Detailed information NTG1130617

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: H0507_RS05485
• Genome accession: NZ_LR822010
• Coordinates: 1027693..1028574 (-)
• Length: 293 a.a.
• NCBI ID: WP_011226089.1
• Uniprot ID: Q5M441
• Organism: Streptococcus thermophilus isolate STH_CIRM_29
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1022693..1033574

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H0507_RS05460 (STHERMO_1188)	vicR	1023393..1024100 (-)	708	WP_011227274.1	response regulator YycF	Regulator
H0507_RS05465 (STHERMO_1190)	-	1024632..1025399 (+)	768	WP_179971832.1	amino acid ABC transporter ATP-binding protein	-
H0507_RS05470 (STHERMO_1191)	-	1025411..1026244 (+)	834	WP_011227276.1	transporter substrate-binding domain-containing protein	-
H0507_RS05475 (STHERMO_1192)	-	1026262..1026960 (+)	699	WP_011226087.1	amino acid ABC transporter permease	-
H0507_RS05480 (STHERMO_1193)	-	1026972..1027622 (+)	651	WP_011226088.1	amino acid ABC transporter permease	-
H0507_RS05485 (STHERMO_1194)	endA	1027693..1028574 (-)	882	WP_011226089.1	DNA/RNA non-specific endonuclease	Machinery gene
H0507_RS05490 (STHERMO_1195)	-	1028636..1028824 (-)	189	WP_011227277.1	DNA-directed RNA polymerase subunit beta	-
H0507_RS05495 (STHERMO_1196)	murA	1028826..1030097 (-)	1272	WP_041827046.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
H0507_RS05500 (STHERMO_1197)	-	1030167..1030403 (-)	237	WP_002946959.1	DUF1146 family protein	-
H0507_RS05505 (STHERMO_1198)	galE	1030591..1031604 (-)	1014	WP_011227279.1	UDP-glucose 4-epimerase GalE	-
H0507_RS05510 (STHERMO_1199)	-	1031619..1032074 (-)	456	WP_041827047.1	DUF4832 domain-containing protein	-

Sequence

Protein

• Length: 293 a.a.
• Molecular weight: 31757.50 Da
• Isoelectric Point: 10.1789

>NTDB_id=1130617 H0507_RS05485 WP_011226089.1 1027693..1028574(-) (endA) [Streptococcus thermophilus isolate STH_CIRM_29]
MAKRKTSLTNKQKRQLVTLIIAALIAVLGYLGTSNKLSPDNPIRQVASLVAGKSNKSIKSNGSTNSQSTPQEQLAETVMT
SSVKSQLGNSLEWNGAGAYIINRNKTNLNAKVSSQPYANNQVKTVQGQTVPTVANALLSKATRQYKNRQETGNGSTSWTP
AGWHQVQNLSGEYSHAVDRGHLLGYALIGGLKGFDASTSNPENIAVQTAWANQAYSDSSTGQNYYESLVRKALDKNKRVR
YRVTLIYEGENLIPSGTHLEAKSADGSLEFNVFVPNVQEGITLDYYSGKVTVN

Nucleotide

• Length: 882 bp

>NTDB_id=1130617 H0507_RS05485 WP_011226089.1 1027693..1028574(-) (endA) [Streptococcus thermophilus isolate STH_CIRM_29]
ATGGCAAAAAGAAAGACATCTTTGACAAATAAACAGAAACGTCAGTTAGTCACATTAATAATAGCAGCTTTGATAGCTGT
TTTAGGTTACCTAGGAACCAGTAACAAGCTCTCGCCTGATAATCCTATCAGACAAGTAGCAAGCCTAGTTGCAGGGAAAT
CTAACAAATCCATTAAATCTAATGGTTCAACAAATAGTCAGTCTACACCACAAGAGCAGCTTGCTGAGACAGTAATGACT
AGTTCAGTCAAAAGCCAACTGGGTAATTCCTTGGAATGGAATGGAGCTGGGGCCTACATTATTAATAGAAATAAGACGAA
TCTAAATGCTAAGGTATCAAGCCAACCCTATGCTAATAACCAAGTCAAAACGGTTCAAGGACAAACTGTTCCTACAGTTG
CTAATGCCTTATTAAGTAAAGCAACTAGACAGTACAAAAATCGTCAAGAAACAGGGAATGGTTCAACCTCTTGGACACCA
GCTGGATGGCACCAGGTTCAAAATTTATCAGGAGAGTATAGCCATGCCGTAGATAGAGGCCATTTGCTAGGTTATGCACT
GATAGGTGGTTTGAAAGGATTTGATGCCTCGACTTCAAATCCAGAGAATATTGCTGTTCAAACTGCTTGGGCAAATCAAG
CATATAGCGATAGTTCTACAGGCCAAAACTATTATGAAAGCCTAGTACGAAAAGCCCTGGATAAAAACAAACGTGTTCGT
TATCGTGTGACCCTGATTTATGAAGGAGAGAATCTCATTCCATCAGGAACACATCTTGAAGCTAAGTCAGCAGACGGCTC
ACTTGAGTTTAATGTCTTTGTTCCAAATGTACAAGAGGGAATTACACTAGATTACTATTCAGGAAAAGTAACGGTGAATT
GA

Domains

Predicted by InterproScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (101-266)

3D structure

• AlphaFold DB: Q5M441

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	72.803	81.57	0.594
endA	Streptococcus pneumoniae D39	72.803	81.57	0.594
endA	Streptococcus pneumoniae R6	72.803	81.57	0.594
endA	Streptococcus pneumoniae TIGR4	72.803	81.57	0.594