Detailed information NTG1135574

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DQL88_RS10780
• Genome accession: NZ_LS483301
• Coordinates: 2062808..2063851 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NCTC13394
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2057808..2068851

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL88_RS10750 (NCTC13394_01992)	-	2058226..2059482 (-)	1257	WP_001795438.1	aminopeptidase	-
DQL88_RS10755 (NCTC13394_01993)	-	2059485..2059685 (-)	201	WP_000180461.1	DUF1128 family protein	-
DQL88_RS10760 (NCTC13394_01994)	-	2059832..2060296 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
DQL88_RS10765 (NCTC13394_01995)	-	2060303..2060578 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DQL88_RS10770 (NCTC13394_01996)	-	2060856..2062073 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
DQL88_RS10775 (NCTC13394_01997)	vraR	2062189..2062818 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
DQL88_RS10780 (NCTC13394_01998)	vraS	2062808..2063851 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DQL88_RS10785 (NCTC13394_01999)	liaF	2063848..2064549 (-)	702	WP_001622130.1	cell wall-active antibiotics response protein LiaF	-
DQL88_RS10790 (NCTC13394_02000)	-	2064564..2064950 (-)	387	WP_001110179.1	hypothetical protein	-
DQL88_RS10795 (NCTC13394_02001)	map	2065167..2065925 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
DQL88_RS10805 (NCTC13394_02002)	-	2066512..2067498 (+)	987	WP_000999713.1	FUSC family protein	-
DQL88_RS10815 (NCTC13394_02003)	-	2067929..2068342 (-)	414	WP_001549145.1	hypothetical protein	-
DQL88_RS10820	-	2068371..2068481 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1135574 DQL88_RS10780 WP_001017131.1 2062808..2063851(-) (vraS) [Staphylococcus aureus strain NCTC13394]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1135574 DQL88_RS10780 WP_001017131.1 2062808..2063851(-) (vraS) [Staphylococcus aureus strain NCTC13394]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTACATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1