Detailed information NTG1136169

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DQL75_RS10250
• Genome accession: NZ_LS483317
• Coordinates: 2005142..2006185 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NCTC5663
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2000142..2011185

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL75_RS10220 (NCTC5663_01936)	-	2000563..2001819 (-)	1257	WP_078064589.1	aminopeptidase	-
DQL75_RS10225 (NCTC5663_01937)	-	2001822..2002022 (-)	201	WP_000180460.1	DUF1128 family protein	-
DQL75_RS10230 (NCTC5663_01938)	-	2002169..2002633 (+)	465	WP_001571474.1	low molecular weight protein-tyrosine-phosphatase	-
DQL75_RS10235 (NCTC5663_01939)	-	2002640..2002915 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DQL75_RS10240 (NCTC5663_01940)	-	2003193..2004410 (+)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
DQL75_RS10245 (NCTC5663_01941)	vraR	2004523..2005152 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
DQL75_RS10250 (NCTC5663_01942)	vraS	2005142..2006185 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DQL75_RS10255 (NCTC5663_01943)	liaF	2006182..2006883 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DQL75_RS10260 (NCTC5663_01944)	-	2006898..2007284 (-)	387	WP_001110179.1	hypothetical protein	-
DQL75_RS10265 (NCTC5663_01945)	map	2007500..2008258 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
DQL75_RS10270 (NCTC5663_01946)	-	2008728..2009714 (+)	987	WP_111762469.1	FUSC family protein	-
DQL75_RS10275 (NCTC5663_01947)	-	2010202..2010615 (-)	414	WP_111762822.1	hypothetical protein	-
DQL75_RS10280	-	2010644..2010754 (-)	111	WP_111762470.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1136169 DQL75_RS10250 WP_001017131.1 2005142..2006185(-) (vraS) [Staphylococcus aureus strain NCTC5663]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1136169 DQL75_RS10250 WP_001017131.1 2005142..2006185(-) (vraS) [Staphylococcus aureus strain NCTC5663]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTGGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1