Detailed information NTG1136420

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL05_RS02960
• Genome accession: NZ_LS483322
• Coordinates: 567486..568523 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC12066
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 562486..573523

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL05_RS02935 (NCTC12066_00576)	-	562750..564081 (+)	1332	WP_011285641.1	dipeptidase	-
DQL05_RS02940 (NCTC12066_00577)	arcC	564101..565051 (+)	951	WP_010922501.1	carbamate kinase	-
DQL05_RS02945 (NCTC12066_00578)	asnA	565364..566356 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQL05_RS02950 (NCTC12066_00579)	rsmD	566479..567018 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL05_RS02955 (NCTC12066_00580)	coaD	567008..567499 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQL05_RS02960 (NCTC12066_00581)	sepM	567486..568523 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQL05_RS02965 (NCTC12066_00582)	-	568939..569916 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQL05_RS02970 (NCTC12066_00584)	-	570364..570984 (+)	621	WP_023610891.1	YutD family protein	-
DQL05_RS02975 (NCTC12066_00585)	rlmN	570988..572067 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL05_RS02980 (NCTC12066_00586)	-	572149..572775 (-)	627	WP_002989076.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1136420 DQL05_RS02960 WP_010922499.1 567486..568523(+) (sepM) [Streptococcus pyogenes strain NCTC12066]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1136420 DQL05_RS02960 WP_010922499.1 567486..568523(+) (sepM) [Streptococcus pyogenes strain NCTC12066]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693