Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   H1X63_RS03245 Genome accession   NZ_LR822027
Coordinates   608128..610386 (-) Length   752 a.a.
NCBI ID   WP_179972782.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_998     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 603128..615386
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1X63_RS03205 (STHERMO_0646) - 603192..603812 (+) 621 WP_014621341.1 DUF3862 domain-containing protein -
  H1X63_RS03210 (STHERMO_0647) - 604076..604567 (+) 492 WP_232086291.1 TVP38/TMEM64 family protein -
  H1X63_RS03215 (STHERMO_0648) - 604545..605780 (+) 1236 WP_179972778.1 aminoacyltransferase -
  H1X63_RS03220 - 605879..606842 (+) 964 Protein_575 Gfo/Idh/MocA family protein -
  H1X63_RS03225 (STHERMO_0651) - 606883..607053 (-) 171 Protein_576 DUF1827 family protein -
  H1X63_RS03230 (STHERMO_0652) - 607049..607219 (-) 171 Protein_577 DUF1827 family protein -
  H1X63_RS03235 (STHERMO_0653) - 607215..607517 (-) 303 WP_179972780.1 DUF1827 family protein -
  H1X63_RS03240 (STHERMO_0654) - 607527..607985 (-) 459 WP_179972781.1 NUDIX hydrolase -
  H1X63_RS03245 (STHERMO_0655) clpE 608128..610386 (-) 2259 WP_179972782.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  H1X63_RS03250 (STHERMO_0656) argF 610627..611607 (+) 981 WP_179972783.1 ornithine carbamoyltransferase -
  H1X63_RS03255 (STHERMO_0657) - 611676..611906 (+) 231 WP_179972784.1 DUF1797 family protein -
  H1X63_RS03260 (STHERMO_0659) - 612174..612854 (+) 681 WP_014608117.1 amino acid ABC transporter permease -
  H1X63_RS03265 (STHERMO_0660) - 612854..613588 (+) 735 WP_179972785.1 amino acid ABC transporter ATP-binding protein -
  H1X63_RS03270 (STHERMO_0661) - 613762..614238 (+) 477 WP_179972786.1 ferrous iron transport protein A -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83854.10 Da        Isoelectric Point: 5.1007

>NTDB_id=1131337 H1X63_RS03245 WP_179972782.1 608128..610386(-) (clpE) [Streptococcus thermophilus isolate STH_CIRM_998]
MLCQNCNLNEASIHLYTNVNGNQQQVDLCQHCYKIMKSDPGNPLNQFNQAGGSNFFDDFFSDLNNFRSSNRDLPNTPPTQ
EGGNRGNGGPGRPGGPRQQAPQQLQGLLEEFGINITDIARRGDIDPVIGRDEEIIRVIEILNRRTKNNPVLIGEPGVGKT
AVVEGLAQKIVDGDVPQKLQSKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVGAGNTGDGNM
DAGNILKPALARGELQLVGATTLDEYRIIEKDAALERRMQPVKVDEPTVEETITILRGIQPKYQDYHHVKYTDEAITAAV
ELSNRYIQDRFLPDKAIDLLDESGSKMNLTLNFIDPKDLDKRLIEAENLKAQATRDEDFEKAAYFRDQIAKYKEMQQQTI
KDQDMPIITEKHIEAIVEQKTNIPVGDLKEKEQSQLLNLADDLKAHVIGQDAAVDKIAKAIRRNRVGLGAPNRPIGSFLF
VGPTGVGKTELSKQLAIELFGSSDSMIRFDMSEYMEKHAVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDEIEKAH
PDVLHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAARENRTNSIINQLGDFFSPEFMNRFDGIIE
FNALSKENLLTIVDLMLDGVNQRLANNGIYLSVTDKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLKNPNEKDL
KAVMTSKGNITIKSAKKTEKTSQKTEALKEAN

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=1131337 H1X63_RS03245 WP_179972782.1 608128..610386(-) (clpE) [Streptococcus thermophilus isolate STH_CIRM_998]
ATGCTCTGCCAAAACTGTAATCTTAATGAAGCTAGTATCCATTTGTATACCAACGTAAATGGTAATCAACAACAAGTTGA
CCTCTGTCAACATTGTTATAAAATCATGAAATCTGATCCAGGGAACCCCCTTAACCAATTCAATCAAGCAGGAGGTTCCA
ACTTCTTCGACGATTTCTTCAGTGACCTAAACAATTTCCGTTCTTCTAACAGAGACCTTCCTAATACACCTCCAACACAA
GAGGGAGGTAACCGTGGAAACGGTGGTCCGGGCCGTCCTGGAGGACCACGTCAACAAGCCCCTCAACAACTTCAAGGCCT
TCTCGAAGAATTCGGAATTAATATCACAGATATTGCTCGTCGTGGAGACATTGATCCTGTCATTGGTCGTGACGAAGAAA
TCATTCGCGTCATCGAAATTCTGAACCGCCGTACCAAGAACAATCCTGTTCTTATCGGTGAACCTGGTGTTGGTAAGACC
GCAGTAGTCGAAGGACTTGCCCAAAAAATTGTTGATGGAGATGTACCACAAAAACTCCAAAGCAAGCAAGTTATCCGTCT
TGATGTTGTAAGCCTAGTTCAAGGGACTGGTATCCGCGGCCAGTTCGAAGAACGCATGCAGAAGCTCATGGAGGAAATCC
GCCAACGTCAGGATGTTATCCTCTTTATTGATGAAATCCATGAAATTGTAGGAGCTGGTAATACTGGGGACGGCAATATG
GATGCTGGAAACATCTTAAAACCTGCACTTGCCCGTGGAGAGCTTCAACTTGTTGGAGCAACAACACTCGACGAATACCG
TATCATTGAGAAAGATGCGGCACTCGAACGTCGTATGCAACCCGTTAAGGTAGATGAGCCAACAGTTGAGGAAACAATCA
CAATTTTGCGTGGGATCCAGCCTAAATATCAAGACTACCACCATGTCAAATACACTGATGAAGCCATTACTGCAGCTGTA
GAATTATCCAACCGCTACATTCAGGACCGTTTCTTGCCAGACAAGGCCATCGACCTTCTCGATGAATCTGGCTCTAAGAT
GAATTTAACCCTCAACTTTATCGATCCTAAGGACCTCGATAAACGTTTAATTGAAGCTGAGAATCTTAAAGCTCAGGCTA
CTCGTGACGAAGACTTTGAAAAAGCTGCTTATTTCCGTGACCAAATTGCTAAATACAAGGAAATGCAACAGCAAACCATC
AAAGACCAAGATATGCCTATCATTACTGAGAAACATATCGAAGCCATTGTCGAGCAAAAAACCAATATTCCTGTCGGTGA
TTTAAAAGAAAAAGAACAATCTCAACTTCTCAACCTCGCCGATGACCTTAAGGCGCATGTTATTGGCCAAGATGCCGCAG
TTGATAAGATTGCTAAAGCTATCCGCCGTAATCGTGTTGGACTCGGTGCACCAAACCGCCCAATTGGTAGCTTCCTATTT
GTGGGTCCTACAGGAGTCGGTAAAACCGAGCTCTCTAAACAGTTAGCCATCGAGCTCTTTGGTTCATCTGATAGTATGAT
TCGTTTTGACATGTCAGAATACATGGAAAAACACGCTGTTGCTAAATTGGTCGGTGCTCCTCCAGGCTATGTTGGTTACG
ACGAAGCTGGGCAATTAACTGAAAAAGTCCGCCGTAACCCTTATTCACTCATTCTCCTTGATGAGATTGAAAAAGCTCAC
CCAGATGTTCTTCACATGTTCCTTCAGGTACTTGACGATGGTCGTCTGACTGATGGTCAAGGTAGAACTGTAAGTTTCAA
AGATACCATCATCATCATGACTTCAAATGCTGGTACTGGTAAAGTGGAAGCTAGTGTAGGTTTTGGAGCTGCTCGTGAGA
ATCGTACCAATTCTATTATCAACCAACTCGGAGATTTCTTCAGTCCTGAATTCATGAACCGTTTTGACGGTATTATCGAG
TTCAATGCCCTAAGCAAGGAAAATCTCCTTACTATCGTGGACCTTATGCTTGATGGCGTCAACCAACGCTTGGCAAACAA
CGGTATCTACCTCAGTGTAACTGATAAAGTTAAGGAAAAACTGGTTGACCTTGGTTATGATCCTAAGATGGGTGCTCGAC
CATTGCGTCGTACAATCCAAGACCACATTGAAGATGCTATTACAGACTTCTACCTTAAAAATCCAAATGAAAAAGATCTC
AAGGCTGTAATGACTTCAAAGGGGAACATCACCATTAAATCTGCTAAAAAAACTGAAAAAACTTCTCAGAAAACTGAAGC
ATTAAAAGAAGCCAACTAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(644-717)

AAA domain (Cdc48 subfamily) (AAA_2)

(473-636)

ATPase family associated with various cellular activities (AAA) (AAA)

(150-265)

AAA lid domain (AAA_lid_9)

(288-386)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

83.888

99.867

0.838
  clpE Streptococcus pneumoniae Rx1

81.782

100

0.818
  clpE Streptococcus pneumoniae D39

81.782

100

0.818
  clpE Streptococcus pneumoniae R6

81.782

100

0.818
  clpE Streptococcus pneumoniae TIGR4

81.649

100

0.816
  clpC Lactococcus lactis subsp. cremoris KW2

75.726

100

0.763
  clpC Bacillus subtilis subsp. subtilis str. 168

52.234

86.303

0.451
  clpC Streptococcus pneumoniae Rx1

46.984

83.777

0.394
  clpC Streptococcus pneumoniae D39

46.984

83.777

0.394
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.2

83.112

0.392
  clpC Streptococcus pneumoniae TIGR4

46.825

83.777

0.392
  clpC Streptococcus thermophilus LMG 18311

46.89

83.378

0.391
  clpC Streptococcus thermophilus LMD-9

47.04

83.112

0.391
  clpC Streptococcus mutans UA159

46.645

83.245

0.388

Multiple sequence alignment