Detailed information NTG1135923

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DQL83_RS10495
• Genome accession: NZ_LS483311
• Coordinates: 2012543..2013586 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NCTC6136
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2007543..2018586

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL83_RS10465 (NCTC6136_01967)	-	2007965..2009221 (-)	1257	WP_001789555.1	aminopeptidase	-
DQL83_RS10470 (NCTC6136_01968)	-	2009224..2009424 (-)	201	WP_000180460.1	DUF1128 family protein	-
DQL83_RS10475 (NCTC6136_01969)	-	2009571..2010035 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DQL83_RS10480 (NCTC6136_01970)	-	2010042..2010317 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DQL83_RS10485 (NCTC6136_01971)	-	2010595..2011812 (+)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
DQL83_RS10490 (NCTC6136_01972)	vraR	2011924..2012553 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
DQL83_RS10495 (NCTC6136_01973)	vraS	2012543..2013586 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DQL83_RS10500 (NCTC6136_01974)	liaF	2013583..2014284 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
DQL83_RS10505 (NCTC6136_01975)	-	2014299..2014685 (-)	387	WP_001110179.1	hypothetical protein	-
DQL83_RS10510 (NCTC6136_01976)	map	2014902..2015660 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
DQL83_RS10515 (NCTC6136_01977)	-	2016189..2017175 (+)	987	WP_000999713.1	FUSC family protein	-
DQL83_RS10525 (NCTC6136_01978)	-	2017606..2018019 (-)	414	WP_001670387.1	hypothetical protein	-
DQL83_RS10530	-	2018048..2018158 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1135923 DQL83_RS10495 WP_001017131.1 2012543..2013586(-) (vraS) [Staphylococcus aureus strain NCTC6136]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1135923 DQL83_RS10495 WP_001017131.1 2012543..2013586(-) (vraS) [Staphylococcus aureus strain NCTC6136]
ATGAACCACTATATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1