Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   H0508_RS02965 Genome accession   NZ_LR822014
Coordinates   564220..566478 (-) Length   752 a.a.
NCBI ID   WP_011225684.1    Uniprot ID   A0AAP2RLR5
Organism   Streptococcus thermophilus isolate STH_CIRM_36     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 559220..571478
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H0508_RS09470 (STHERMO_0619) - 559617..559853 (+) 237 WP_232085760.1 hypothetical protein -
  H0508_RS09475 (STHERMO_0620) - 559903..560238 (+) 336 Protein_529 DUF3862 domain-containing protein -
  H0508_RS02940 (STHERMO_0621) - 560450..560875 (+) 426 WP_011225681.1 hypothetical protein -
  H0508_RS02945 (STHERMO_0622) - 560971..562206 (+) 1236 WP_011225682.1 aminoacyltransferase -
  H0508_RS02950 - 562305..563266 (+) 962 Protein_532 Gfo/Idh/MocA family protein -
  H0508_RS02955 (STHERMO_0627) - 563307..563609 (-) 303 WP_002947303.1 DUF1827 family protein -
  H0508_RS02960 (STHERMO_0628) - 563619..564077 (-) 459 WP_002947302.1 NUDIX hydrolase -
  H0508_RS02965 (STHERMO_0629) clpE 564220..566478 (-) 2259 WP_011225684.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  H0508_RS02970 (STHERMO_0630) argF 566719..567699 (+) 981 WP_041826989.1 ornithine carbamoyltransferase -
  H0508_RS02975 (STHERMO_0631) - 567768..567998 (+) 231 WP_011225686.1 DUF1797 family protein -
  H0508_RS02980 (STHERMO_0632) - 568267..568947 (+) 681 WP_014608117.1 amino acid ABC transporter permease -
  H0508_RS02985 (STHERMO_0633) - 568947..569681 (+) 735 WP_011225688.1 amino acid ABC transporter ATP-binding protein -
  H0508_RS02990 (STHERMO_0634) - 569855..570331 (+) 477 WP_011225689.1 ferrous iron transport protein A -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83756.92 Da        Isoelectric Point: 5.2102

>NTDB_id=1130845 H0508_RS02965 WP_011225684.1 564220..566478(-) (clpE) [Streptococcus thermophilus isolate STH_CIRM_36]
MLCQNCNLNEASIHLYTNVNGNQQQVDLCQHCYKIIKSDPENPLNQFNQAGGSNFFDDFFSDLNNFRSSNGDLPNTPPTQ
EGGNRGNGGPGRPGGPRQQAPQQPQGLLEEFGINITDIARRGDIDPVIGRDEEIIRVIEILNRRTKNNPVLIGEPGVGKT
AVVEGLAQKIVDGDVPQKLQSKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVGAGNTGDGNM
DAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILRGIQPKYQDYHHVKYTDEAITAAA
ELSNRYIQDRFLPDKAIDLLDESGSKMNLTLNFIDPKDLDKRLIEAENLKAQATRDEDFEKAAYFRDQIAKYKEMQQQTI
KDQDMPIITEKHIEAIVEQKTNIPIGDLKEKEQSQLLNLADDLKAHVIGQDAAVDKIAKAIRRNRVGLGAPNRPIGSFLF
VGPTGVGKTELSKQLAIELFGSSDSMIRFDMSEYMEKHAVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDEVEKAH
PDVLHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAARENRTNSVINHLGDFFSPEFMNRFDGIIE
FSALSKENLLTIVDLMLDGVNQRLANNGIHLSVTDKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLKNPNEKDL
KAVMTSKGHITIKSAKKTEKTSQKTEALKEVN

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=1130845 H0508_RS02965 WP_011225684.1 564220..566478(-) (clpE) [Streptococcus thermophilus isolate STH_CIRM_36]
ATGCTCTGCCAAAACTGTAACCTTAATGAAGCTAGTATCCATTTGTATACCAACGTAAATGGTAATCAGCAACAAGTTGA
CCTCTGTCAACATTGTTATAAAATCATAAAATCTGATCCAGAGAACCCCCTTAACCAATTCAATCAAGCAGGAGGTTCCA
ACTTCTTCGACGATTTCTTCAGTGACCTAAACAACTTCCGTTCTTCTAACGGAGACCTTCCTAATACACCTCCAACACAA
GAGGGAGGTAACCGTGGAAACGGTGGTCCAGGCCGTCCTGGAGGACCACGTCAACAAGCCCCTCAACAACCTCAAGGCCT
TCTCGAAGAATTTGGAATTAATATCACAGATATTGCTCGTCGTGGAGACATTGATCCTGTCATTGGTCGTGACGAAGAAA
TCATTCGCGTCATCGAAATTCTGAACCGCCGTACCAAGAACAATCCTGTTCTTATCGGTGAACCTGGTGTTGGTAAGACC
GCAGTAGTCGAAGGACTTGCCCAAAAAATCGTTGATGGAGATGTGCCACAAAAACTCCAAAGCAAGCAAGTTATCCGTCT
TGATGTTGTAAGCCTAGTTCAAGGGACTGGTATCCGCGGCCAGTTCGAAGAACGCATGCAAAAGCTCATGGAGGAAATCC
GCCAACGTCAGGATGTTATCCTCTTTATTGATGAAATCCATGAAATTGTAGGAGCTGGTAATACTGGGGACGGCAATATG
GATGCTGGAAACATCTTAAAACCTGCACTTGCCCGTGGAGAGCTTCAACTTGTTGGAGCAACAACACTCAACGAATACCG
TATCATTGAGAAAGATGCGGCACTCGAACGTCGTATGCAACCTGTTAAGGTAGATGAGCCAACAGTTGAGGAAACAATCA
CAATTTTGCGTGGTATCCAGCCTAAATATCAAGACTACCACCATGTCAAATACACTGATGAAGCCATTACTGCAGCTGCA
GAATTATCCAACCGCTACATTCAGGACCGTTTCTTGCCAGACAAGGCCATCGACCTTCTCGATGAATCTGGCTCTAAGAT
GAATTTAACCCTCAACTTTATCGATCCTAAGGACCTCGATAAACGTTTGATTGAAGCTGAGAATCTTAAAGCTCAGGCTA
CTCGTGACGAAGACTTTGAAAAAGCTGCTTATTTCCGTGACCAAATTGCTAAATACAAGGAAATGCAACAGCAAACCATC
AAAGACCAAGATATGCCTATCATTACTGAAAAACATATCGAAGCCATTGTCGAGCAAAAAACCAATATTCCTATCGGTGA
TTTAAAAGAAAAAGAACAATCTCAACTTCTCAACCTCGCCGATGACCTTAAGGCGCATGTTATTGGCCAAGATGCTGCAG
TTGATAAGATTGCCAAAGCTATCCGCCGTAATCGTGTTGGACTTGGTGCACCAAACCGCCCAATTGGTAGCTTCCTATTT
GTAGGCCCTACAGGAGTCGGTAAAACTGAGCTCTCTAAACAGTTAGCCATCGAGCTCTTTGGTTCATCTGATAGTATGAT
TCGTTTTGACATGTCAGAATACATGGAAAAACACGCTGTTGCTAAATTGGTCGGTGCTCCTCCAGGCTATGTTGGTTACG
ACGAAGCTGGGCAATTAACCGAAAAGGTCCGCCGTAACCCTTACTCACTCATTCTCCTTGATGAGGTTGAAAAAGCTCAC
CCAGATGTACTTCACATGTTTCTTCAGGTACTTGACGATGGTCGTCTGACTGATGGTCAAGGGAGAACTGTAAGTTTCAA
AGATACCATCATCATCATGACTTCAAATGCTGGTACTGGTAAAGTGGAAGCAAGTGTAGGCTTTGGAGCTGCTCGTGAGA
ATCGTACCAATTCTGTTATCAACCACCTTGGAGATTTCTTCAGTCCTGAATTCATGAACCGTTTTGACGGTATTATCGAG
TTCTCTGCCCTAAGCAAGGAAAATCTCCTTACTATCGTGGACCTTATGCTTGATGGCGTCAACCAACGCTTGGCAAACAA
CGGTATCCACCTCAGTGTGACTGATAAAGTTAAGGAAAAACTGGTTGACCTTGGTTATGATCCTAAGATGGGTGCTCGAC
CATTGCGTCGTACAATCCAAGACCATATCGAAGATGCCATTACAGACTTCTACCTTAAAAATCCAAATGAAAAAGATCTC
AAGGCTGTAATGACTTCAAAGGGACACATCACCATTAAATCTGCTAAAAAAACTGAAAAAACTTCTCAGAAAACTGAAGC
ATTAAAAGAAGTCAACTAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(644-717)

AAA lid domain (AAA_lid_9)

(288-386)

ATPase family associated with various cellular activities (AAA) (AAA)

(150-269)

AAA domain (Cdc48 subfamily) (AAA_2)

(473-636)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

84.554

99.867

0.844
  clpE Streptococcus pneumoniae Rx1

82.181

100

0.822
  clpE Streptococcus pneumoniae D39

82.181

100

0.822
  clpE Streptococcus pneumoniae R6

82.181

100

0.822
  clpE Streptococcus pneumoniae TIGR4

82.048

100

0.82
  clpC Lactococcus lactis subsp. cremoris KW2

76.502

99.601

0.762
  clpC Bacillus subtilis subsp. subtilis str. 168

51.772

86.303

0.447
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.037

87.234

0.402
  clpC Streptococcus pneumoniae Rx1

46.984

83.777

0.394
  clpC Streptococcus pneumoniae D39

46.984

83.777

0.394
  clpC Streptococcus pneumoniae TIGR4

46.825

83.777

0.392
  clpC Streptococcus mutans UA159

46.326

83.245

0.386
  clpC Streptococcus thermophilus LMD-9

46.4

83.112

0.386
  clpC Streptococcus thermophilus LMG 18311

46.08

83.112

0.383

Multiple sequence alignment