Detailed information NTG1136062

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL11_RS03060
• Genome accession: NZ_LS483315
• Coordinates: 587695..588732 (+)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain NCTC12059
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 582695..593732

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL11_RS03035 (NCTC12059_00595)	-	582959..584290 (+)	1332	WP_111704575.1	dipeptidase	-
DQL11_RS03040 (NCTC12059_00596)	arcC	584310..585260 (+)	951	WP_010922501.1	carbamate kinase	-
DQL11_RS03045 (NCTC12059_00597)	asnA	585573..586565 (+)	993	WP_012560825.1	aspartate--ammonia ligase	-
DQL11_RS03050 (NCTC12059_00598)	rsmD	586688..587227 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL11_RS03055 (NCTC12059_00599)	coaD	587217..587708 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQL11_RS03060 (NCTC12059_00600)	sepM	587695..588732 (+)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
DQL11_RS03065 (NCTC12059_00601)	-	589146..590123 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQL11_RS03070 (NCTC12059_00603)	-	590571..591191 (+)	621	WP_002992791.1	YutD family protein	-
DQL11_RS03075 (NCTC12059_00604)	rlmN	591195..592274 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL11_RS03080 (NCTC12059_00605)	-	592356..592982 (-)	627	WP_111704576.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=1136062 DQL11_RS03060 WP_002983824.1 587695..588732(+) (sepM) [Streptococcus pyogenes strain NCTC12059]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1136062 DQL11_RS03060 WP_002983824.1 587695..588732(+) (sepM) [Streptococcus pyogenes strain NCTC12059]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69