Detailed information NTG1135787

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL09_RS06875
• Genome accession: NZ_LS483307
• Coordinates: 1290907..1291944 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC5163
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1285907..1296944

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL09_RS06855 (NCTC5163_01377)	-	1286658..1287284 (+)	627	WP_111677367.1	prepilin peptidase	-
DQL09_RS06860 (NCTC5163_01378)	rlmN	1287366..1288445 (-)	1080	WP_011184761.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQL09_RS06865 (NCTC5163_01379)	-	1288449..1289069 (-)	621	WP_002992791.1	YutD family protein	-
DQL09_RS06870 (NCTC5163_01381)	-	1289516..1290493 (-)	978	WP_011054718.1	LacI family DNA-binding transcriptional regulator	-
DQL09_RS06875 (NCTC5163_01382)	sepM	1290907..1291944 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
DQL09_RS06880 (NCTC5163_01383)	coaD	1291931..1292422 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQL09_RS06885 (NCTC5163_01384)	rsmD	1292412..1292951 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL09_RS06890 (NCTC5163_01385)	asnA	1293074..1294066 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQL09_RS06895 (NCTC5163_01386)	arcC	1294379..1295329 (-)	951	WP_111677368.1	carbamate kinase	-
DQL09_RS06900 (NCTC5163_01387)	-	1295349..1296680 (-)	1332	WP_111677369.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1135787 DQL09_RS06875 WP_010922499.1 1290907..1291944(-) (sepM) [Streptococcus pyogenes strain NCTC5163]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1135787 DQL09_RS06875 WP_010922499.1 1290907..1291944(-) (sepM) [Streptococcus pyogenes strain NCTC5163]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693