Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   H1W89_RS06535 Genome accession   NZ_LR822029
Coordinates   1244277..1246535 (+) Length   752 a.a.
NCBI ID   WP_180474585.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_1035     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 1239277..1251535
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W89_RS06510 (STHERMO_1433) - 1240424..1240900 (-) 477 WP_180474583.1 ferrous iron transport protein A -
  H1W89_RS06515 (STHERMO_1434) - 1241074..1241808 (-) 735 WP_180474584.1 amino acid ABC transporter ATP-binding protein -
  H1W89_RS06520 (STHERMO_1435) - 1241808..1242488 (-) 681 WP_014608117.1 amino acid ABC transporter permease -
  H1W89_RS06525 (STHERMO_1436) - 1242757..1242987 (-) 231 WP_011225686.1 DUF1797 family protein -
  H1W89_RS06530 (STHERMO_1437) argF 1243056..1244036 (-) 981 WP_084828593.1 ornithine carbamoyltransferase -
  H1W89_RS06535 (STHERMO_1438) clpE 1244277..1246535 (+) 2259 WP_180474585.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  H1W89_RS06540 (STHERMO_1439) - 1246678..1247136 (+) 459 WP_002947302.1 NUDIX hydrolase -
  H1W89_RS06545 (STHERMO_1440) - 1247146..1247448 (+) 303 WP_180474586.1 DUF1827 family protein -
  H1W89_RS06550 - 1247489..1248452 (-) 964 Protein_1245 Gfo/Idh/MocA family protein -
  H1W89_RS06555 (STHERMO_1444) - 1248551..1249786 (-) 1236 WP_014608114.1 aminoacyltransferase -
  H1W89_RS06560 (STHERMO_1445) - 1249882..1250307 (-) 426 WP_002950186.1 VTT domain-containing protein -
  H1W89_RS09940 (STHERMO_1446) - 1250519..1250785 (-) 267 WP_080998415.1 DUF3862 domain-containing protein -
  H1W89_RS09945 (STHERMO_1447) - 1250743..1251141 (-) 399 WP_014608112.1 DUF3862 domain-containing protein -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83825.09 Da        Isoelectric Point: 5.4282

>NTDB_id=1131413 H1W89_RS06535 WP_180474585.1 1244277..1246535(+) (clpE) [Streptococcus thermophilus isolate STH_CIRM_1035]
MLCQNCNLNEASIHLYTNVNGNQQQVDLCQHCYKIIKSDPENPLNQFNQAGGSNFFDDFFSDLNNFRSSNGDLPNTPPTQ
EGGNRGNGGPGRPGGPRQQAPQQPQGLLEEFGINITDIARRGDIDPVIGRDEEIIRVIEILNRRTKNNPVLIGEPGVGKT
AVVEGLAQKIVDGDVPQKLQSKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVGAGNTGDGNM
DAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILRGIQPKYQDYHHVKYTDEAITAAA
ELSNRYIQDRFLPDKAIDLLDESGSKMNLTLNFIDPKDLDKRLIEAENLKAQATRDEDFEKAAYFRDQIAKYKEMQQQTI
KDQDMPIITEKHIEAIVEQKTNIPIGDLKEKEQSQLLNLADDLKAHVIGQDAAVDKIAKAIRRNRVGLGAPNRPIGSFLF
VGPTGVGKTELSKQLAIELFGSSDSMIRFDMSEYMEKHAVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDEVEKAH
PDVLHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAARENRTNSVINHLGDFFSPEFMNRFDGIIE
FSALSKKNLLTIVDLMLDGVNQRLANNGIHLSVADKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLKNPNEKDL
KAVMTSKRHITIKSAKKTEKTSQKTEALKEVN

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=1131413 H1W89_RS06535 WP_180474585.1 1244277..1246535(+) (clpE) [Streptococcus thermophilus isolate STH_CIRM_1035]
ATGCTCTGTCAAAACTGTAACCTTAATGAAGCTAGTATCCATTTGTATACCAACGTAAATGGTAATCAGCAACAAGTTGA
CCTCTGTCAACATTGTTATAAAATCATAAAATCTGATCCAGAGAACCCCCTTAACCAATTCAATCAAGCAGGAGGTTCCA
ACTTCTTCGACGATTTCTTCAGTGACCTAAACAACTTCCGTTCTTCTAACGGAGACCTTCCTAATACACCTCCAACACAA
GAGGGAGGTAACCGTGGAAACGGTGGTCCAGGCCGTCCTGGAGGACCACGTCAACAAGCCCCTCAACAACCTCAAGGCCT
TCTCGAAGAATTTGGAATTAATATCACAGATATTGCTCGTCGTGGAGACATTGATCCTGTCATTGGTCGTGACGAAGAAA
TCATTCGCGTCATCGAAATTCTGAACCGCCGTACCAAGAACAATCCTGTTCTTATCGGTGAACCTGGTGTTGGTAAGACC
GCAGTAGTCGAAGGACTTGCCCAAAAAATCGTTGATGGAGATGTGCCACAAAAACTCCAAAGCAAGCAAGTTATCCGTCT
TGATGTTGTAAGCCTAGTTCAAGGGACTGGTATCCGCGGCCAGTTCGAAGAACGCATGCAAAAGCTCATGGAGGAAATCC
GCCAACGTCAGGATGTTATCCTCTTTATTGATGAAATCCATGAAATTGTAGGAGCTGGTAATACTGGGGACGGCAATATG
GATGCTGGAAACATCTTAAAACCTGCACTTGCCCGTGGAGAGCTTCAACTTGTTGGAGCAACAACACTCAACGAATACCG
TATCATTGAGAAAGATGCGGCACTCGAACGTCGTATGCAACCTGTTAAGGTAGATGAGCCAACAGTTGAGGAAACAATCA
CAATTTTGCGTGGTATCCAGCCTAAATATCAAGACTACCACCATGTCAAATACACTGATGAAGCCATTACTGCAGCTGCA
GAATTATCCAACCGCTACATTCAGGACCGTTTCTTGCCAGACAAGGCCATCGACCTTCTCGATGAATCTGGCTCTAAGAT
GAATTTAACCCTCAACTTTATTGATCCTAAGGACCTCGATAAACGTTTGATTGAAGCTGAGAATCTTAAAGCTCAGGCTA
CTCGTGACGAAGACTTTGAAAAAGCTGCTTATTTCCGTGACCAAATTGCTAAATACAAGGAAATGCAACAGCAAACCATC
AAAGACCAAGATATGCCTATCATTACTGAAAAACATATCGAAGCCATTGTCGAGCAAAAAACCAATATTCCTATCGGTGA
TTTAAAAGAAAAAGAACAATCTCAACTTCTCAACCTCGCCGATGACCTTAAGGCGCATGTTATTGGCCAAGATGCCGCAG
TTGATAAGATTGCCAAAGCTATCCGCCGTAATCGTGTTGGACTTGGTGCACCAAACCGCCCAATTGGTAGCTTCCTATTT
GTAGGCCCTACAGGAGTCGGTAAAACTGAGCTCTCTAAACAGTTAGCCATCGAGCTCTTTGGTTCATCTGATAGTATGAT
TCGTTTTGACATGTCAGAATACATGGAAAAACACGCTGTTGCTAAATTGGTCGGTGCTCCTCCAGGCTATGTTGGTTACG
ACGAAGCTGGGCAATTAACCGAAAAGGTCCGCCGTAACCCTTATTCACTCATTCTCCTTGATGAGGTTGAAAAAGCTCAC
CCAGATGTGCTTCACATGTTCCTTCAGGTACTCGACGATGGTCGTCTGACTGATGGTCAAGGGAGAACTGTAAGTTTCAA
AGATACCATCATCATCATGACTTCAAATGCTGGTACTGGTAAAGTGGAAGCAAGTGTAGGTTTTGGAGCTGCTCGTGAGA
ATCGTACCAATTCTGTTATCAACCACCTTGGAGATTTCTTCAGTCCTGAATTCATGAACCGTTTTGACGGTATTATCGAG
TTCTCTGCCCTAAGCAAGAAAAATCTCCTTACTATCGTGGACCTTATGCTTGATGGCGTCAACCAACGCTTGGCAAACAA
CGGTATCCACCTCAGTGTGGCTGATAAAGTTAAGGAAAAACTGGTTGACCTTGGTTATGATCCTAAGATGGGTGCTCGAC
CATTGCGTCGTACAATCCAAGACCACATCGAAGATGCCATTACAGACTTCTACCTTAAAAATCCAAATGAAAAAGATCTC
AAGGCTGTAATGACTTCAAAGAGACACATCACCATTAAATCTGCTAAAAAAACTGAAAAAACTTCTCAGAAAACTGAAGC
ATTAAAAGAAGTCAACTAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(473-636)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(644-717)

ATPase family associated with various cellular activities (AAA) (AAA)

(150-269)

AAA lid domain (AAA_lid_9)

(288-386)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

84.288

99.867

0.842
  clpE Streptococcus pneumoniae Rx1

81.915

100

0.819
  clpE Streptococcus pneumoniae D39

81.915

100

0.819
  clpE Streptococcus pneumoniae R6

81.915

100

0.819
  clpE Streptococcus pneumoniae TIGR4

81.782

100

0.818
  clpC Lactococcus lactis subsp. cremoris KW2

76.235

99.601

0.759
  clpC Bacillus subtilis subsp. subtilis str. 168

52.97

82.846

0.439
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.037

87.234

0.402
  clpC Streptococcus pneumoniae Rx1

46.984

83.777

0.394
  clpC Streptococcus pneumoniae D39

46.984

83.777

0.394
  clpC Streptococcus pneumoniae TIGR4

46.825

83.777

0.392
  clpC Streptococcus thermophilus LMD-9

46.24

83.112

0.384
  clpC Streptococcus mutans UA159

46.166

83.245

0.384
  clpC Streptococcus thermophilus LMG 18311

45.92

83.112

0.382

Multiple sequence alignment