Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   H0505_RS02980 Genome accession   NZ_LR822012
Coordinates   562225..564483 (-) Length   752 a.a.
NCBI ID   WP_179971249.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_30     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 557225..569483
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H0505_RS09590 (STHERMO_0616) - 557620..557856 (+) 237 WP_011226995.1 hypothetical protein -
  H0505_RS09595 (STHERMO_0617) - 557906..558241 (+) 336 Protein_528 DUF3862 domain-containing protein -
  H0505_RS02955 (STHERMO_0618) - 558505..558996 (+) 492 WP_232085735.1 TVP38/TMEM64 family protein -
  H0505_RS02960 (STHERMO_0619) - 558974..560209 (+) 1236 WP_014608114.1 aminoacyltransferase -
  H0505_RS02965 - 560308..561271 (+) 964 Protein_531 Gfo/Idh/MocA family protein -
  H0505_RS02970 (STHERMO_0623) - 561312..561614 (-) 303 WP_011680916.1 DUF1827 family protein -
  H0505_RS02975 (STHERMO_0624) - 561624..562082 (-) 459 WP_002947302.1 NUDIX hydrolase -
  H0505_RS02980 (STHERMO_0625) clpE 562225..564483 (-) 2259 WP_179971249.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  H0505_RS02985 (STHERMO_0626) argF 564724..565704 (+) 981 WP_179971250.1 ornithine carbamoyltransferase -
  H0505_RS02990 (STHERMO_0627) - 565773..566003 (+) 231 WP_011225686.1 DUF1797 family protein -
  H0505_RS02995 (STHERMO_0628) - 566273..566953 (+) 681 WP_014608117.1 amino acid ABC transporter permease -
  H0505_RS03000 (STHERMO_0629) - 566953..567687 (+) 735 WP_011225688.1 amino acid ABC transporter ATP-binding protein -
  H0505_RS03005 (STHERMO_0630) - 567860..568336 (+) 477 WP_011225689.1 ferrous iron transport protein A -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83706.91 Da        Isoelectric Point: 5.3405

>NTDB_id=1130727 H0505_RS02980 WP_179971249.1 562225..564483(-) (clpE) [Streptococcus thermophilus isolate STH_CIRM_30]
MLCQNCNLNEASIHLYTNVNGNQQQVDLCQHCYKIIKSDPENPLNQFNQAGGSNFFDDFFSDLNNFRSSNGDLPNTPPTQ
EGGNRGNGGPGRPGGPRQQAPQQPQGLLEEFGINITDIARRGDIDPVIGRDEEIIRVIEILNRRTKNNPVLIGEPGVGKT
AVVEGLAQKIVDGDVPQKLQSKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRQRQDVILFIDEIHEIVGAGNTGDGNM
DAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILRGIQPKYQDYHHVKYTDEAITAAA
ELSNRYIQDHFLPDKAIDLLDESGSKMNLTLNFIDPKDLDKRLIEAENLKAQATRDEDFEKAAYFRDQIAKYKEMQQQTI
KDQDMPIITEKHIEAIVEQKTNIPIGDLKEKEQSQLLNLADDLKAHVIGQDAAVDKIAKAIRRNRVGLGAPNRPIGSFLF
VGPTGVGKTELSKQLAIELFGSSDSMIRFDMSEYMEKHAVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDEVEKAH
PDVLHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAARENRTNSVINHLGDFFSPEFMNRFDGIIE
FSALSKKNLLTIVDLMLDGVNQRLANNGIHLSVADKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLKNPNEKDL
KAVMTSKGHITIKSAKKTEKTSQKTEALKEVN

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=1130727 H0505_RS02980 WP_179971249.1 562225..564483(-) (clpE) [Streptococcus thermophilus isolate STH_CIRM_30]
ATGCTCTGCCAAAACTGTAACCTTAATGAAGCTAGTATCCATTTGTATACCAACGTAAATGGTAATCAGCAACAAGTTGA
CCTCTGTCAACATTGTTATAAAATCATAAAATCTGATCCAGAGAACCCCCTTAACCAATTCAATCAAGCAGGAGGTTCCA
ACTTCTTCGACGATTTCTTCAGTGACCTAAACAACTTCCGTTCTTCTAACGGAGACCTTCCTAATACACCTCCAACACAA
GAGGGAGGTAACCGTGGAAACGGTGGTCCAGGCCGTCCTGGAGGACCACGTCAACAAGCCCCTCAACAACCTCAAGGCCT
TCTCGAAGAATTTGGAATTAATATCACAGATATTGCTCGTCGTGGAGACATTGATCCTGTCATTGGTCGTGACGAAGAAA
TCATTCGCGTCATCGAAATTCTGAACCGCCGTACCAAGAACAATCCTGTTCTTATCGGTGAACCTGGTGTTGGTAAGACC
GCAGTAGTCGAAGGACTTGCCCAAAAAATCGTTGATGGAGATGTGCCACAAAAACTCCAAAGCAAGCAAGTTATCCGTCT
TGATGTTGTAAGCCTAGTTCAAGGGACTGGTATCCGCGGCCAGTTCGAAGAACGCATGCAAAAGCTCATGGAGGAAATCC
GCCAACGTCAGGATGTTATCCTCTTTATTGATGAAATCCATGAAATTGTAGGAGCTGGTAATACTGGGGACGGCAATATG
GATGCTGGAAACATCTTAAAACCTGCACTTGCCCGTGGAGAGCTTCAACTTGTTGGAGCAACAACACTCAACGAATACCG
TATCATTGAGAAAGATGCGGCACTCGAACGTCGTATGCAACCTGTTAAGGTAGATGAGCCAACAGTTGAGGAAACAATCA
CAATTTTGCGTGGTATCCAGCCTAAATATCAAGACTACCACCATGTCAAATACACTGATGAAGCCATTACTGCAGCTGCA
GAATTATCCAACCGCTACATTCAGGACCATTTCTTGCCAGACAAGGCCATCGACCTTCTCGATGAATCTGGCTCTAAGAT
GAATTTAACCCTCAACTTTATCGATCCTAAGGACCTCGATAAACGTTTGATTGAAGCTGAGAATCTTAAAGCTCAGGCTA
CTCGTGACGAAGACTTTGAAAAAGCTGCTTATTTCCGTGACCAAATTGCTAAATACAAGGAAATGCAACAGCAAACCATC
AAAGACCAAGATATGCCTATCATTACTGAAAAACATATCGAAGCCATTGTCGAGCAAAAAACCAATATTCCTATCGGTGA
TTTAAAAGAAAAAGAACAATCTCAACTTCTCAACCTCGCCGATGACCTTAAGGCGCATGTTATTGGCCAAGATGCCGCAG
TTGATAAGATTGCCAAAGCTATCCGCCGTAATCGTGTTGGACTTGGTGCACCAAACCGCCCAATTGGTAGCTTCCTATTT
GTAGGCCCTACAGGAGTCGGTAAAACTGAGCTCTCTAAACAGTTAGCCATCGAGCTCTTTGGTTCATCTGATAGTATGAT
TCGTTTTGACATGTCAGAATACATGGAAAAACACGCTGTTGCTAAATTGGTCGGTGCTCCTCCAGGCTATGTTGGTTACG
ACGAAGCTGGGCAATTAACCGAAAAGGTCCGCCGTAACCCTTATTCACTCATTCTCCTTGATGAGGTTGAAAAAGCTCAC
CCAGATGTGCTTCACATGTTCCTTCAGGTACTCGACGATGGTCGTCTGACTGATGGTCAAGGGAGAACTGTAAGTTTCAA
AGATACCATCATCATCATGACTTCAAATGCTGGTACTGGTAAAGTGGAAGCAAGTGTAGGTTTTGGAGCTGCTCGTGAGA
ATCGTACCAATTCTGTTATCAACCACCTTGGAGATTTCTTCAGTCCTGAATTCATGAACCGTTTTGACGGTATTATCGAG
TTCTCTGCCCTAAGCAAGAAAAATCTCCTTACTATCGTGGACCTTATGCTTGATGGCGTCAACCAACGCTTGGCAAACAA
CGGTATCCACCTCAGTGTGGCTGATAAAGTTAAGGAAAAACTGGTTGACCTTGGTTATGATCCTAAGATGGGTGCTCGAC
CATTGCGTCGTACAATCCAAGACCACATCGAAGATGCCATTACAGACTTCTACCTTAAAAATCCAAATGAAAAAGATCTC
AAGGCTGTAATGACTTCAAAGGGACACATCACCATTAAATCTGCTAAAAAAACTGAAAAAACTTCTCAGAAAACTGAAGC
ATTAAAAGAAGTCAACTAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(644-717)

ATPase family associated with various cellular activities (AAA) (AAA)

(150-269)

AAA lid domain (AAA_lid_9)

(288-386)

AAA domain (Cdc48 subfamily) (AAA_2)

(473-636)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

84.288

99.867

0.842
  clpE Streptococcus pneumoniae Rx1

81.915

100

0.819
  clpE Streptococcus pneumoniae D39

81.915

100

0.819
  clpE Streptococcus pneumoniae R6

81.915

100

0.819
  clpE Streptococcus pneumoniae TIGR4

81.782

100

0.818
  clpC Lactococcus lactis subsp. cremoris KW2

76.101

99.601

0.758
  clpC Bacillus subtilis subsp. subtilis str. 168

51.618

86.303

0.445
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

45.884

87.234

0.4
  clpC Streptococcus pneumoniae Rx1

46.825

83.777

0.392
  clpC Streptococcus pneumoniae D39

46.825

83.777

0.392
  clpC Streptococcus pneumoniae TIGR4

46.667

83.777

0.391
  clpC Streptococcus thermophilus LMD-9

46.24

83.112

0.384
  clpC Streptococcus mutans UA159

46.166

83.245

0.384
  clpC Streptococcus thermophilus LMG 18311

45.92

83.112

0.382

Multiple sequence alignment