Detailed information
Bioinformatically predicted
Overview
| Name | sepM | Type | Regulator |
| Locus tag | H1W92_RS07760 | Genome accession | NZ_LR822039 |
| Coordinates | 1475317..1476393 (-) | Length | 358 a.a. |
| NCBI ID | WP_011226464.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus isolate STH_CIRM_1116 | ||
| Function | processing of CSP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1454387..1537517 | 1475317..1476393 | within | 0 |
Gene organization within MGE regions
Location: 1454387..1537517
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H1W92_RS07655 (STHERMO_1668) | gatA | 1455653..1457119 (-) | 1467 | WP_002946584.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA | - |
| H1W92_RS07660 (STHERMO_1669) | gatC | 1457119..1457421 (-) | 303 | WP_002884769.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC | - |
| H1W92_RS07665 (STHERMO_1670) | - | 1457561..1457815 (-) | 255 | WP_011226449.1 | glycosyl transferase | - |
| H1W92_RS07670 (STHERMO_1671) | - | 1457828..1458037 (-) | 210 | WP_011226450.1 | glycosyltransferase | - |
| H1W92_RS07675 | - | 1458353..1459794 (-) | 1442 | Protein_1452 | 6-phospho-beta-glucosidase | - |
| H1W92_RS07680 (STHERMO_1674) | msrA | 1459947..1460456 (-) | 510 | WP_002946589.1 | peptide-methionine (S)-S-oxide reductase MsrA | - |
| H1W92_RS07685 (STHERMO_1675) | - | 1460468..1461316 (-) | 849 | WP_041828318.1 | MetQ/NlpA family ABC transporter substrate-binding protein | - |
| H1W92_RS07690 (STHERMO_1676) | - | 1461439..1461990 (-) | 552 | WP_002946999.1 | cysteine hydrolase family protein | - |
| H1W92_RS07695 (STHERMO_1677) | codY | 1462053..1462838 (-) | 786 | WP_002951720.1 | GTP-sensing pleiotropic transcriptional regulator CodY | - |
| H1W92_RS07700 (STHERMO_1678) | - | 1463098..1464312 (-) | 1215 | WP_011226456.1 | pyridoxal phosphate-dependent aminotransferase | - |
| H1W92_RS07705 (STHERMO_1679) | - | 1464693..1465145 (+) | 453 | WP_002946987.1 | universal stress protein | - |
| H1W92_RS07710 | - | 1465325..1465896 (+) | 572 | Protein_1459 | IS30 family transposase | - |
| H1W92_RS07715 (STHERMO_1683) | - | 1466112..1466582 (-) | 471 | WP_011227497.1 | membrane protein | - |
| H1W92_RS07720 (STHERMO_1685) | pflA | 1466788..1467588 (-) | 801 | WP_002946980.1 | pyruvate formate-lyase-activating protein | - |
| H1W92_RS07725 | - | 1467776..1467886 (-) | 111 | WP_014621906.1 | LPXTG cell wall anchor domain-containing protein | - |
| H1W92_RS07730 (STHERMO_1687) | - | 1468584..1469915 (-) | 1332 | WP_002951727.1 | hemolysin family protein | - |
| H1W92_RS07735 (STHERMO_1688) | - | 1470028..1470810 (+) | 783 | WP_011226459.1 | ABC transporter ATP-binding protein | - |
| H1W92_RS07740 (STHERMO_1690) | - | 1471429..1473495 (-) | 2067 | WP_011227498.1 | cation:proton antiporter | - |
| H1W92_RS07745 (STHERMO_1691) | - | 1473504..1473746 (-) | 243 | WP_011227499.1 | hypothetical protein | - |
| H1W92_RS07750 (STHERMO_1692) | - | 1473743..1474291 (-) | 549 | WP_004197152.1 | tRNA (mnm(5)s(2)U34)-methyltransferase | - |
| H1W92_RS07755 (STHERMO_1693) | - | 1474288..1475232 (-) | 945 | WP_011226463.1 | TIGR01212 family radical SAM protein | - |
| H1W92_RS07760 (STHERMO_1694) | sepM | 1475317..1476393 (-) | 1077 | WP_011226464.1 | SepM family pheromone-processing serine protease | Regulator |
| H1W92_RS07765 (STHERMO_1695) | coaD | 1476371..1476868 (-) | 498 | WP_011226465.1 | pantetheine-phosphate adenylyltransferase | - |
| H1W92_RS07770 (STHERMO_1696) | rsmD | 1476902..1477501 (-) | 600 | WP_011227500.1 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| H1W92_RS07775 (STHERMO_1697) | trxB | 1477592..1478545 (-) | 954 | WP_255136104.1 | thioredoxin-disulfide reductase | - |
| H1W92_RS07780 (STHERMO_1698) | - | 1478578..1478802 (-) | 225 | WP_011226468.1 | DUF4059 family protein | - |
| H1W92_RS07785 (STHERMO_1699) | - | 1479017..1479760 (-) | 744 | WP_011226469.1 | amino acid ABC transporter ATP-binding protein | - |
| H1W92_RS07790 (STHERMO_1700) | - | 1479760..1480506 (-) | 747 | WP_095559509.1 | amino acid ABC transporter permease | - |
| H1W92_RS07795 (STHERMO_1701) | - | 1480895..1481722 (-) | 828 | WP_041827091.1 | transporter substrate-binding domain-containing protein | - |
| H1W92_RS07800 (STHERMO_1702) | - | 1482303..1482536 (-) | 234 | WP_002947030.1 | hypothetical protein | - |
| H1W92_RS07805 (STHERMO_1703) | dinB | 1482822..1483925 (-) | 1104 | WP_011227504.1 | DNA polymerase IV | - |
| H1W92_RS07810 (STHERMO_1704) | pflB | 1484203..1486512 (+) | 2310 | WP_011226473.1 | formate C-acetyltransferase | - |
| H1W92_RS07815 (STHERMO_1705) | - | 1486779..1487561 (+) | 783 | Protein_1480 | carbonic anhydrase | - |
| H1W92_RS07820 | - | 1487612..1488065 (+) | 454 | Protein_1481 | GNAT family N-acetyltransferase | - |
| H1W92_RS07825 (STHERMO_1708) | - | 1488399..1488722 (-) | 324 | WP_011227507.1 | restriction endonuclease subunit S | - |
| H1W92_RS10240 | mobV | 1488747..1489255 (-) | 509 | Protein_1483 | MobV family relaxase | - |
| H1W92_RS07835 (STHERMO_1713) | - | 1489735..1490329 (-) | 595 | Protein_1484 | site-specific integrase | - |
| H1W92_RS07840 (STHERMO_1714) | - | 1490417..1491103 (-) | 687 | WP_011227510.1 | hypothetical protein | - |
| H1W92_RS07845 (STHERMO_1715) | - | 1491179..1491934 (-) | 756 | WP_002951770.1 | ABC transporter permease | - |
| H1W92_RS07850 (STHERMO_1716) | - | 1491931..1492581 (-) | 651 | WP_022096490.1 | ATP-binding cassette domain-containing protein | - |
| H1W92_RS07855 (STHERMO_1718) | - | 1492783..1493739 (-) | 957 | WP_002951776.1 | serine hydrolase domain-containing protein | - |
| H1W92_RS07860 (STHERMO_1719) | - | 1493739..1494494 (-) | 756 | WP_011681560.1 | CppA family protein | - |
| H1W92_RS07865 (STHERMO_1720) | - | 1494847..1495800 (+) | 954 | WP_041826943.1 | IS30 family transposase | - |
| H1W92_RS07870 (STHERMO_1721) | - | 1496021..1496296 (+) | 276 | WP_224103608.1 | CPBP family intramembrane glutamic endopeptidase | - |
| H1W92_RS07875 (STHERMO_1722) | gla | 1496470..1497333 (-) | 864 | WP_002951781.1 | aquaglyceroporin Gla | - |
| H1W92_RS07880 (STHERMO_1723) | - | 1497454..1499721 (+) | 2268 | WP_011227515.1 | Xaa-Pro dipeptidyl-peptidase | - |
| H1W92_RS07885 | - | 1500164..1501554 (+) | 1391 | Protein_1494 | IS3-like element ISSth1b family transposase | - |
| H1W92_RS07890 (STHERMO_1727) | - | 1501700..1501942 (-) | 243 | WP_011227518.1 | Blp family class II bacteriocin | - |
| H1W92_RS07895 (STHERMO_1728) | - | 1502192..1502923 (+) | 732 | WP_002948869.1 | LytR/AlgR family response regulator transcription factor | - |
| H1W92_RS09955 | - | 1503460..1504263 (+) | 804 | WP_224103634.1 | ATP-binding protein | - |
| H1W92_RS07905 (STHERMO_1730) | - | 1504281..1504442 (-) | 162 | WP_011226496.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| H1W92_RS07910 | - | 1504457..1505825 (-) | 1369 | Protein_1499 | bacteriocin secretion accessory protein | - |
| H1W92_RS07915 (STHERMO_1735) | comA/nlmT | 1505841..1507994 (-) | 2154 | WP_059257386.1 | peptide cleavage/export ABC transporter | Regulator |
| H1W92_RS07920 (STHERMO_1738) | - | 1509008..1510753 (-) | 1746 | WP_011226501.1 | ABC transporter ATP-binding protein | - |
| H1W92_RS07925 (STHERMO_1739) | - | 1510746..1512503 (-) | 1758 | WP_011226502.1 | ABC transporter ATP-binding protein | - |
| H1W92_RS09960 (STHERMO_1741) | - | 1512691..1512897 (-) | 207 | WP_002948879.1 | hypothetical protein | - |
| H1W92_RS07935 (STHERMO_1742) | - | 1513102..1513629 (-) | 528 | WP_011227521.1 | VanZ family protein | - |
| H1W92_RS07940 (STHERMO_1743) | rlmN | 1513631..1514800 (-) | 1170 | WP_011227522.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| H1W92_RS07945 (STHERMO_1744) | - | 1514804..1515526 (-) | 723 | WP_011226505.1 | YutD family protein | - |
| H1W92_RS07950 (STHERMO_1745) | - | 1515581..1516936 (-) | 1356 | WP_059257451.1 | bifunctional metallophosphatase/5'-nucleotidase | - |
| H1W92_RS07955 (STHERMO_1748) | - | 1517784..1519127 (-) | 1344 | WP_002948888.1 | DEAD/DEAH box helicase | - |
| H1W92_RS07960 (STHERMO_1749) | mraY | 1519202..1520224 (-) | 1023 | WP_011227524.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| H1W92_RS07965 (STHERMO_1750) | pbp2X | 1520226..1522493 (-) | 2268 | WP_011226508.1 | penicillin-binding protein PBP2X | - |
| H1W92_RS07970 (STHERMO_1751) | ftsL | 1522497..1522817 (-) | 321 | WP_011226509.1 | cell division protein FtsL | - |
| H1W92_RS07975 (STHERMO_1752) | rsmH | 1522820..1523770 (-) | 951 | WP_002888254.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| H1W92_RS07980 (STHERMO_1753) | - | 1523937..1524287 (-) | 351 | WP_011227526.1 | hypothetical protein | - |
| H1W92_RS07985 (STHERMO_1754) | - | 1524384..1524587 (-) | 204 | WP_232086119.1 | hypothetical protein | - |
| H1W92_RS09965 (STHERMO_1756) | - | 1524719..1524931 (-) | 213 | WP_232086120.1 | hypothetical protein | - |
| H1W92_RS07995 (STHERMO_1758) | - | 1525042..1525296 (-) | 255 | WP_011227529.1 | Wzz/FepE/Etk N-terminal domain-containing protein | - |
| H1W92_RS08000 (STHERMO_1759) | - | 1525570..1525926 (-) | 357 | WP_011226513.1 | DUF805 domain-containing protein | - |
| H1W92_RS08005 (STHERMO_1760) | - | 1526146..1526442 (-) | 297 | WP_231108735.1 | hypothetical protein | - |
| H1W92_RS08010 (STHERMO_1761) | - | 1526796..1528046 (-) | 1251 | WP_011226515.1 | glutamate-5-semialdehyde dehydrogenase | - |
| H1W92_RS08015 (STHERMO_1762) | proB | 1528048..1528851 (-) | 804 | WP_002948808.1 | glutamate 5-kinase | - |
| H1W92_RS08020 (STHERMO_1763) | - | 1528972..1530561 (-) | 1590 | WP_180475752.1 | ABC transporter permease | - |
| H1W92_RS08025 (STHERMO_1764) | - | 1530564..1531296 (-) | 733 | Protein_1522 | ABC transporter ATP-binding protein | - |
| H1W92_RS08030 (STHERMO_1767) | - | 1531570..1532303 (+) | 734 | Protein_1523 | DUF554 domain-containing protein | - |
| H1W92_RS08035 (STHERMO_1768) | addA | 1532697..1536350 (-) | 3654 | WP_011227531.1 | helicase-exonuclease AddAB subunit AddA | - |
Sequence
Protein
Download Length: 358 a.a. Molecular weight: 39232.11 Da Isoelectric Point: 9.4944
>NTDB_id=1131958 H1W92_RS07760 WP_011226464.1 1475317..1476393(-) (sepM) [Streptococcus thermophilus isolate STH_CIRM_1116]
MANKTKSKSLLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYTQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGKTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
MANKTKSKSLLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYTQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGKTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
Nucleotide
Download Length: 1077 bp
>NTDB_id=1131958 H1W92_RS07760 WP_011226464.1 1475317..1476393(-) (sepM) [Streptococcus thermophilus isolate STH_CIRM_1116]
GTGGCAAACAAGACAAAATCTAAATCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATACTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAAGACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
GTGGCAAACAAGACAAAATCTAAATCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATACTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAAGACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sepM | Streptococcus mutans UA159 |
62.757 |
95.251 |
0.598 |