Detailed information
Bioinformatically predicted
Overview
| Name | sepM | Type | Regulator |
| Locus tag | H1W91_RS07895 | Genome accession | NZ_LR822032 |
| Coordinates | 1511983..1513059 (-) | Length | 358 a.a. |
| NCBI ID | WP_180477137.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus isolate STH_CIRM_1050 | ||
| Function | processing of CSP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1497240..1570869 | 1511983..1513059 | within | 0 |
Gene organization within MGE regions
Location: 1497240..1570869
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H1W91_RS07825 (STHERMO_1710) | - | 1498130..1498681 (-) | 552 | WP_173940634.1 | cysteine hydrolase family protein | - |
| H1W91_RS07830 (STHERMO_1711) | codY | 1498744..1499529 (-) | 786 | WP_002951720.1 | GTP-sensing pleiotropic transcriptional regulator CodY | - |
| H1W91_RS07835 (STHERMO_1712) | - | 1499789..1501003 (-) | 1215 | WP_180477135.1 | pyridoxal phosphate-dependent aminotransferase | - |
| H1W91_RS07840 (STHERMO_1713) | - | 1501358..1501810 (+) | 453 | WP_180477136.1 | universal stress protein | - |
| H1W91_RS10140 | - | 1501990..1502561 (+) | 572 | Protein_1492 | IS30 family transposase | - |
| H1W91_RS07845 (STHERMO_1716) | - | 1502633..1502806 (-) | 174 | WP_011681546.1 | hypothetical protein | - |
| H1W91_RS07850 (STHERMO_1717) | - | 1502867..1503241 (-) | 375 | WP_011681547.1 | membrane protein | - |
| H1W91_RS07855 (STHERMO_1718) | pflA | 1503453..1504253 (-) | 801 | WP_002946980.1 | pyruvate formate-lyase-activating protein | - |
| H1W91_RS07860 | - | 1504441..1504551 (-) | 111 | WP_014621906.1 | LPXTG cell wall anchor domain-containing protein | - |
| H1W91_RS07865 (STHERMO_1720) | - | 1505249..1506580 (-) | 1332 | WP_002951727.1 | hemolysin family protein | - |
| H1W91_RS07870 (STHERMO_1721) | - | 1506694..1507476 (+) | 783 | WP_011226459.1 | ABC transporter ATP-binding protein | - |
| H1W91_RS10545 (STHERMO_1722) | - | 1507811..1508045 (+) | 235 | Protein_1499 | hypothetical protein | - |
| H1W91_RS07875 (STHERMO_1723) | - | 1508095..1510161 (-) | 2067 | WP_011226460.1 | cation:proton antiporter | - |
| H1W91_RS07880 (STHERMO_1724) | - | 1510170..1510412 (-) | 243 | WP_011226461.1 | hypothetical protein | - |
| H1W91_RS07885 (STHERMO_1725) | - | 1510409..1510957 (-) | 549 | WP_011226462.1 | tRNA (mnm(5)s(2)U34)-methyltransferase | - |
| H1W91_RS07890 (STHERMO_1726) | - | 1510954..1511898 (-) | 945 | WP_011226463.1 | TIGR01212 family radical SAM protein | - |
| H1W91_RS07895 (STHERMO_1727) | sepM | 1511983..1513059 (-) | 1077 | WP_180477137.1 | SepM family pheromone-processing serine protease | Regulator |
| H1W91_RS07900 (STHERMO_1728) | coaD | 1513037..1513534 (-) | 498 | WP_164178277.1 | pantetheine-phosphate adenylyltransferase | - |
| H1W91_RS07905 (STHERMO_1729) | rsmD | 1513568..1514167 (-) | 600 | Protein_1506 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| H1W91_RS07910 (STHERMO_1730) | trxB | 1514258..1515211 (-) | 954 | WP_255136104.1 | thioredoxin-disulfide reductase | - |
| H1W91_RS07915 (STHERMO_1731) | - | 1515244..1515468 (-) | 225 | WP_002951743.1 | DUF4059 family protein | - |
| H1W91_RS07920 (STHERMO_1732) | - | 1515683..1516426 (-) | 744 | WP_164178279.1 | amino acid ABC transporter ATP-binding protein | - |
| H1W91_RS07925 (STHERMO_1733) | - | 1516426..1517172 (-) | 747 | WP_095559509.1 | amino acid ABC transporter permease | - |
| H1W91_RS07930 (STHERMO_1734) | - | 1517566..1518396 (-) | 831 | WP_180477138.1 | transporter substrate-binding domain-containing protein | - |
| H1W91_RS07935 (STHERMO_1735) | - | 1518967..1519200 (-) | 234 | WP_002947030.1 | hypothetical protein | - |
| H1W91_RS07940 (STHERMO_1736) | dinB | 1519498..1520601 (-) | 1104 | WP_014608654.1 | DNA polymerase IV | - |
| H1W91_RS07945 (STHERMO_1737) | pflB | 1520880..1523189 (+) | 2310 | WP_180477139.1 | formate C-acetyltransferase | - |
| H1W91_RS07950 | - | 1523456..1524238 (+) | 783 | Protein_1515 | carbonic anhydrase | - |
| H1W91_RS07955 (STHERMO_1740) | - | 1524289..1524741 (+) | 453 | WP_176243562.1 | GNAT family N-acetyltransferase | - |
| H1W91_RS07960 (STHERMO_1741) | - | 1525075..1525377 (-) | 303 | WP_232087099.1 | restriction endonuclease subunit S | - |
| H1W91_RS10440 | mobV | 1525423..1525930 (-) | 508 | Protein_1518 | MobV family relaxase | - |
| H1W91_RS07975 | - | 1526416..1527004 (-) | 589 | Protein_1519 | site-specific integrase | - |
| H1W91_RS07980 (STHERMO_1745) | - | 1527092..1527775 (-) | 684 | WP_232087100.1 | YdcF family protein | - |
| H1W91_RS07985 (STHERMO_1746) | - | 1527855..1528610 (-) | 756 | WP_180477142.1 | ABC transporter permease | - |
| H1W91_RS07990 (STHERMO_1747) | - | 1528607..1529257 (-) | 651 | WP_180477143.1 | ATP-binding cassette domain-containing protein | - |
| H1W91_RS07995 (STHERMO_1749) | - | 1529460..1530416 (-) | 957 | WP_180477144.1 | serine hydrolase domain-containing protein | - |
| H1W91_RS08000 (STHERMO_1750) | - | 1530416..1531171 (-) | 756 | WP_180477145.1 | CppA family protein | - |
| H1W91_RS08005 | - | 1531453..1531728 (+) | 276 | WP_232087101.1 | CPBP family intramembrane glutamic endopeptidase | - |
| H1W91_RS08010 (STHERMO_1752) | gla | 1531902..1532765 (-) | 864 | WP_173940640.1 | aquaglyceroporin Gla | - |
| H1W91_RS08015 (STHERMO_1753) | - | 1532886..1535153 (+) | 2268 | WP_180477146.1 | Xaa-Pro dipeptidyl-peptidase | - |
| H1W91_RS08020 (STHERMO_1754) | - | 1535233..1535613 (-) | 381 | WP_002951783.1 | hypothetical protein | - |
| H1W91_RS08025 | - | 1535738..1536001 (-) | 264 | WP_002945924.1 | hypothetical protein | - |
| H1W91_RS08030 (STHERMO_1757) | - | 1536323..1536619 (-) | 297 | WP_004197070.1 | bacteriocin immunity protein | - |
| H1W91_RS08035 (STHERMO_1758) | - | 1536784..1536966 (-) | 183 | WP_179973975.1 | hypothetical protein | - |
| H1W91_RS08040 (STHERMO_1759) | - | 1537021..1537713 (-) | 693 | WP_224103184.1 | thioredoxin family protein | - |
| H1W91_RS08045 | - | 1537904..1539474 (+) | 1571 | WP_087009847.1 | IS3-like element ISSth1b family transposase | - |
| H1W91_RS08050 (STHERMO_1762) | - | 1539620..1539886 (-) | 267 | WP_180477147.1 | Blp family class II bacteriocin | - |
| H1W91_RS10445 (STHERMO_1763) | - | 1540137..1540538 (-) | 402 | WP_311316656.1 | hypothetical protein | - |
| H1W91_RS08055 (STHERMO_1767) | - | 1541525..1541755 (-) | 231 | WP_011226494.1 | bacteriocin class II family protein | - |
| H1W91_RS08060 (STHERMO_1768) | - | 1542005..1542736 (+) | 732 | WP_180477148.1 | LytR/AlgR family response regulator transcription factor | - |
| H1W91_RS10150 | - | 1543273..1544076 (+) | 804 | WP_224103634.1 | ATP-binding protein | - |
| H1W91_RS08070 (STHERMO_1770) | - | 1544094..1544255 (-) | 162 | WP_011226496.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| H1W91_RS08075 (STHERMO_1771) | - | 1544270..1545637 (-) | 1368 | WP_180477149.1 | bacteriocin secretion accessory protein | - |
| H1W91_RS08080 | - | 1545653..1547806 (-) | 2154 | Protein_1541 | peptide cleavage/export ABC transporter | - |
| H1W91_RS08085 (STHERMO_1777) | - | 1548820..1550565 (-) | 1746 | WP_180477150.1 | ABC transporter ATP-binding protein | - |
| H1W91_RS08090 (STHERMO_1778) | - | 1550558..1552315 (-) | 1758 | WP_180477151.1 | ABC transporter ATP-binding protein | - |
| H1W91_RS10155 (STHERMO_1780) | - | 1552503..1552709 (-) | 207 | WP_232087102.1 | hypothetical protein | - |
| H1W91_RS08100 (STHERMO_1782) | - | 1552914..1553441 (-) | 528 | WP_180477152.1 | VanZ family protein | - |
| H1W91_RS08105 (STHERMO_1783) | rlmN | 1553443..1554612 (-) | 1170 | WP_011226504.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| H1W91_RS08110 (STHERMO_1784) | - | 1554616..1555338 (-) | 723 | WP_014621927.1 | YutD family protein | - |
| H1W91_RS08115 (STHERMO_1785) | - | 1555393..1556748 (-) | 1356 | WP_002948886.1 | bifunctional metallophosphatase/5'-nucleotidase | - |
| H1W91_RS08120 (STHERMO_1788) | - | 1557596..1558939 (-) | 1344 | WP_002948888.1 | DEAD/DEAH box helicase | - |
| H1W91_RS08125 (STHERMO_1789) | mraY | 1559014..1560036 (-) | 1023 | WP_011227524.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| H1W91_RS08130 (STHERMO_1790) | pbp2X | 1560038..1562305 (-) | 2268 | WP_180477153.1 | penicillin-binding protein PBP2X | - |
| H1W91_RS08135 (STHERMO_1791) | ftsL | 1562309..1562629 (-) | 321 | WP_014608671.1 | cell division protein FtsL | - |
| H1W91_RS08140 (STHERMO_1792) | rsmH | 1562632..1563582 (-) | 951 | WP_002888254.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| H1W91_RS08145 (STHERMO_1793) | - | 1563748..1564281 (-) | 534 | WP_232087103.1 | hypothetical protein | - |
| H1W91_RS08150 (STHERMO_1794) | - | 1564288..1564740 (-) | 453 | WP_232087104.1 | hypothetical protein | - |
| H1W91_RS08155 (STHERMO_1796) | - | 1564823..1565071 (+) | 249 | WP_002951833.1 | hypothetical protein | - |
| H1W91_RS08160 (STHERMO_1798) | - | 1565377..1565733 (-) | 357 | Protein_1557 | DUF805 domain-containing protein | - |
| H1W91_RS08165 (STHERMO_1800) | - | 1565952..1566242 (-) | 291 | WP_232087105.1 | hypothetical protein | - |
| H1W91_RS08170 (STHERMO_1801) | - | 1566576..1567826 (-) | 1251 | WP_065972556.1 | glutamate-5-semialdehyde dehydrogenase | - |
| H1W91_RS08175 (STHERMO_1802) | proB | 1567828..1568631 (-) | 804 | WP_002948808.1 | glutamate 5-kinase | - |
| H1W91_RS08180 (STHERMO_1803) | - | 1568752..1570341 (-) | 1590 | WP_180477154.1 | DUF4231 domain-containing protein | - |
Sequence
Protein
Download Length: 358 a.a. Molecular weight: 39216.11 Da Isoelectric Point: 9.4944
>NTDB_id=1131601 H1W91_RS07895 WP_180477137.1 1511983..1513059(-) (sepM) [Streptococcus thermophilus isolate STH_CIRM_1050]
MANKTKSKSLLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGILN
IADTVTAVNGKTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
MANKTKSKSLLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGILN
IADTVTAVNGKTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
Nucleotide
Download Length: 1077 bp
>NTDB_id=1131601 H1W91_RS07895 WP_180477137.1 1511983..1513059(-) (sepM) [Streptococcus thermophilus isolate STH_CIRM_1050]
GTGGCAAACAAGACAAAATCTAAATCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTATCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAAGACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
GTGGCAAACAAGACAAAATCTAAATCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTATCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAAGACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sepM | Streptococcus mutans UA159 |
62.757 |
95.251 |
0.598 |