Detailed information NTG1135530

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DQL62_RS09815
• Genome accession: NZ_LS483300
• Coordinates: 1912222..1913265 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NCTC7485
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1907222..1918265

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL62_RS09785 (NCTC7485_01860)	-	1907643..1908899 (-)	1257	WP_078062667.1	aminopeptidase	-
DQL62_RS09790 (NCTC7485_01861)	-	1908902..1909102 (-)	201	WP_011382336.1	DUF1128 family protein	-
DQL62_RS09795 (NCTC7485_01862)	-	1909249..1909713 (+)	465	WP_000228664.1	low molecular weight protein-tyrosine-phosphatase	-
DQL62_RS09800 (NCTC7485_01863)	-	1909720..1909995 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
DQL62_RS09805 (NCTC7485_01864)	-	1910273..1911490 (+)	1218	WP_045158466.1	YihY/virulence factor BrkB family protein	-
DQL62_RS09810 (NCTC7485_01865)	vraR	1911603..1912232 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
DQL62_RS09815 (NCTC7485_01866)	vraS	1912222..1913265 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
DQL62_RS09820 (NCTC7485_01867)	liaF	1913262..1913963 (-)	702	WP_000149062.1	cell wall-active antibiotics response protein LiaF	-
DQL62_RS09825 (NCTC7485_01868)	-	1913978..1914364 (-)	387	WP_001110179.1	hypothetical protein	-
DQL62_RS09830 (NCTC7485_01869)	map	1914581..1915339 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
DQL62_RS09835 (NCTC7485_01870)	-	1915751..1916737 (+)	987	WP_000999713.1	FUSC family protein	-
DQL62_RS09840 (NCTC7485_01871)	-	1917167..1917580 (-)	414	WP_011382337.1	hypothetical protein	-
DQL62_RS09845	-	1917609..1917719 (-)	111	WP_042852778.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1135530 DQL62_RS09815 WP_001017131.1 1912222..1913265(-) (vraS) [Staphylococcus aureus strain NCTC7485]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1135530 DQL62_RS09815 WP_001017131.1 1912222..1913265(-) (vraS) [Staphylococcus aureus strain NCTC7485]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTGTTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTACTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTGCAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1