Detailed information NTG1136361

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL06_RS03305
• Genome accession: NZ_LS483321
• Coordinates: 627655..628692 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC8314
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 622655..633692

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL06_RS03280 (NCTC8314_00652)	-	622919..624250 (+)	1332	WP_009880963.1	dipeptidase	-
DQL06_RS03285 (NCTC8314_00653)	arcC	624270..625220 (+)	951	WP_063631992.1	carbamate kinase	-
DQL06_RS03290 (NCTC8314_00654)	asnA	625533..626525 (+)	993	WP_010922500.1	aspartate--ammonia ligase	-
DQL06_RS03295 (NCTC8314_00655)	rsmD	626648..627187 (+)	540	WP_111689510.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL06_RS03300 (NCTC8314_00656)	coaD	627177..627668 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQL06_RS03305 (NCTC8314_00657)	sepM	627655..628692 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQL06_RS03310 (NCTC8314_00658)	-	629106..630083 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQL06_RS03315 (NCTC8314_00660)	-	630531..631151 (+)	621	WP_002992791.1	YutD family protein	-
DQL06_RS03320 (NCTC8314_00661)	rlmN	631155..632234 (+)	1080	WP_030126386.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL06_RS03325 (NCTC8314_00662)	-	632316..632942 (-)	627	WP_030126387.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1136361 DQL06_RS03305 WP_010922499.1 627655..628692(+) (sepM) [Streptococcus pyogenes strain NCTC8314]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1136361 DQL06_RS03305 WP_010922499.1 627655..628692(+) (sepM) [Streptococcus pyogenes strain NCTC8314]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693