Detailed information NTG1135939

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DQL63_RS05030
• Genome accession: NZ_LS483312
• Coordinates: 1073704..1074747 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain NCTC7990
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1068704..1079747

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL63_RS05005 (NCTC7990_01013)	-	1068994..1070355 (-)	1362	WP_002461341.1	FAD-dependent oxidoreductase	-
DQL63_RS05010 (NCTC7990_01014)	-	1070489..1071469 (-)	981	WP_002461340.1	FUSC family protein	-
DQL63_RS05015 (NCTC7990_01015)	map	1071714..1072469 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
DQL63_RS05020 (NCTC7990_01016)	-	1072595..1072981 (+)	387	WP_002477960.1	hypothetical protein	-
DQL63_RS05025 (NCTC7990_01017)	liaF	1073006..1073707 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
DQL63_RS05030 (NCTC7990_01018)	vraS	1073704..1074747 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
DQL63_RS05035 (NCTC7990_01019)	vraR	1074737..1075366 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
DQL63_RS05040 (NCTC7990_01020)	-	1075539..1076768 (-)	1230	WP_002461332.1	YihY/virulence factor BrkB family protein	-
DQL63_RS05045 (NCTC7990_01021)	-	1076971..1077255 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
DQL63_RS05050 (NCTC7990_01022)	-	1077262..1077726 (-)	465	WP_002477961.1	low molecular weight protein-tyrosine-phosphatase	-
DQL63_RS05055 (NCTC7990_01023)	-	1077890..1078075 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
DQL63_RS05060 (NCTC7990_01024)	-	1078088..1079326 (+)	1239	WP_111703862.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=1135939 DQL63_RS05030 WP_002461334.1 1073704..1074747(+) (vraS) [Staphylococcus lugdunensis strain NCTC7990]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=1135939 DQL63_RS05030 WP_002461334.1 1073704..1074747(+) (vraS) [Staphylococcus lugdunensis strain NCTC7990]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911