Detailed information NTG1136271

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DQL82_RS10905
• Genome accession: NZ_LS483319
• Coordinates: 2078044..2079087 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NCTC13140
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2073044..2084087

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL82_RS10875 (NCTC13140_02033)	-	2073462..2074718 (-)	1257	WP_001795438.1	aminopeptidase	-
DQL82_RS10880 (NCTC13140_02034)	-	2074721..2074921 (-)	201	WP_000180461.1	DUF1128 family protein	-
DQL82_RS10885 (NCTC13140_02035)	-	2075068..2075532 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DQL82_RS10890 (NCTC13140_02036)	-	2075539..2075814 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DQL82_RS10895 (NCTC13140_02037)	-	2076092..2077309 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
DQL82_RS10900 (NCTC13140_02038)	vraR	2077425..2078054 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
DQL82_RS10905 (NCTC13140_02039)	vraS	2078044..2079087 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DQL82_RS10910 (NCTC13140_02040)	liaF	2079084..2079785 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DQL82_RS10915 (NCTC13140_02041)	-	2079800..2080186 (-)	387	WP_001110179.1	hypothetical protein	-
DQL82_RS10920 (NCTC13140_02042)	map	2080403..2081161 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
DQL82_RS10930 (NCTC13140_02043)	-	2081747..2082733 (+)	987	WP_000999713.1	FUSC family protein	-
DQL82_RS10940 (NCTC13140_02044)	-	2083164..2083577 (-)	414	WP_001549145.1	hypothetical protein	-
DQL82_RS10945	-	2083606..2083716 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1136271 DQL82_RS10905 WP_001017131.1 2078044..2079087(-) (vraS) [Staphylococcus aureus strain NCTC13140]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1136271 DQL82_RS10905 WP_001017131.1 2078044..2079087(-) (vraS) [Staphylococcus aureus strain NCTC13140]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1