Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | DQL96_RS00535 | Genome accession | NZ_LS483309 |
| Coordinates | 105693..107039 (-) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus aureus strain NCTC9944 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 52598..107039 | 105693..107039 | within | 0 |
Gene organization within MGE regions
Location: 52598..107039
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DQL96_RS00210 (NCTC9944_00043) | ccrC | 52598..54277 (+) | 1680 | WP_016187646.1 | cassette chromosome recombinase CcrC | - |
| DQL96_RS00215 (NCTC9944_00044) | - | 54366..54704 (+) | 339 | WP_000175892.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| DQL96_RS00225 (NCTC9944_00046) | - | 54798..55109 (+) | 312 | WP_001166716.1 | DUF960 family protein | - |
| DQL96_RS00230 (NCTC9944_00047) | - | 55125..55631 (+) | 507 | WP_000848380.1 | DUF1643 domain-containing protein | - |
| DQL96_RS00235 (NCTC9944_00048) | - | 55652..55969 (+) | 318 | WP_000659046.1 | JAB domain-containing protein | - |
| DQL96_RS00240 (NCTC9944_00049) | - | 56088..57173 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| DQL96_RS00245 (NCTC9944_00050) | - | 57170..59062 (+) | 1893 | WP_111689280.1 | site-specific integrase | - |
| DQL96_RS00250 (NCTC9944_00051) | - | 59069..59446 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| DQL96_RS00255 | ant(9) | 59597..60379 (+) | 783 | Protein_44 | aminoglycoside nucleotidyltransferase ANT(9) | - |
| DQL96_RS00260 (NCTC9944_00054) | erm(A) | 60504..61235 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| DQL96_RS15955 | - | 61293..61379 (-) | 87 | WP_111689366.1 | erythromycin resistance leader peptide | - |
| DQL96_RS00275 (NCTC9944_00055) | - | 61743..62405 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| DQL96_RS15730 | - | 62637..62783 (+) | 147 | Protein_48 | JAB domain-containing protein | - |
| DQL96_RS00285 (NCTC9944_00056) | - | 62953..63825 (+) | 873 | WP_000373151.1 | HTH domain-containing protein | - |
| DQL96_RS00290 (NCTC9944_00057) | - | 63882..64172 (+) | 291 | WP_000065262.1 | hypothetical protein | - |
| DQL96_RS00295 (NCTC9944_00058) | - | 64188..64676 (+) | 489 | WP_000397419.1 | hypothetical protein | - |
| DQL96_RS00300 (NCTC9944_00059) | - | 64811..65338 (+) | 528 | WP_000717928.1 | hypothetical protein | - |
| DQL96_RS00305 (NCTC9944_00060) | - | 65400..65816 (+) | 417 | WP_000941331.1 | hypothetical protein | - |
| DQL96_RS15590 | - | 66105..66269 (+) | 165 | WP_001803222.1 | hypothetical protein | - |
| DQL96_RS00310 (NCTC9944_00061) | - | 66283..66504 (+) | 222 | WP_001070883.1 | hypothetical protein | - |
| DQL96_RS00315 (NCTC9944_00062) | - | 66654..67220 (+) | 567 | WP_000759939.1 | PepSY domain-containing protein | - |
| DQL96_RS00320 (NCTC9944_00063) | - | 67300..69513 (-) | 2214 | Protein_57 | type I restriction endonuclease subunit R | - |
| DQL96_RS00325 (NCTC9944_00064) | - | 69575..70249 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| DQL96_RS00330 (NCTC9944_00065) | - | 70532..71878 (+) | 1347 | WP_000163428.1 | dihydrolipoyl dehydrogenase family protein | - |
| DQL96_RS00335 (NCTC9944_00066) | merR | 72178..72585 (+) | 408 | WP_000425271.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| DQL96_RS00340 (NCTC9944_00067) | - | 72602..72955 (+) | 354 | WP_000746201.1 | TlpA family protein disulfide reductase | - |
| DQL96_RS00345 (NCTC9944_00068) | - | 72952..73632 (+) | 681 | WP_000010351.1 | cytochrome c biogenesis CcdA family protein | - |
| DQL96_RS00350 (NCTC9944_00069) | - | 73767..74105 (+) | 339 | WP_000968575.1 | hypothetical protein | - |
| DQL96_RS00355 (NCTC9944_00070) | merA | 74163..75806 (+) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| DQL96_RS00360 (NCTC9944_00071) | merB | 75888..76538 (+) | 651 | WP_000790334.1 | organomercurial lyase MerB | - |
| DQL96_RS15925 | - | 76733..77263 (-) | 531 | Protein_66 | hypothetical protein | - |
| DQL96_RS00375 (NCTC9944_00073) | - | 77299..77973 (-) | 675 | WP_001106055.1 | IS6-like element IS257 family transposase | - |
| DQL96_RS00380 (NCTC9944_00074) | tet(K) | 78170..79549 (+) | 1380 | WP_000492283.1 | tetracycline efflux MFS transporter Tet(K) | - |
| DQL96_RS00385 (NCTC9944_00075) | mobV | 79735..80976 (+) | 1242 | WP_000122374.1 | MobV family relaxase | - |
| DQL96_RS00390 (NCTC9944_00077) | - | 81503..82457 (+) | 955 | Protein_70 | replication initiation factor domain-containing protein | - |
| DQL96_RS00395 (NCTC9944_00078) | - | 82546..83220 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| DQL96_RS00400 | - | 83256..83645 (+) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| DQL96_RS00410 (NCTC9944_00080) | - | 84562..85305 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| DQL96_RS00415 (NCTC9944_00081) | - | 85402..85830 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| DQL96_RS00420 (NCTC9944_00082) | mecA | 85876..87885 (-) | 2010 | WP_078056515.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| DQL96_RS00425 (NCTC9944_00083) | mecR1 | 87982..89739 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| DQL96_RS00430 | mecI | 89739..90110 (+) | 372 | Protein_77 | mecA-type methicillin resistance repressor MecI | - |
| DQL96_RS00435 | psm-mec | 90195..90263 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| DQL96_RS00440 (NCTC9944_00085) | - | 90583..91731 (+) | 1149 | WP_000427807.1 | ROK family transcriptional regulator | - |
| DQL96_RS00450 (NCTC9944_00087) | cstB | 91845..93179 (-) | 1335 | Protein_80 | persulfide dioxygenase-sulfurtransferase CstB | - |
| DQL96_RS00455 (NCTC9944_00088) | - | 93212..94276 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| DQL96_RS00460 (NCTC9944_00089) | cstR | 94412..94672 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| DQL96_RS00465 (NCTC9944_00090) | - | 94672..95310 (+) | 639 | Protein_83 | sulfite exporter TauE/SafE family protein | - |
| DQL96_RS00475 (NCTC9944_00091) | - | 95584..96201 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| DQL96_RS00480 (NCTC9944_00092) | - | 96282..98696 (-) | 2415 | WP_111689282.1 | cadmium-translocating P-type ATPase CadA | - |
| DQL96_RS00485 (NCTC9944_00093) | - | 98689..99054 (-) | 366 | WP_000159127.1 | ArsR/SmtB family transcription factor | - |
| DQL96_RS00490 (NCTC9944_00094) | - | 99292..99669 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| DQL96_RS00495 (NCTC9944_00095) | - | 99676..101568 (-) | 1893 | WP_111689280.1 | site-specific integrase | - |
| DQL96_RS00500 (NCTC9944_00096) | - | 101763..102086 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| DQL96_RS00505 (NCTC9944_00097) | - | 102079..102285 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| DQL96_RS00510 (NCTC9944_00098) | - | 102287..102808 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| DQL96_RS00515 (NCTC9944_00099) | - | 102827..103138 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| DQL96_RS00525 (NCTC9944_00101) | - | 103223..103573 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| DQL96_RS00530 (NCTC9944_00102) | ccrB | 104044..105672 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| DQL96_RS00535 (NCTC9944_00103) | ccrA | 105693..107039 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=1135850 DQL96_RS00535 WP_000816499.1 105693..107039(-) (ccrA) [Staphylococcus aureus strain NCTC9944]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=1135850 DQL96_RS00535 WP_000816499.1 105693..107039(-) (ccrA) [Staphylococcus aureus strain NCTC9944]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |