Detailed information NTG1136126

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DQL73_RS10380
• Genome accession: NZ_LS483316
• Coordinates: 2009174..2010217 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NCTC13395
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2004174..2015217

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL73_RS10350 (NCTC13395_01947)	-	2004592..2005848 (-)	1257	WP_001795438.1	aminopeptidase	-
DQL73_RS10355 (NCTC13395_01948)	-	2005851..2006051 (-)	201	WP_000180461.1	DUF1128 family protein	-
DQL73_RS10360 (NCTC13395_01949)	-	2006198..2006662 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DQL73_RS10365 (NCTC13395_01950)	-	2006669..2006944 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DQL73_RS10370 (NCTC13395_01951)	-	2007222..2008439 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
DQL73_RS10375 (NCTC13395_01952)	vraR	2008555..2009184 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
DQL73_RS10380 (NCTC13395_01953)	vraS	2009174..2010217 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DQL73_RS10385 (NCTC13395_01954)	liaF	2010214..2010915 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DQL73_RS10390 (NCTC13395_01955)	-	2010930..2011316 (-)	387	WP_001110179.1	hypothetical protein	-
DQL73_RS10395 (NCTC13395_01956)	map	2011533..2012291 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
DQL73_RS10405 (NCTC13395_01957)	-	2012878..2013864 (+)	987	WP_000999713.1	FUSC family protein	-
DQL73_RS10415 (NCTC13395_01958)	-	2014295..2014708 (-)	414	WP_078168791.1	hypothetical protein	-
DQL73_RS10420	-	2014737..2014847 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1136126 DQL73_RS10380 WP_001017131.1 2009174..2010217(-) (vraS) [Staphylococcus aureus strain NCTC13395]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1136126 DQL73_RS10380 WP_001017131.1 2009174..2010217(-) (vraS) [Staphylococcus aureus strain NCTC13395]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1