGATTCTAGTGCTAATT
TGTTAAAGGTTACAAAAACATATTTAGAATTGGCTCGTCGTGTGGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTCTTTTC
ATTCTATGATCCAGAAGTGATGATGCTTCATCAAGAAGACTATCAGGCTTTCCTTACTGAAACCCCTGAGTTGAAAGTGT
ACAACCATTTCTTTGACAAATTATTCCAAGCCCGCGAACATGTTCTTAGTCAAGCAGAAGAGGAATTATTAGCAGGAGCT
CAAGAAATTTTCAATGGTGCGGAAGAAACCTTTAGTATTCTTGATAACGCTGACATTGTTTTCCCGATAGTCAGAAATGA
TAAAGGTGAAAACATTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCGTTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATCTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAAGATTACGCAGATCGTGTGCATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCATGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAATT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAGGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGTTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCCGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA

Domains

Predicted by InterproScan.

Oligopeptidase F (Peptidase_M3_N)

(112-181)

Peptidase family M3 (Peptidase_M3)

(202-581)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pepF Streptococcus salivarius strain HSISS4

70.549

100

0.705

Multiple sequence alignment