Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   H1W80_RS03015 Genome accession   NZ_LR822040
Coordinates   559995..562253 (-) Length   752 a.a.
NCBI ID   WP_180473453.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_1125     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 554995..567253
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W80_RS02985 (STHERMO_0626) - 555393..555893 (+) 501 WP_232086565.1 DUF3862 domain-containing protein -
  H1W80_RS09795 (STHERMO_0627) - 555890..556012 (+) 123 WP_260232014.1 hypothetical protein -
  H1W80_RS02990 (STHERMO_0628) - 556275..556766 (+) 492 WP_231906221.1 TVP38/TMEM64 family protein -
  H1W80_RS02995 (STHERMO_0629) - 556744..557979 (+) 1236 WP_087009774.1 aminoacyltransferase -
  H1W80_RS03000 - 558078..559002 (+) 925 Protein_526 Gfo/Idh/MocA family protein -
  H1W80_RS03005 (STHERMO_0634) - 559082..559384 (-) 303 WP_084829456.1 DUF1827 family protein -
  H1W80_RS03010 (STHERMO_0635) - 559394..559852 (-) 459 WP_002947302.1 NUDIX hydrolase -
  H1W80_RS03015 (STHERMO_0636) clpE 559995..562253 (-) 2259 WP_180473453.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  H1W80_RS03020 (STHERMO_0637) argF 562494..563474 (+) 981 WP_011680919.1 ornithine carbamoyltransferase -
  H1W80_RS03025 (STHERMO_0638) - 563543..563773 (+) 231 WP_011225686.1 DUF1797 family protein -
  H1W80_RS03030 (STHERMO_0639) - 564042..564722 (+) 681 WP_014608117.1 amino acid ABC transporter permease -
  H1W80_RS03035 (STHERMO_0640) - 564722..565456 (+) 735 WP_011225688.1 amino acid ABC transporter ATP-binding protein -
  H1W80_RS03040 (STHERMO_0641) - 565630..566106 (+) 477 WP_014608118.1 ferrous iron transport protein A -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83784.98 Da        Isoelectric Point: 5.2761

>NTDB_id=1131994 H1W80_RS03015 WP_180473453.1 559995..562253(-) (clpE) [Streptococcus thermophilus isolate STH_CIRM_1125]
MLCQNCNLNEASIHLYTNVNGNQQQVDLCQHCYKIIKSDPENPLNQFNQAGGSNFFDDFFSDLNNFRSSNGDLPNTPPTQ
EGGNRGNGGPGRPGGPRQQAPQQPQGLLEEFGINITDIARRGDIDPVIGRDEEIIRVIEILNRRTKNNPVLIGEPGVGKT
AVVEGLAQKIVDGDVPQKLQSKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVGAGNTGDGNM
DAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILRGIQPKYQDYHHVKYTDEAITAAA
ELSNRYIQDRFLPDKAIDLLDESGSKMNLTLNFIDPKDLDKRLIEAENLKAQATRDEDFEKAAYFRDQIAKYKEMQQQTI
KDQDMPIITEKHIEAIVEQKTNIPIGDLKEKEQSQLLNLADDLKAHVIGQDAAVDKIAKAIRRNRVGLGAPNRPIGSFLF
VGPTGVGKTELSKQLAIELFGSSDSMIRFDMSEYMEKHAVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDEVEKAH
PDVLHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAARENRTNSVINHLGDFFSPEFMNRFDGIIE
FSALSKENLLTIVDLMLDGVNRRLANNGIHLSVTDKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLKNPNEKDL
KAVMTSKGHITIKSAKKTEKTSQKTEALKEVN

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=1131994 H1W80_RS03015 WP_180473453.1 559995..562253(-) (clpE) [Streptococcus thermophilus isolate STH_CIRM_1125]
ATGCTCTGCCAAAACTGTAACCTTAATGAAGCTAGTATCCATTTGTATACCAACGTAAATGGTAATCAGCAACAAGTTGA
CCTCTGTCAACATTGTTATAAAATCATAAAATCTGATCCAGAGAACCCCCTTAACCAATTCAATCAAGCAGGAGGTTCCA
ACTTCTTCGACGATTTCTTCAGTGACCTAAACAACTTCCGTTCTTCTAACGGAGACCTTCCTAATACACCTCCAACACAA
GAGGGAGGTAACCGTGGAAACGGTGGTCCAGGCCGTCCTGGAGGACCACGTCAACAAGCCCCTCAACAACCTCAAGGTCT
TCTCGAAGAATTTGGAATTAATATCACAGATATTGCTCGTCGTGGAGACATTGATCCTGTCATTGGTCGTGACGAAGAAA
TCATTCGCGTCATCGAAATTCTGAACCGCCGTACCAAGAACAATCCTGTTCTTATCGGTGAACCTGGTGTTGGTAAGACC
GCAGTAGTCGAAGGACTTGCCCAAAAAATCGTTGATGGAGATGTGCCACAAAAACTCCAAAGCAAGCAAGTTATCCGTCT
TGATGTTGTAAGCCTAGTTCAAGGGACTGGTATCCGCGGCCAGTTCGAAGAACGCATGCAAAAGCTCATGGAGGAAATCC
GCCAACGTCAGGATGTTATCCTCTTTATTGATGAAATCCATGAAATTGTAGGAGCTGGTAATACTGGGGACGGCAATATG
GATGCTGGAAACATCTTAAAACCTGCACTTGCCCGTGGAGAGCTTCAACTTGTTGGAGCAACAACACTCAACGAATACCG
TATCATTGAGAAAGATGCGGCACTCGAACGTCGTATGCAACCTGTTAAGGTAGATGAGCCAACAGTTGAGGAAACAATCA
CAATTTTGCGTGGTATCCAGCCTAAATATCAAGACTACCACCATGTCAAATACACTGATGAAGCCATTACTGCAGCTGCA
GAATTATCCAACCGCTACATTCAGGACCGTTTCTTGCCAGACAAGGCCATCGACCTTCTCGATGAATCTGGCTCTAAGAT
GAATTTAACCCTCAACTTTATCGATCCTAAGGACCTCGATAAACGCTTGATTGAAGCTGAGAATCTTAAAGCTCAGGCTA
CTCGTGACGAAGACTTTGAAAAAGCTGCTTATTTCCGTGACCAAATTGCTAAATACAAGGAAATGCAACAGCAAACCATC
AAAGACCAAGATATGCCTATCATTACTGAAAAACATATCGAAGCCATTGTCGAGCAAAAAACCAATATTCCTATCGGTGA
TTTAAAAGAAAAAGAACAATCTCAACTTCTCAACCTCGCCGATGACCTTAAGGCGCATGTTATTGGCCAAGATGCCGCAG
TTGATAAGATTGCCAAAGCTATCCGCCGTAATCGTGTTGGACTTGGTGCACCAAACCGCCCAATTGGTAGCTTCCTATTT
GTAGGCCCTACAGGAGTCGGTAAAACTGAGCTCTCTAAACAGTTAGCCATCGAGCTCTTTGGTTCATCTGATAGTATGAT
TCGTTTTGACATGTCAGAATACATGGAAAAACACGCTGTTGCTAAATTGGTCGGTGCTCCTCCAGGCTATGTTGGTTACG
ACGAAGCTGGGCAATTAACCGAAAAGGTCCGCCGTAACCCTTATTCACTCATTCTCCTTGATGAGGTTGAAAAAGCTCAC
CCAGATGTGCTTCACATGTTCCTTCAGGTACTTGACGATGGTCGTCTGACTGATGGTCAAGGGAGAACTGTAAGTTTCAA
AGATACCATCATCATCATGACTTCAAATGCTGGTACTGGTAAAGTGGAAGCAAGTGTAGGTTTTGGAGCTGCTCGTGAGA
ATCGTACCAATTCTGTTATCAACCACCTTGGAGATTTCTTCAGTCCTGAATTCATGAACCGTTTTGACGGTATTATCGAG
TTCTCTGCCCTAAGCAAGGAAAATCTCCTTACTATCGTGGATCTTATGCTTGATGGCGTCAACCGACGCTTGGCAAACAA
CGGTATCCACCTCAGTGTGACTGATAAAGTTAAGGAAAAACTGGTTGACCTTGGTTATGATCCTAAGATGGGTGCTCGAC
CATTGCGTCGTACAATCCAAGACCACATCGAAGATGCCATTACAGACTTCTACCTTAAAAATCCAAATGAAAAAGATCTC
AAGGCTGTAATGACTTCAAAGGGACACATCACCATTAAATCTGCTAAAAAAACTGAAAAAACTTCTCAGAAAACTGAAGC
ATTAAAAGAAGTCAACTAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(644-717)

ATPase family associated with various cellular activities (AAA) (AAA)

(150-269)

AAA lid domain (AAA_lid_9)

(288-386)

AAA domain (Cdc48 subfamily) (AAA_2)

(473-636)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

84.421

99.867

0.843
  clpE Streptococcus pneumoniae Rx1

82.181

100

0.822
  clpE Streptococcus pneumoniae D39

82.181

100

0.822
  clpE Streptococcus pneumoniae R6

82.181

100

0.822
  clpE Streptococcus pneumoniae TIGR4

82.048

100

0.82
  clpC Lactococcus lactis subsp. cremoris KW2

76.502

99.601

0.762
  clpC Bacillus subtilis subsp. subtilis str. 168

51.772

86.303

0.447
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.189

87.234

0.403
  clpC Streptococcus pneumoniae Rx1

46.984

83.777

0.394
  clpC Streptococcus pneumoniae D39

46.984

83.777

0.394
  clpC Streptococcus pneumoniae TIGR4

46.825

83.777

0.392
  clpC Streptococcus mutans UA159

46.326

83.245

0.386
  clpC Streptococcus thermophilus LMD-9

46.4

83.112

0.386
  clpC Streptococcus thermophilus LMG 18311

46.08

83.112

0.383

Multiple sequence alignment