Detailed information NTG1136475

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL15_RS03080
• Genome accession: NZ_LS483323
• Coordinates: 590465..591502 (+)
• Length: 345 a.a.
• NCBI ID: WP_002989068.1
• Uniprot ID: Q1JKX2
• Organism: Streptococcus pyogenes strain NCTC8300
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 585465..596502

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL15_RS03055 (NCTC8300_00601)	-	585728..587059 (+)	1332	WP_002989063.1	dipeptidase	-
DQL15_RS03060 (NCTC8300_00602)	arcC	587079..588029 (+)	951	WP_002989065.1	carbamate kinase	-
DQL15_RS03065 (NCTC8300_00603)	asnA	588343..589335 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQL15_RS03070 (NCTC8300_00604)	rsmD	589458..589997 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL15_RS03075 (NCTC8300_00605)	coaD	589987..590478 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQL15_RS03080 (NCTC8300_00606)	sepM	590465..591502 (+)	1038	WP_002989068.1	SepM family pheromone-processing serine protease	Regulator
DQL15_RS03085 (NCTC8300_00607)	-	591907..592884 (+)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
DQL15_RS03090 (NCTC8300_00608)	-	593332..593952 (+)	621	WP_032461520.1	YutD family protein	-
DQL15_RS03095 (NCTC8300_00609)	rlmN	593956..595035 (+)	1080	WP_002989074.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL15_RS03100 (NCTC8300_00610)	-	595117..595743 (-)	627	WP_002989076.1	prepilin peptidase	-
DQL15_RS03105 (NCTC8300_00611)	-	595971..596498 (+)	528	WP_002983837.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37527.17 Da
• Isoelectric Point: 9.5788

>NTDB_id=1136475 DQL15_RS03080 WP_002989068.1 590465..591502(+) (sepM) [Streptococcus pyogenes strain NCTC8300]
MKRLNKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1136475 DQL15_RS03080 WP_002989068.1 590465..591502(+) (sepM) [Streptococcus pyogenes strain NCTC8300]
ATGAAAAGACTTAACAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: Q1JKX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69