Detailed information NTG1135468

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQM39_RS03595
• Genome accession: NZ_LS483298
• Coordinates: 663853..664890 (+)
• Length: 345 a.a.
• NCBI ID: WP_002983824.1
• Uniprot ID: A0A4U9C0Q7
• Organism: Streptococcus pyogenes strain NCTC8225
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 658853..669890

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM39_RS03570 (NCTC8225_00713)	-	659117..660448 (+)	1332	WP_002983812.1	dipeptidase	-
DQM39_RS03575 (NCTC8225_00714)	arcC	660468..661418 (+)	951	WP_002983814.1	carbamate kinase	-
DQM39_RS03580 (NCTC8225_00715)	asnA	661731..662723 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
DQM39_RS03585 (NCTC8225_00716)	rsmD	662846..663385 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQM39_RS03590 (NCTC8225_00717)	coaD	663375..663866 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
DQM39_RS03595 (NCTC8225_00718)	sepM	663853..664890 (+)	1038	WP_002983824.1	SepM family pheromone-processing serine protease	Regulator
DQM39_RS03600 (NCTC8225_00719)	-	665304..666281 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
DQM39_RS03605 (NCTC8225_00721)	-	666729..667349 (+)	621	WP_032467263.1	YutD family protein	-
DQM39_RS03610 (NCTC8225_00722)	rlmN	667353..668432 (+)	1080	WP_111680790.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
DQM39_RS03615 (NCTC8225_00723)	-	668514..669140 (-)	627	WP_002983834.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37555.27 Da
• Isoelectric Point: 9.6692

>NTDB_id=1135468 DQM39_RS03595 WP_002983824.1 663853..664890(+) (sepM) [Streptococcus pyogenes strain NCTC8225]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTIQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1135468 DQM39_RS03595 WP_002983824.1 663853..664890(+) (sepM) [Streptococcus pyogenes strain NCTC8225]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGATTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9C0Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	68.986	100	0.69