Detailed information    

insolico Bioinformatically predicted

Overview

Name   sepM   Type   Regulator
Locus tag   H1W86_RS07560 Genome accession   NZ_LR822042
Coordinates   1463118..1464194 (-) Length   358 a.a.
NCBI ID   WP_011681549.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_1358     
Function   processing of CSP (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1448386..1521189 1463118..1464194 within 0


Gene organization within MGE regions


Location: 1448386..1521189
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W86_RS07495 (STHERMO_1649) - 1449277..1449828 (-) 552 WP_002946999.1 cysteine hydrolase family protein -
  H1W86_RS07500 (STHERMO_1650) codY 1449891..1450676 (-) 786 WP_002951720.1 GTP-sensing pleiotropic transcriptional regulator CodY -
  H1W86_RS07505 (STHERMO_1651) - 1450936..1452150 (-) 1215 WP_002951721.1 pyridoxal phosphate-dependent aminotransferase -
  H1W86_RS07510 (STHERMO_1652) - 1452505..1452957 (+) 453 WP_002946987.1 universal stress protein -
  H1W86_RS09815 - 1453137..1453708 (+) 572 Protein_1444 IS30 family transposase -
  H1W86_RS09820 (STHERMO_1655) - 1453780..1454376 (-) 597 WP_232086461.1 hypothetical protein -
  H1W86_RS07520 (STHERMO_1657) pflA 1454588..1455388 (-) 801 WP_002946980.1 pyruvate formate-lyase-activating protein -
  H1W86_RS07525 - 1455576..1455686 (-) 111 WP_014621906.1 LPXTG cell wall anchor domain-containing protein -
  H1W86_RS07530 (STHERMO_1659) - 1456384..1457715 (-) 1332 WP_002946973.1 hemolysin family protein -
  H1W86_RS07535 (STHERMO_1660) - 1457826..1458608 (+) 783 WP_011226459.1 ABC transporter ATP-binding protein -
  H1W86_RS07540 (STHERMO_1662) - 1459230..1461296 (-) 2067 WP_179971428.1 cation:proton antiporter -
  H1W86_RS07545 (STHERMO_1663) - 1461305..1461547 (-) 243 WP_011226461.1 hypothetical protein -
  H1W86_RS07550 (STHERMO_1664) - 1461544..1462092 (-) 549 WP_011226462.1 tRNA (mnm(5)s(2)U34)-methyltransferase -
  H1W86_RS07555 (STHERMO_1665) - 1462089..1463033 (-) 945 WP_180479508.1 TIGR01212 family radical SAM protein -
  H1W86_RS07560 (STHERMO_1666) sepM 1463118..1464194 (-) 1077 WP_011681549.1 SepM family pheromone-processing serine protease Regulator
  H1W86_RS07565 (STHERMO_1667) coaD 1464172..1464669 (-) 498 WP_011681550.1 pantetheine-phosphate adenylyltransferase -
  H1W86_RS07570 (STHERMO_1668) rsmD 1464703..1465302 (-) 600 Protein_1456 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  H1W86_RS07575 (STHERMO_1669) trxB 1465393..1466346 (-) 954 WP_255136104.1 thioredoxin-disulfide reductase -
  H1W86_RS07580 (STHERMO_1670) - 1466379..1466603 (-) 225 WP_014621911.1 DUF4059 family protein -
  H1W86_RS07585 (STHERMO_1671) - 1466818..1467561 (-) 744 WP_014608652.1 amino acid ABC transporter ATP-binding protein -
  H1W86_RS07590 (STHERMO_1672) - 1467561..1468307 (-) 747 WP_100284797.1 amino acid ABC transporter permease -
  H1W86_RS07595 (STHERMO_1673) - 1468695..1469525 (-) 831 WP_014608653.1 transporter substrate-binding domain-containing protein -
  H1W86_RS07600 (STHERMO_1675) - 1469985..1470218 (-) 234 WP_002947030.1 hypothetical protein -
  H1W86_RS07605 (STHERMO_1676) dinB 1470516..1471619 (-) 1104 WP_014608654.1 DNA polymerase IV -
  H1W86_RS07610 (STHERMO_1677) pflB 1471898..1474207 (+) 2310 WP_011226473.1 formate C-acetyltransferase -
  H1W86_RS07615 (STHERMO_1678) - 1474474..1475256 (+) 783 WP_180479510.1 carbonic anhydrase -
  H1W86_RS07620 (STHERMO_1679) - 1475307..1475759 (+) 453 WP_180479734.1 GNAT family N-acetyltransferase -
  H1W86_RS07625 (STHERMO_1680) - 1476110..1476394 (-) 285 WP_014608656.1 restriction endonuclease subunit S -
  H1W86_RS10140 (STHERMO_1682) mobV 1476440..1476948 (-) 509 Protein_1468 MobV family relaxase -
  H1W86_RS07635 (STHERMO_1684) - 1477393..1478148 (-) 756 WP_011681558.1 ABC transporter permease -
  H1W86_RS07640 (STHERMO_1685) - 1478145..1478795 (-) 651 WP_011681559.1 ATP-binding cassette domain-containing protein -
  H1W86_RS07645 (STHERMO_1687) - 1478998..1479954 (-) 957 WP_002951776.1 serine hydrolase domain-containing protein -
  H1W86_RS07650 (STHERMO_1688) - 1479954..1480709 (-) 756 WP_011681560.1 CppA family protein -
  H1W86_RS07655 (STHERMO_1689) - 1480991..1481353 (+) 363 WP_014608659.1 CPBP family intramembrane glutamic endopeptidase -
  H1W86_RS07660 (STHERMO_1690) gla 1481440..1482303 (-) 864 WP_002951781.1 aquaglyceroporin Gla -
  H1W86_RS07665 (STHERMO_1691) - 1482424..1484691 (+) 2268 WP_179970581.1 Xaa-Pro dipeptidyl-peptidase -
  H1W86_RS07670 (STHERMO_1692) - 1484771..1485151 (-) 381 WP_002951783.1 hypothetical protein -
  H1W86_RS07675 - 1485276..1485539 (-) 264 WP_002945924.1 hypothetical protein -
  H1W86_RS07680 (STHERMO_1695) - 1485861..1486157 (-) 297 WP_004197070.1 bacteriocin immunity protein -
  H1W86_RS07685 (STHERMO_1696) - 1486322..1487248 (-) 927 WP_022096485.1 thioredoxin family protein -
  H1W86_RS07690 - 1487442..1489012 (+) 1571 WP_087009847.1 IS3-like element ISSth1b family transposase -
  H1W86_RS07695 (STHERMO_1699) - 1489158..1489424 (-) 267 WP_179970580.1 bacteriocin -
  H1W86_RS10145 (STHERMO_1700) - 1489675..1490076 (-) 402 WP_024703992.1 hypothetical protein -
  H1W86_RS07700 (STHERMO_1704) - 1491081..1491311 (-) 231 WP_014608662.1 bacteriocin class II family protein -
  H1W86_RS07705 (STHERMO_1705) - 1491667..1491867 (-) 201 WP_011681569.1 hypothetical protein -
  H1W86_RS07710 (STHERMO_1706) - 1491886..1492062 (-) 177 WP_011681570.1 Blp family class II bacteriocin -
  H1W86_RS07715 (STHERMO_1707) - 1492318..1493055 (+) 738 WP_064356014.1 LytR/AlgR family response regulator transcription factor -
  H1W86_RS09830 - 1493586..1494389 (+) 804 WP_223899638.1 ATP-binding protein -
  H1W86_RS07725 (STHERMO_1709) - 1494407..1494568 (-) 162 WP_011681573.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  H1W86_RS07730 (STHERMO_1710) - 1494583..1495950 (-) 1368 WP_011681574.1 bacteriocin secretion accessory protein -
  H1W86_RS07735 (STHERMO_1711) comA/nlmT 1495966..1498119 (-) 2154 WP_041827378.1 peptide cleavage/export ABC transporter Regulator
  H1W86_RS07740 (STHERMO_1715) - 1499133..1500878 (-) 1746 WP_024703994.1 ABC transporter ATP-binding protein -
  H1W86_RS07745 (STHERMO_1716) - 1500871..1502628 (-) 1758 WP_180479512.1 ABC transporter ATP-binding protein -
  H1W86_RS09835 (STHERMO_1718) - 1502816..1503022 (-) 207 WP_002948879.1 hypothetical protein -
  H1W86_RS07755 (STHERMO_1720) - 1503227..1503754 (-) 528 WP_011226503.1 VanZ family protein -
  H1W86_RS07760 (STHERMO_1721) rlmN 1503756..1504925 (-) 1170 WP_011226504.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  H1W86_RS07765 (STHERMO_1722) - 1504929..1505651 (-) 723 WP_011226505.1 YutD family protein -
  H1W86_RS07770 (STHERMO_1723) - 1505706..1507061 (-) 1356 WP_002948886.1 bifunctional metallophosphatase/5'-nucleotidase -
  H1W86_RS07775 (STHERMO_1726) - 1507909..1509252 (-) 1344 WP_014608670.1 DEAD/DEAH box helicase -
  H1W86_RS07780 (STHERMO_1727) mraY 1509327..1510349 (-) 1023 WP_011227524.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
  H1W86_RS07785 (STHERMO_1728) pbp2X 1510351..1512618 (-) 2268 WP_011226508.1 penicillin-binding protein PBP2X -
  H1W86_RS07790 (STHERMO_1729) ftsL 1512622..1512942 (-) 321 WP_014608671.1 cell division protein FtsL -
  H1W86_RS07795 (STHERMO_1730) rsmH 1512945..1513895 (-) 951 WP_002888254.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -
  H1W86_RS07800 (STHERMO_1731) - 1514062..1514793 (-) 732 WP_224103288.1 hypothetical protein -
  H1W86_RS07810 (STHERMO_1733) - 1515122..1515385 (+) 264 WP_162877224.1 hypothetical protein -
  H1W86_RS07815 (STHERMO_1735) - 1515691..1516047 (-) 357 WP_023909925.1 DUF805 domain-containing protein -
  H1W86_RS07820 (STHERMO_1736) - 1516396..1516563 (-) 168 WP_153300736.1 hypothetical protein -
  H1W86_RS07825 (STHERMO_1737) - 1516896..1518146 (-) 1251 WP_014608675.1 glutamate-5-semialdehyde dehydrogenase -
  H1W86_RS07830 (STHERMO_1738) proB 1518148..1518951 (-) 804 WP_014608676.1 glutamate 5-kinase -
  H1W86_RS07835 (STHERMO_1739) - 1519072..1520661 (-) 1590 WP_014608677.1 ABC transporter permease -

Sequence

Protein


Download         Length: 358 a.a.        Molecular weight: 39172.02 Da        Isoelectric Point: 9.3888

>NTDB_id=1132138 H1W86_RS07560 WP_011681549.1 1463118..1464194(-) (sepM) [Streptococcus thermophilus isolate STH_CIRM_1358]
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK

Nucleotide


Download         Length: 1077 bp        

>NTDB_id=1132138 H1W86_RS07560 WP_011681549.1 1463118..1464194(-) (sepM) [Streptococcus thermophilus isolate STH_CIRM_1358]
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(137-206)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sepM Streptococcus mutans UA159

62.757

95.251

0.598

Multiple sequence alignment