Detailed information NTG1136030

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DQL90_RS10110
• Genome accession: NZ_LS483314
• Coordinates: 1968456..1969499 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NCTC3761
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1963456..1974499

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL90_RS10080 (NCTC3761_01913)	-	1963878..1965134 (-)	1257	WP_001793428.1	aminopeptidase	-
DQL90_RS10085 (NCTC3761_01914)	-	1965137..1965337 (-)	201	WP_000180463.1	DUF1128 family protein	-
DQL90_RS10090 (NCTC3761_01915)	-	1965484..1965948 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DQL90_RS10095 (NCTC3761_01916)	-	1965955..1966230 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DQL90_RS10100 (NCTC3761_01917)	-	1966508..1967725 (+)	1218	WP_042727579.1	YihY/virulence factor BrkB family protein	-
DQL90_RS10105 (NCTC3761_01918)	vraR	1967837..1968466 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
DQL90_RS10110 (NCTC3761_01919)	vraS	1968456..1969499 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DQL90_RS10115 (NCTC3761_01920)	liaF	1969496..1970197 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DQL90_RS10120 (NCTC3761_01921)	-	1970212..1970598 (-)	387	WP_001110179.1	hypothetical protein	-
DQL90_RS10125 (NCTC3761_01922)	map	1970815..1971573 (-)	759	WP_000636144.1	type I methionyl aminopeptidase	-
DQL90_RS10135 (NCTC3761_01923)	-	1972104..1973090 (+)	987	WP_042727578.1	FUSC family protein	-
DQL90_RS10145 (NCTC3761_01924)	-	1973521..1973934 (-)	414	WP_001549145.1	hypothetical protein	-
DQL90_RS10150	-	1973963..1974073 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1136030 DQL90_RS10110 WP_001017131.1 1968456..1969499(-) (vraS) [Staphylococcus aureus strain NCTC3761]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1136030 DQL90_RS10110 WP_001017131.1 1968456..1969499(-) (vraS) [Staphylococcus aureus strain NCTC3761]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1