Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrB   Type   Machinery gene
Locus tag   DQL88_RS00375 Genome accession   NZ_LS483301
Coordinates   72489..74117 (-) Length   542 a.a.
NCBI ID   WP_001631035.1    Uniprot ID   -
Organism   Staphylococcus aureus strain NCTC13394     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 38165..79897 72489..74117 within 0


Gene organization within MGE regions


Location: 38165..79897
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL88_RS00170 (NCTC13394_00034) mecA 38165..40174 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  DQL88_RS00175 (NCTC13394_00035) mecR1 40271..42028 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  DQL88_RS00180 (NCTC13394_00036) - 42028..42279 (+) 252 Protein_31 BlaI/MecI/CopY family transcriptional regulator -
  DQL88_RS00185 (NCTC13394_00037) - 42384..43988 (-) 1605 WP_000284571.1 IS1182-like element IS1182 family transposase -
  DQL88_RS00190 - 44142..44249 (+) 108 Protein_33 BlaI/MecI/CopY family transcriptional regulator -
  DQL88_RS00195 psm-mec 44334..44402 (-) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  DQL88_RS00200 (NCTC13394_00038) - 44736..45866 (+) 1131 WP_010922808.1 ROK family transcriptional regulator -
  DQL88_RS00210 (NCTC13394_00040) cstB 45980..47314 (-) 1335 Protein_36 persulfide dioxygenase-sulfurtransferase CstB -
  DQL88_RS00215 (NCTC13394_00041) - 47347..48411 (-) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  DQL88_RS00220 (NCTC13394_00042) cstR 48547..48807 (+) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  DQL88_RS00225 (NCTC13394_00043) - 48807..49445 (+) 639 Protein_39 sulfite exporter TauE/SafE family protein -
  DQL88_RS00235 (NCTC13394_00044) - 49790..50452 (-) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  DQL88_RS15900 - 50844..50903 (+) 60 WP_010959190.1 erythromycin resistance leader peptide -
  DQL88_RS00250 (NCTC13394_00045) erm(A) 50986..51717 (+) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  DQL88_RS00255 (NCTC13394_00046) - 51843..52625 (-) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  DQL88_RS00260 (NCTC13394_00047) - 52776..53153 (-) 378 WP_000361059.1 DUF6262 family protein -
  DQL88_RS00265 (NCTC13394_00048) - 53160..55052 (-) 1893 WP_001557544.1 site-specific integrase -
  DQL88_RS00270 (NCTC13394_00049) - 55049..56134 (-) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  DQL88_RS00275 (NCTC13394_00050) - 56253..56570 (-) 318 WP_000659050.1 JAB domain-containing protein -
  DQL88_RS00280 (NCTC13394_00051) - 56591..57097 (-) 507 WP_001092169.1 DUF1643 domain-containing protein -
  DQL88_RS00285 (NCTC13394_00052) - 57115..57426 (-) 312 WP_000700853.1 DUF960 family protein -
  DQL88_RS00290 (NCTC13394_00054) - 57513..57863 (-) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  DQL88_RS00295 (NCTC13394_00055) ccrB 58381..60009 (-) 1629 WP_001186602.1 cassette chromosome recombinase CcrB Machinery gene
  DQL88_RS00300 (NCTC13394_00056) ccrA 60031..61380 (-) 1350 WP_061731575.1 cassette chromosome recombinase CcrA Machinery gene
  DQL88_RS00305 (NCTC13394_00057) cch1 61614..63404 (-) 1791 WP_061731576.1 cassette chromosome replicative helicase -
  DQL88_RS00310 (NCTC13394_00058) - 63524..64954 (-) 1431 WP_001008608.1 DUF6038 family protein -
  DQL88_RS00315 (NCTC13394_00059) - 65071..65841 (+) 771 WP_000767841.1 DUF6414 family protein -
  DQL88_RS00320 (NCTC13394_00060) - 65825..66754 (+) 930 WP_231923532.1 AAA family ATPase -
  DQL88_RS00325 (NCTC13394_00061) - 67083..67226 (+) 144 WP_001631028.1 restriction endonuclease subunit R -
  DQL88_RS00330 (NCTC13394_00062) - 67219..68421 (+) 1203 WP_061731577.1 restriction endonuclease subunit S -
  DQL88_RS00335 - 68425..68685 (-) 261 Protein_59 IS5/IS1182 family transposase -
  DQL88_RS00340 (NCTC13394_00063) - 68744..69241 (-) 498 WP_001631030.1 GNAT family N-acetyltransferase -
  DQL88_RS00350 (NCTC13394_00064) - 69913..70323 (-) 411 WP_001631031.1 DUF2871 domain-containing protein -
  DQL88_RS15655 - 70486..70706 (-) 221 Protein_62 hypothetical protein -
  DQL88_RS00360 (NCTC13394_00065) - 70721..71224 (-) 504 WP_001631032.1 DUF1643 domain-containing protein -
  DQL88_RS00365 (NCTC13394_00066) - 71240..71551 (-) 312 WP_001631033.1 DUF960 domain-containing protein -
  DQL88_RS00370 (NCTC13394_00068) - 71638..71988 (-) 351 WP_001631034.1 SAUGI family uracil-DNA glycosylase inhibitor -
  DQL88_RS00375 (NCTC13394_00069) ccrB 72489..74117 (-) 1629 WP_001631035.1 cassette chromosome recombinase CcrB Machinery gene
  DQL88_RS00380 (NCTC13394_00070) ccrA 74114..75475 (-) 1362 WP_001631036.1 cassette chromosome recombinase CcrA Machinery gene
  DQL88_RS00385 (NCTC13394_00071) - 75662..76291 (-) 630 Protein_68 hypothetical protein -
  DQL88_RS00390 - 76300..76638 (+) 339 Protein_69 recombinase family protein -
  DQL88_RS00395 (NCTC13394_00073) - 76750..77109 (-) 360 WP_001631039.1 hypothetical protein -
  DQL88_RS00400 (NCTC13394_00074) - 77316..77642 (+) 327 WP_000391495.1 ArsR/SmtB family transcription factor -
  DQL88_RS00410 (NCTC13394_00076) - 77972..79897 (+) 1926 WP_002485723.1 heavy metal translocating P-type ATPase -

Sequence

Protein


Download         Length: 542 a.a.        Molecular weight: 62474.71 Da        Isoelectric Point: 9.6103

>NTDB_id=1135541 DQL88_RS00375 WP_001631035.1 72489..74117(-) (ccrB) [Staphylococcus aureus strain NCTC13394]
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE

Nucleotide


Download         Length: 1629 bp        

>NTDB_id=1135541 DQL88_RS00375 WP_001631035.1 72489..74117(-) (ccrB) [Staphylococcus aureus strain NCTC13394]
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATCGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA

Domains

Predicted by InterproScan.

Ogr/Delta-like zinc finger (Ogr_Delta)

(300-355)

Resolvase, N terminal domain (Resolvase)

(11-154)

Recombinase (Recombinase)

(179-280)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrB Staphylococcus aureus N315

72.694

100

0.727

Multiple sequence alignment