Detailed information NTG1131074

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: H0514_RS02065
• Genome accession: NZ_LR822020
• Coordinates: 388580..389656 (+)
• Length: 358 a.a.
• NCBI ID: WP_179972223.1
• Uniprot ID: A0A7U7C886
• Organism: Streptococcus thermophilus isolate STH_CIRM_956
• Function: processing of CSP (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	389750..391054	388580..389656	flank	94

Gene organization within MGE regions

Location: 388580..391054

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0514_RS02065 (STHERMO_0463)	sepM	388580..389656 (+)	1077	WP_179972223.1	SepM family pheromone-processing serine protease	Regulator
H0514_RS02070 (STHERMO_0464)	-	389750..391006 (-)	1257	Protein_365	ISL3 family transposase	-

Sequence

Protein

• Length: 358 a.a.
• Molecular weight: 39237.27 Da
• Isoelectric Point: 9.7882

>NTDB_id=1131074 H0514_RS02065 WP_179972223.1 388580..389656(+) (sepM) [Streptococcus thermophilus isolate STH_CIRM_956]
MANKTKSKSLLEKMWRIKWWLLSIFTLLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAKFNDFAKLQTAEEATGNYSDEDFIRINKFYMETSQNQAVYQGLTLAGKEVSLKYMGVYVLQVADDSSFKGVLN
IADTVTAVNGKTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLIFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGTVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKVDPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK

Nucleotide

• Length: 1077 bp

>NTDB_id=1131074 H0514_RS02065 WP_179972223.1 388580..389656(+) (sepM) [Streptococcus thermophilus isolate STH_CIRM_956]
GTGGCAAACAAGACAAAATCTAAATCGCTACTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGTT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCTCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTAAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATACGCATCAACAAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGAAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATCGCTGATACGGTGACGGCTGTTAATGGTAAGACCTTTGATAATTCGACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGTAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAAATTAAGAGTCCTGAGAATGTTAAGTTTAAACTAGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATATTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGACTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGTCGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGCACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (244-321)

• PDZ domain (PDZ_2) (140-206)

3D structure

• AlphaFold DB: A0A7U7C886

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	62.463	95.251	0.595