Detailed information NTG1129387

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: GPW48_RS02175
• Genome accession: NZ_LR738720
• Coordinates: 410472..411521 (+)
• Length: 349 a.a.
• NCBI ID: WP_012775295.1
• Uniprot ID: A0A2K1T047
• Organism: Streptococcus suis isolate GD-0001
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 405472..416521

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GPW48_RS02140	-	405774..406712 (+)	939	WP_232049074.1	sensor histidine kinase	-
GPW48_RS02145	-	406865..407467 (+)	603	WP_024405571.1	response regulator transcription factor	-
GPW48_RS02150	-	407775..407993 (+)	219	WP_024405570.1	YqgQ family protein	-
GPW48_RS02155	-	407993..408379 (+)	387	WP_004194735.1	rhodanese-like domain-containing protein	-
GPW48_RS02160	-	408436..409158 (+)	723	WP_024405569.1	hypothetical protein	-
GPW48_RS02165	rsmD	409468..410007 (+)	540	WP_014638485.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
GPW48_RS02170	coaD	409997..410485 (+)	489	WP_002939048.1	pantetheine-phosphate adenylyltransferase	-
GPW48_RS02175	sepM	410472..411521 (+)	1050	WP_012775295.1	SepM family pheromone-processing serine protease	Regulator
GPW48_RS02180	-	411709..412350 (+)	642	WP_024382386.1	YutD family protein	-
GPW48_RS02185	rlmN	412359..413471 (+)	1113	WP_012028433.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
GPW48_RS02190	-	413468..413995 (+)	528	WP_012027591.1	VanZ family protein	-
GPW48_RS02200	nadE	415291..416115 (-)	825	WP_004194617.1	ammonia-dependent NAD(+) synthetase	-

Sequence

Protein

• Length: 349 a.a.
• Molecular weight: 37761.83 Da
• Isoelectric Point: 4.6112

>NTDB_id=1129387 GPW48_RS02175 WP_012775295.1 410472..411521(+) (sepM) [Streptococcus suis isolate GD-0001]
MKKNRKLTLIASIVLGTLLIWFAVFVRLPYYLESPGGAADIRQVLTVNNQIDQEDGSYNFTYVSVQQATALQLFAAQFDP
YTTVRSSEEMTGGADNEEYFRIARFYMETSQNMAKYQGLTLAGKEVNLDFFGVYVLALTDDSTFKKVLNIADTVVSINGK
TFESSPDLIKYVSGLEVGSDVTVGYISAGQEKSADGKIIKLSNGKNGIGITLVDHTEVQSSIPIDFQTGDIGGPSAGLMF
TLAIYTQLAEPDLRDGRIIAGTGTIEQDGKVGDIGGADKKVISAAKSGASIFFVPNNPVDVEVLKKNPKAKTNYEEAKEA
AEKAGLDIEVVPVKTVQEAIDYLKKTKGE

Nucleotide

• Length: 1050 bp

>NTDB_id=1129387 GPW48_RS02175 WP_012775295.1 410472..411521(+) (sepM) [Streptococcus suis isolate GD-0001]
ATGAAGAAAAATAGGAAGTTAACCTTAATTGCATCTATTGTTTTAGGAACTCTTTTGATTTGGTTTGCCGTTTTTGTTCG
TCTGCCTTATTATCTGGAAAGTCCAGGTGGAGCTGCCGATATTCGTCAGGTACTAACGGTGAACAATCAAATAGACCAAG
AGGATGGCTCTTACAACTTCACCTATGTATCAGTCCAACAGGCTACAGCTTTACAACTATTCGCTGCTCAGTTTGATCCC
TATACGACAGTTCGTTCCTCTGAAGAGATGACAGGAGGGGCCGACAATGAGGAGTATTTCCGTATAGCACGGTTTTACAT
GGAGACATCGCAAAATATGGCGAAGTACCAAGGTTTGACCTTGGCAGGAAAAGAAGTCAATCTTGATTTCTTTGGTGTCT
ATGTGCTTGCCTTGACGGATGATTCAACCTTTAAAAAAGTTCTTAATATTGCCGACACTGTTGTGAGTATCAATGGAAAA
ACATTTGAGTCTTCTCCTGATTTGATTAAATATGTGAGTGGCTTGGAGGTTGGAAGTGATGTAACAGTTGGTTATATTAG
CGCTGGTCAGGAAAAATCTGCGGACGGTAAGATTATCAAATTGTCTAATGGCAAAAACGGGATAGGTATCACTCTCGTAG
ATCATACAGAGGTTCAAAGTTCGATTCCGATTGATTTCCAAACAGGAGATATTGGTGGTCCAAGTGCTGGTCTGATGTTT
ACACTTGCCATCTATACTCAACTCGCAGAGCCTGACTTACGTGATGGTCGGATTATTGCTGGTACGGGGACTATCGAGCA
GGATGGAAAAGTAGGTGACATTGGTGGGGCTGATAAGAAGGTCATTTCGGCAGCTAAGTCTGGTGCAAGTATCTTTTTTG
TACCAAACAATCCAGTTGATGTAGAAGTTTTGAAGAAAAATCCAAAGGCTAAAACGAACTATGAAGAAGCTAAGGAAGCA
GCCGAGAAAGCAGGTCTAGATATTGAGGTAGTTCCTGTGAAAACTGTTCAAGAGGCTATTGATTATTTGAAGAAAACAAA
GGGCGAGTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (132-195)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (232-315)

3D structure

• AlphaFold DB: A0A2K1T047

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	60.807	99.427	0.605