Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   H0503_RS01595 Genome accession   NZ_LR822009
Coordinates   299025..300542 (+) Length   505 a.a.
NCBI ID   WP_014607970.1    Uniprot ID   A0A2H4K9K6
Organism   Streptococcus thermophilus isolate STH_CIRM_19     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 294025..305542
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H0503_RS09710 - 294305..294475 (+) 171 Protein_274 ascorbate 6-phosphate lactonase -
  H0503_RS01570 (STHERMO_0336) - 294492..295163 (-) 672 WP_002946492.1 potassium channel family protein -
  H0503_RS01575 (STHERMO_0337) - 295203..296567 (-) 1365 WP_269473133.1 TrkH family potassium uptake protein -
  H0503_RS01580 (STHERMO_0338) rsmG 296637..297350 (-) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  H0503_RS01585 (STHERMO_0339) - 297647..298183 (+) 537 WP_002946488.1 DUF177 domain-containing protein -
  H0503_RS01590 (STHERMO_0340) covR 298339..299028 (+) 690 WP_002949638.1 response regulator transcription factor Regulator
  H0503_RS01595 (STHERMO_0341) covS 299025..300542 (+) 1518 WP_014607970.1 HAMP domain-containing histidine kinase Regulator
  H0503_RS01600 (STHERMO_0342) nrdR 300664..301143 (+) 480 WP_002949642.1 transcriptional regulator NrdR -
  H0503_RS01605 (STHERMO_0343) - 301140..302315 (+) 1176 WP_002949643.1 DnaD domain protein -
  H0503_RS01610 (STHERMO_0344) dnaI 302319..303221 (+) 903 WP_002946786.1 primosomal protein DnaI -
  H0503_RS01615 (STHERMO_0345) der 303327..304637 (+) 1311 WP_179970760.1 ribosome biogenesis GTPase Der -
  H0503_RS01620 - 304701..305369 (+) 669 Protein_285 HI_0552 family protein -

Sequence

Protein


Download         Length: 505 a.a.        Molecular weight: 57550.96 Da        Isoelectric Point: 5.2689

>NTDB_id=1130542 H0503_RS01595 WP_014607970.1 299025..300542(+) (covS) [Streptococcus thermophilus isolate STH_CIRM_19]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSIYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide


Download         Length: 1518 bp        

>NTDB_id=1130542 H0503_RS01595 WP_014607970.1 299025..300542(+) (covS) [Streptococcus thermophilus isolate STH_CIRM_19]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTATCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(384-494)

ArlS sensor domain (ArlS_N)

(39-187)

His Kinase A (phospho-acceptor) domain (HisKA)

(270-329)

HAMP domain (HAMP)

(213-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2H4K9K6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Streptococcus salivarius strain HSISS4

94.422

99.406

0.939

Multiple sequence alignment