Detailed information NTG1129561

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: GPW68_RS08650
• Genome accession: NZ_LR738723
• Coordinates: 1726210..1727259 (-)
• Length: 349 a.a.
• NCBI ID: WP_012775295.1
• Uniprot ID: A0A2K1T047
• Organism: Streptococcus suis isolate GD-0088
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1721210..1732259

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GPW68_RS08625	nadE	1721671..1722495 (+)	825	WP_004194617.1	ammonia-dependent NAD(+) synthetase	-
GPW68_RS08635	-	1723736..1724263 (-)	528	WP_012027591.1	VanZ family protein	-
GPW68_RS08640	rlmN	1724260..1725372 (-)	1113	Protein_1641	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
GPW68_RS08645	-	1725381..1726022 (-)	642	WP_024382386.1	YutD family protein	-
GPW68_RS08650	sepM	1726210..1727259 (-)	1050	WP_012775295.1	SepM family pheromone-processing serine protease	Regulator
GPW68_RS08655	coaD	1727246..1727734 (-)	489	WP_002939048.1	pantetheine-phosphate adenylyltransferase	-
GPW68_RS08660	rsmD	1727724..1728263 (-)	540	WP_014638485.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
GPW68_RS08665	-	1728573..1729295 (-)	723	WP_024405569.1	hypothetical protein	-
GPW68_RS08670	-	1729352..1729738 (-)	387	WP_004194735.1	rhodanese-like domain-containing protein	-
GPW68_RS08675	-	1729738..1729956 (-)	219	WP_024405570.1	YqgQ family protein	-
GPW68_RS08680	-	1730264..1730866 (-)	603	WP_024405571.1	response regulator transcription factor	-
GPW68_RS08685	-	1730980..1731957 (-)	978	WP_232053553.1	sensor histidine kinase	-

Sequence

Protein

• Length: 349 a.a.
• Molecular weight: 37761.83 Da
• Isoelectric Point: 4.6112

>NTDB_id=1129561 GPW68_RS08650 WP_012775295.1 1726210..1727259(-) (sepM) [Streptococcus suis isolate GD-0088]
MKKNRKLTLIASIVLGTLLIWFAVFVRLPYYLESPGGAADIRQVLTVNNQIDQEDGSYNFTYVSVQQATALQLFAAQFDP
YTTVRSSEEMTGGADNEEYFRIARFYMETSQNMAKYQGLTLAGKEVNLDFFGVYVLALTDDSTFKKVLNIADTVVSINGK
TFESSPDLIKYVSGLEVGSDVTVGYISAGQEKSADGKIIKLSNGKNGIGITLVDHTEVQSSIPIDFQTGDIGGPSAGLMF
TLAIYTQLAEPDLRDGRIIAGTGTIEQDGKVGDIGGADKKVISAAKSGASIFFVPNNPVDVEVLKKNPKAKTNYEEAKEA
AEKAGLDIEVVPVKTVQEAIDYLKKTKGE

Nucleotide

• Length: 1050 bp

>NTDB_id=1129561 GPW68_RS08650 WP_012775295.1 1726210..1727259(-) (sepM) [Streptococcus suis isolate GD-0088]
ATGAAGAAAAATAGGAAGTTAACCTTAATTGCATCTATTGTTTTAGGAACTCTTTTGATTTGGTTTGCCGTTTTTGTTCG
TCTGCCTTATTATCTGGAAAGTCCAGGTGGAGCTGCCGATATTCGTCAGGTACTAACGGTGAACAATCAAATAGACCAAG
AGGATGGCTCTTACAACTTCACCTATGTATCAGTCCAACAGGCTACAGCTTTACAACTATTCGCTGCTCAGTTTGATCCC
TATACGACAGTTCGTTCCTCTGAAGAGATGACAGGAGGGGCCGACAATGAGGAGTATTTCCGTATAGCACGGTTTTACAT
GGAGACATCGCAAAATATGGCGAAGTACCAAGGTTTGACCTTGGCAGGAAAAGAAGTCAATCTTGATTTCTTTGGTGTCT
ATGTGCTTGCCTTGACGGATGATTCAACCTTTAAAAAAGTTCTTAATATTGCCGACACTGTTGTGAGTATCAATGGAAAA
ACATTTGAGTCTTCTCCTGATTTGATTAAATATGTGAGTGGCTTGGAGGTTGGAAGTGATGTAACAGTTGGTTATATTAG
CGCTGGTCAGGAAAAATCTGCGGACGGTAAGATTATCAAATTGTCTAATGGCAAAAACGGGATAGGTATCACTCTCGTAG
ATCATACAGAGGTTCAAAGTTCGATTCCGATTGATTTCCAAACAGGAGATATTGGTGGTCCAAGTGCTGGTCTGATGTTT
ACACTTGCCATCTATACTCAACTCGCAGAGCCTGACTTACGTGATGGTCGGATTATTGCTGGTACGGGGACTATCGAGCA
GGATGGAAAAGTAGGTGACATTGGTGGGGCTGATAAGAAGGTCATTTCGGCAGCTAAGTCTGGTGCAAGTATCTTTTTTG
TACCAAACAATCCAGTTGATGTAGAAGTTTTGAAGAAAAATCCAAAGGCTAAAACGAACTATGAAGAAGCTAAGGAAGCA
GCCGAGAAAGCAGGTCTAGATATTGAGGTAGTTCCTGTGAAAACTGTTCAAGAGGCTATTGATTATTTGAAGAAAACAAA
GGGCGAGTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (132-195)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (232-315)

3D structure

• AlphaFold DB: A0A2K1T047

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	60.807	99.427	0.605