Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   H1W87_RS01625 Genome accession   NZ_LR822037
Coordinates   294739..296256 (+) Length   505 a.a.
NCBI ID   WP_179966916.1    Uniprot ID   A0A2H4K9K7
Organism   Streptococcus thermophilus isolate STH_CIRM_1121     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 289739..301256
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W87_RS09460 - 290019..290189 (+) 171 Protein_262 ascorbate 6-phosphate lactonase -
  H1W87_RS01600 (STHERMO_0329) - 290206..290877 (-) 672 WP_002946492.1 potassium channel family protein -
  H1W87_RS01605 (STHERMO_0330) - 290917..292281 (-) 1365 WP_084829346.1 TrkH family potassium uptake protein -
  H1W87_RS01610 (STHERMO_0331) rsmG 292351..293064 (-) 714 WP_180478394.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  H1W87_RS01615 (STHERMO_0332) - 293361..293897 (+) 537 WP_002946488.1 DUF177 domain-containing protein -
  H1W87_RS01620 (STHERMO_0333) covR 294053..294742 (+) 690 WP_002949638.1 response regulator transcription factor Regulator
  H1W87_RS01625 (STHERMO_0334) covS 294739..296256 (+) 1518 WP_179966916.1 HAMP domain-containing histidine kinase Regulator
  H1W87_RS01630 (STHERMO_0335) nrdR 296378..296857 (+) 480 WP_002949642.1 transcriptional regulator NrdR -
  H1W87_RS01635 (STHERMO_0336) - 296854..298029 (+) 1176 WP_002949643.1 DnaD domain protein -
  H1W87_RS01640 (STHERMO_0337) dnaI 298033..298935 (+) 903 WP_002946786.1 primosomal protein DnaI -
  H1W87_RS01645 (STHERMO_0338) der 299041..300351 (+) 1311 WP_180478396.1 ribosome biogenesis GTPase Der -
  H1W87_RS01650 - 300415..301084 (+) 670 Protein_273 HI_0552 family protein -

Sequence

Protein


Download         Length: 505 a.a.        Molecular weight: 57564.94 Da        Isoelectric Point: 5.2689

>NTDB_id=1131871 H1W87_RS01625 WP_179966916.1 294739..296256(+) (covS) [Streptococcus thermophilus isolate STH_CIRM_1121]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSVYVYDKKGTFIFTSEEDTDSPPGMSEVNKLRLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide


Download         Length: 1518 bp        

>NTDB_id=1131871 H1W87_RS01625 WP_179966916.1 294739..296256(+) (covS) [Streptococcus thermophilus isolate STH_CIRM_1121]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTGTCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAGGTTAGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCATTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(384-494)

ArlS sensor domain (ArlS_N)

(39-187)

His Kinase A (phospho-acceptor) domain (HisKA)

(270-329)

HAMP domain (HAMP)

(213-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2H4K9K7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Streptococcus salivarius strain HSISS4

94.422

99.406

0.939

Multiple sequence alignment