Detailed information NTG1131811

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: H1W84_RS01705
• Genome accession: NZ_LR822036
• Coordinates: 309403..310920 (+)
• Length: 505 a.a.
• NCBI ID: WP_014607970.1
• Uniprot ID: A0A2H4K9K6
• Organism: Streptococcus thermophilus isolate STH_CIRM_1055
• Function: repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 304403..315920

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H1W84_RS09815	-	304683..304853 (+)	171	Protein_278	ascorbate 6-phosphate lactonase	-
H1W84_RS01680 (STHERMO_0339)	-	304870..305541 (-)	672	WP_002946492.1	potassium channel family protein	-
H1W84_RS01685 (STHERMO_0340)	-	305581..306945 (-)	1365	WP_014607967.1	TrkH family potassium uptake protein	-
H1W84_RS01690 (STHERMO_0341)	rsmG	307015..307728 (-)	714	WP_002946490.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
H1W84_RS01695 (STHERMO_0342)	-	308025..308561 (+)	537	WP_014607968.1	DUF177 domain-containing protein	-
H1W84_RS01700 (STHERMO_0343)	covR	308717..309406 (+)	690	WP_014607969.1	response regulator transcription factor	Regulator
H1W84_RS01705 (STHERMO_0344)	covS	309403..310920 (+)	1518	WP_014607970.1	HAMP domain-containing histidine kinase	Regulator
H1W84_RS01710 (STHERMO_0345)	nrdR	311042..311521 (+)	480	WP_011680738.1	transcriptional regulator NrdR	-
H1W84_RS01715 (STHERMO_0346)	-	311518..312693 (+)	1176	WP_011680739.1	DnaD domain protein	-
H1W84_RS01720 (STHERMO_0347)	dnaI	312697..313599 (+)	903	WP_014607971.1	primosomal protein DnaI	-
H1W84_RS01725 (STHERMO_0348)	der	313705..315015 (+)	1311	WP_014607972.1	ribosome biogenesis GTPase Der	-
H1W84_RS10290	-	315079..315738 (+)	660	Protein_289	HI_0552 family protein	-

Sequence

Protein

• Length: 505 a.a.
• Molecular weight: 57550.96 Da
• Isoelectric Point: 5.2689

>NTDB_id=1131811 H1W84_RS01705 WP_014607970.1 309403..310920(+) (covS) [Streptococcus thermophilus isolate STH_CIRM_1055]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSIYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide

• Length: 1518 bp

>NTDB_id=1131811 H1W84_RS01705 WP_014607970.1 309403..310920(+) (covS) [Streptococcus thermophilus isolate STH_CIRM_1055]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTATCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (384-494)

• ArlS sensor domain (ArlS_N) (39-187)

• His Kinase A (phospho-acceptor) domain (HisKA) (270-329)

• HAMP domain (HAMP) (213-265)

3D structure

• AlphaFold DB: A0A2H4K9K6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Streptococcus salivarius strain HSISS4	94.422	99.406	0.939