Detailed information
Bioinformatically predicted
Overview
| Name | endA | Type | Machinery gene |
| Locus tag | H1W98_RS05710 | Genome accession | NZ_LR822026 |
| Coordinates | 1082483..1083364 (-) | Length | 293 a.a. |
| NCBI ID | WP_084828863.1 | Uniprot ID | A0A0E2QH56 |
| Organism | Streptococcus thermophilus isolate STH_CIRM_967 | ||
| Function | cleavage of dsDNA into ssDNA (predicted from homology) DNA processing |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 1071841..1109258 | 1082483..1083364 | within | 0 |
| IScluster/Tn | 1078277..1082234 | 1082483..1083364 | flank | 249 |
Gene organization within MGE regions
Location: 1071841..1109258
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H1W98_RS05645 (STHERMO_1271) | vicX | 1071841..1072653 (-) | 813 | WP_179971933.1 | MBL fold metallo-hydrolase | Regulator |
| H1W98_RS05650 (STHERMO_1272) | vicK | 1072659..1073999 (-) | 1341 | WP_179971934.1 | cell wall metabolism sensor histidine kinase VicK | Regulator |
| H1W98_RS05655 (STHERMO_1273) | vicR | 1073992..1074699 (-) | 708 | WP_179971935.1 | response regulator YycF | Regulator |
| H1W98_RS05660 (STHERMO_1275) | - | 1075223..1075990 (+) | 768 | WP_180482604.1 | amino acid ABC transporter ATP-binding protein | - |
| H1W98_RS05665 (STHERMO_1276) | - | 1076002..1076835 (+) | 834 | WP_180482603.1 | transporter substrate-binding domain-containing protein | - |
| H1W98_RS05670 (STHERMO_1277) | - | 1076853..1077551 (+) | 699 | WP_179971938.1 | amino acid ABC transporter permease | - |
| H1W98_RS05675 (STHERMO_1278) | - | 1077563..1078213 (+) | 651 | WP_179971939.1 | amino acid ABC transporter permease | - |
| H1W98_RS05680 (STHERMO_1280) | - | 1078277..1079533 (-) | 1257 | WP_180483860.1 | ISL3 family transposase | - |
| H1W98_RS05685 (STHERMO_1281) | - | 1079665..1080141 (-) | 477 | WP_179971941.1 | transposase | - |
| H1W98_RS11365 | - | 1080184..1080342 (+) | 159 | WP_179973363.1 | hypothetical protein | - |
| H1W98_RS05695 | - | 1080395..1080922 (+) | 528 | WP_179971942.1 | HdeD family acid-resistance protein | - |
| H1W98_RS10815 (STHERMO_1285) | - | 1081051..1082308 (-) | 1258 | Protein_1070 | ISL3 family transposase | - |
| H1W98_RS05710 (STHERMO_1287) | endA | 1082483..1083364 (-) | 882 | WP_084828863.1 | DNA/RNA non-specific endonuclease | Machinery gene |
| H1W98_RS05715 (STHERMO_1288) | - | 1083426..1083614 (-) | 189 | WP_011226090.1 | DNA-directed RNA polymerase subunit beta | - |
| H1W98_RS05720 (STHERMO_1289) | murA | 1083616..1084887 (-) | 1272 | WP_180482602.1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | - |
| H1W98_RS05725 (STHERMO_1290) | - | 1084955..1085191 (-) | 237 | WP_002946959.1 | DUF1146 family protein | - |
| H1W98_RS05730 (STHERMO_1291) | galE | 1085379..1086392 (-) | 1014 | WP_180482601.1 | UDP-glucose 4-epimerase GalE | - |
| H1W98_RS05735 (STHERMO_1292) | - | 1086407..1086862 (-) | 456 | WP_180482600.1 | DUF4832 domain-containing protein | - |
| H1W98_RS05740 (STHERMO_1293) | metK | 1087886..1089079 (-) | 1194 | WP_180482599.1 | methionine adenosyltransferase | - |
| H1W98_RS05745 (STHERMO_1294) | birA | 1089359..1090297 (+) | 939 | WP_011681223.1 | bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA | - |
| H1W98_RS05750 (STHERMO_1295) | - | 1090284..1090469 (-) | 186 | WP_011681224.1 | DUF3272 family protein | - |
| H1W98_RS05755 (STHERMO_1296) | dnaX | 1090608..1092260 (-) | 1653 | WP_179971950.1 | DNA polymerase III subunit gamma/tau | - |
| H1W98_RS05760 (STHERMO_1297) | - | 1092260..1092760 (-) | 501 | WP_171815269.1 | GAF domain-containing protein | - |
| H1W98_RS05765 (STHERMO_1298) | miaA | 1092805..1093704 (-) | 900 | WP_179971952.1 | tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA | - |
| H1W98_RS05770 (STHERMO_1299) | - | 1093781..1093957 (+) | 177 | WP_014727550.1 | DUF3042 family protein | - |
| H1W98_RS05775 (STHERMO_1301) | - | 1094353..1094547 (-) | 195 | WP_180482598.1 | hypothetical protein | - |
| H1W98_RS05780 (STHERMO_1302) | - | 1094560..1094769 (-) | 210 | WP_180482597.1 | helix-turn-helix domain-containing protein | - |
| H1W98_RS05785 (STHERMO_1303) | - | 1095076..1095426 (+) | 351 | WP_180482596.1 | helix-turn-helix domain-containing protein | - |
| H1W98_RS05790 (STHERMO_1304) | - | 1095429..1096310 (+) | 882 | WP_180482595.1 | hypothetical protein | - |
| H1W98_RS05795 (STHERMO_1306) | - | 1096556..1096924 (+) | 369 | WP_180482594.1 | ImmA/IrrE family metallo-endopeptidase | - |
| H1W98_RS05800 (STHERMO_1307) | - | 1097008..1097619 (+) | 612 | WP_232086966.1 | CD20-like domain-containing protein | - |
| H1W98_RS05805 (STHERMO_1308) | - | 1097724..1098461 (+) | 738 | WP_232086965.1 | Arm DNA-binding domain-containing protein | - |
| H1W98_RS10820 | - | 1098589..1098765 (+) | 177 | WP_232086976.1 | tyrosine-type recombinase/integrase | - |
| H1W98_RS05815 (STHERMO_1311) | - | 1098936..1100185 (+) | 1250 | Protein_1092 | ISL3 family transposase | - |
| H1W98_RS05825 (STHERMO_1312) | rplS | 1100357..1100704 (-) | 348 | WP_002950935.1 | 50S ribosomal protein L19 | - |
| H1W98_RS05830 (STHERMO_1313) | - | 1100832..1102058 (-) | 1227 | WP_180482593.1 | voltage-gated chloride channel family protein | - |
| H1W98_RS05835 (STHERMO_1314) | - | 1102068..1102340 (-) | 273 | WP_011226101.1 | chorismate mutase | - |
| H1W98_RS05840 (STHERMO_1315) | - | 1102415..1103950 (-) | 1536 | WP_180482592.1 | ClC family H(+)/Cl(-) exchange transporter | - |
| H1W98_RS05845 (STHERMO_1316) | - | 1104001..1104444 (-) | 444 | WP_002888085.1 | flavodoxin | - |
| H1W98_RS05850 (STHERMO_1318) | - | 1104529..1104900 (-) | 372 | WP_179971956.1 | hypothetical protein | - |
| H1W98_RS05855 (STHERMO_1319) | - | 1104912..1105631 (-) | 720 | WP_180482591.1 | matrixin family metalloprotease | - |
| H1W98_RS05860 (STHERMO_1320) | - | 1105751..1106533 (-) | 783 | WP_180482590.1 | alpha/beta hydrolase | - |
| H1W98_RS05865 (STHERMO_1321) | - | 1106658..1108319 (-) | 1662 | WP_179971958.1 | ribonuclease J | - |
| H1W98_RS05870 (STHERMO_1322) | - | 1108500..1109258 (-) | 759 | WP_179971959.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 293 a.a. Molecular weight: 31768.48 Da Isoelectric Point: 10.0031
>NTDB_id=1131285 H1W98_RS05710 WP_084828863.1 1082483..1083364(-) (endA) [Streptococcus thermophilus isolate STH_CIRM_967]
MAKGKTSLTNKQKRQFVTLIIAALIAVLGYLGTSNKLSPDNPIRQVASLVSGKSNKSIKSNYLTNSQSTPQEQLAETVMT
SSVKSQLGNSLEWNGAGAYIINGNKTNLNAKVSSQPYANNQVKTVQGQTVPTVANALLSKATRQYKNRQETGNGSTSWTP
AGWHQVQNLSGEYSHAVDRGHLLGYALIGGLKGFDASTSNPENIAVQTAWANQAYSDNSTGQNYYESLVRKALDKNKRVR
YRVTLIYEGENLIPSGTHLEAKSADGSLEFNVFVPNVQEGITLDYYSGKVTVN
MAKGKTSLTNKQKRQFVTLIIAALIAVLGYLGTSNKLSPDNPIRQVASLVSGKSNKSIKSNYLTNSQSTPQEQLAETVMT
SSVKSQLGNSLEWNGAGAYIINGNKTNLNAKVSSQPYANNQVKTVQGQTVPTVANALLSKATRQYKNRQETGNGSTSWTP
AGWHQVQNLSGEYSHAVDRGHLLGYALIGGLKGFDASTSNPENIAVQTAWANQAYSDNSTGQNYYESLVRKALDKNKRVR
YRVTLIYEGENLIPSGTHLEAKSADGSLEFNVFVPNVQEGITLDYYSGKVTVN
Nucleotide
Download Length: 882 bp
>NTDB_id=1131285 H1W98_RS05710 WP_084828863.1 1082483..1083364(-) (endA) [Streptococcus thermophilus isolate STH_CIRM_967]
ATGGCAAAAGGAAAAACATCTTTGACAAATAAACAGAAACGTCAGTTCGTCACATTAATAATAGCAGCTTTGATAGCTGT
TTTAGGTTACCTAGGAACCAGCAACAAGCTCTCGCCTGATAATCCTATCAGACAAGTAGCAAGCCTAGTTTCAGGAAAAT
CTAATAAATCCATTAAATCTAATTATTTAACAAATAGTCAGTCTACACCACAAGAGCAGCTTGCTGAGACAGTAATGACT
AGTTCAGTCAAAAGCCAACTGGGTAATTCCTTGGAATGGAATGGAGCTGGAGCCTATATTATTAATGGAAATAAGACGAA
TCTAAATGCTAAGGTATCAAGCCAACCTTATGCTAATAACCAAGTCAAAACGGTTCAAGGACAAACTGTTCCTACAGTTG
CTAATGCCTTATTAAGTAAAGCAACTAGACAGTACAAAAATCGTCAAGAAACAGGGAATGGTTCAACCTCTTGGACACCA
GCTGGATGGCACCAGGTTCAAAATTTATCAGGAGAGTATAGCCATGCCGTAGATAGAGGCCATTTGCTAGGTTATGCACT
GATAGGTGGTTTGAAAGGATTTGATGCCTCGACTTCAAATCCAGAGAATATTGCTGTTCAAACTGCTTGGGCAAATCAAG
CATATAGCGATAATTCTACAGGTCAAAACTATTATGAAAGCCTAGTACGAAAAGCTCTGGATAAAAACAAACGTGTTCGT
TATCGTGTGACCTTGATTTATGAAGGAGAGAACCTCATTCCATCAGGAACACATCTTGAAGCTAAGTCAGCAGACGGATC
ACTTGAGTTTAATGTCTTTGTTCCAAATGTACAAGAGGGAATAACCCTAGATTACTATTCAGGAAAAGTAACGGTGAATT
GA
ATGGCAAAAGGAAAAACATCTTTGACAAATAAACAGAAACGTCAGTTCGTCACATTAATAATAGCAGCTTTGATAGCTGT
TTTAGGTTACCTAGGAACCAGCAACAAGCTCTCGCCTGATAATCCTATCAGACAAGTAGCAAGCCTAGTTTCAGGAAAAT
CTAATAAATCCATTAAATCTAATTATTTAACAAATAGTCAGTCTACACCACAAGAGCAGCTTGCTGAGACAGTAATGACT
AGTTCAGTCAAAAGCCAACTGGGTAATTCCTTGGAATGGAATGGAGCTGGAGCCTATATTATTAATGGAAATAAGACGAA
TCTAAATGCTAAGGTATCAAGCCAACCTTATGCTAATAACCAAGTCAAAACGGTTCAAGGACAAACTGTTCCTACAGTTG
CTAATGCCTTATTAAGTAAAGCAACTAGACAGTACAAAAATCGTCAAGAAACAGGGAATGGTTCAACCTCTTGGACACCA
GCTGGATGGCACCAGGTTCAAAATTTATCAGGAGAGTATAGCCATGCCGTAGATAGAGGCCATTTGCTAGGTTATGCACT
GATAGGTGGTTTGAAAGGATTTGATGCCTCGACTTCAAATCCAGAGAATATTGCTGTTCAAACTGCTTGGGCAAATCAAG
CATATAGCGATAATTCTACAGGTCAAAACTATTATGAAAGCCTAGTACGAAAAGCTCTGGATAAAAACAAACGTGTTCGT
TATCGTGTGACCTTGATTTATGAAGGAGAGAACCTCATTCCATCAGGAACACATCTTGAAGCTAAGTCAGCAGACGGATC
ACTTGAGTTTAATGTCTTTGTTCCAAATGTACAAGAGGGAATAACCCTAGATTACTATTCAGGAAAAGTAACGGTGAATT
GA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| endA | Streptococcus pneumoniae Rx1 |
75.893 |
76.451 |
0.58 |
| endA | Streptococcus pneumoniae D39 |
75.893 |
76.451 |
0.58 |
| endA | Streptococcus pneumoniae R6 |
75.893 |
76.451 |
0.58 |
| endA | Streptococcus pneumoniae TIGR4 |
75.893 |
76.451 |
0.58 |