Detailed information NTG1128452

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: FQT67_RS10045
• Genome accession: NZ_LR595857
• Coordinates: 2013425..2015869 (-)
• Length: 814 a.a.
• NCBI ID: WP_046177491.1
• Uniprot ID: A0A9X9R4E8
• Organism: Streptococcus sp. NCTC 11567 strain NCTC11567
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	2011296..2023802	2013425..2015869	within	0

Gene organization within MGE regions

Location: 2011296..2023802

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FQT67_RS10035 (NCTC11567_02079)	groL	2011296..2012921 (-)	1626	WP_012767614.1	chaperonin GroEL	-
FQT67_RS10040 (NCTC11567_02080)	groES	2012957..2013247 (-)	291	WP_003054738.1	co-chaperone GroES	-
FQT67_RS10045 (NCTC11567_02081)	clpC	2013425..2015869 (-)	2445	WP_046177491.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
FQT67_RS10050 (NCTC11567_02082)	-	2015869..2016330 (-)	462	WP_003054759.1	CtsR family transcriptional regulator	-
FQT67_RS10055	-	2016526..2016729 (-)	204	WP_046177492.1	cold-shock protein	-
FQT67_RS10060 (NCTC11567_02084)	-	2017230..2018114 (+)	885	WP_261308909.1	amidohydrolase family protein	-
FQT67_RS10065 (NCTC11567_02085)	-	2018316..2019179 (+)	864	WP_046177583.1	IS982 family transposase	-
FQT67_RS10070 (NCTC11567_02086)	-	2019215..2019670 (+)	456	WP_046177586.1	MarR family transcriptional regulator	-
FQT67_RS10075 (NCTC11567_02087)	-	2019675..2021096 (-)	1422	WP_143936423.1	IS1182 family transposase	-
FQT67_RS10080 (NCTC11567_02088)	-	2021120..2021380 (-)	261	Protein_1936	DUF4355 domain-containing protein	-
FQT67_RS10835 (NCTC11567_02089)	-	2021487..2021657 (-)	171	WP_172601566.1	hypothetical protein	-
FQT67_RS10085 (NCTC11567_02090)	-	2021648..2021881 (-)	234	WP_046177129.1	hypothetical protein	-
FQT67_RS10090 (NCTC11567_02091)	-	2021934..2022353 (-)	420	WP_046177130.1	HD domain-containing protein	-
FQT67_RS10095 (NCTC11567_02092)	-	2022350..2022556 (-)	207	WP_003052398.1	hypothetical protein	-
FQT67_RS10100 (NCTC11567_02093)	-	2022558..2023802 (-)	1245	WP_046177131.1	phage head morphogenesis protein	-

Sequence

Protein

• Length: 814 a.a.
• Molecular weight: 90335.98 Da
• Isoelectric Point: 6.6501

>NTDB_id=1128452 FQT67_RS10045 WP_046177491.1 2013425..2015869(-) (clpC) [Streptococcus sp. NCTC 11567 strain NCTC11567]
MIMYSLKMQEIFRQAQFQAARFDSQYLETWHILLAMARVDHSLAGLVLSEFDAKVAVEEYEAAAILAMGKSPKYQVSHID
FRPQSKTLTNLLQFAQAISQVTKDQEVGSEHVLFAILLNPDIMATRLLEMAGYTIKDKGNGEPRLADLRKAIEIHAGYSK
EIIKAIHELRKPKKTKNQGSFSDMMKPPSTAGDLADFTRDLTEMASQGLLEPVIGRDAEVSRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIANGVIPYELQDMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIESDGKIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNVEDAYQILLGLKGSYETYHNVTIAN
QAVRTAVKMAHRYLTSKNLPDSAIDLLDEASATVQGMVKKSTPEIITPLDQALIDGDMKKASRLLAKDVKGQHRKPTAVT
EEDILTTLSKLSGIPLEKLSQADSKKYLNLEKELHKRVIGQEDAVSAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDASALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGMLTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKGISHDHQAMEKRILEELKKAYRPEFINRIDEKVVFH
SLTQDNMREVVKIIVQPLMATLAEKGITLKFQPMALKYLSEEGYDVEMGARPLRRTLQTQVEDKLSELILAGELASGHTL
KIGLSHGKLSFNLE

Nucleotide

• Length: 2445 bp

>NTDB_id=1128452 FQT67_RS10045 WP_046177491.1 2013425..2015869(-) (clpC) [Streptococcus sp. NCTC 11567 strain NCTC11567]
ATGATCATGTATTCATTGAAGATGCAAGAAATTTTCAGGCAGGCGCAGTTTCAAGCAGCCCGCTTTGATAGCCAATATCT
AGAAACTTGGCATATATTGCTAGCTATGGCGAGGGTTGATCACTCCCTAGCGGGTTTGGTGCTAAGCGAATTTGATGCTA
AGGTTGCAGTGGAAGAATATGAGGCTGCAGCTATTTTAGCGATGGGCAAAAGTCCTAAATACCAAGTGTCTCACATTGAC
TTTAGGCCTCAGTCAAAAACCTTAACGAACCTTTTGCAATTTGCCCAAGCTATCAGTCAAGTCACCAAAGACCAAGAGGT
AGGTTCAGAGCATGTTCTCTTTGCCATTTTGCTTAATCCAGATATTATGGCGACTCGCTTATTAGAGATGGCGGGTTATA
CTATCAAGGATAAAGGAAACGGGGAGCCTCGCTTAGCTGATTTACGAAAAGCTATCGAGATTCATGCAGGCTATAGCAAG
GAAATAATTAAGGCTATCCACGAGTTGCGTAAGCCAAAGAAAACCAAAAATCAAGGTTCTTTTTCAGACATGATGAAGCC
ACCAAGCACGGCTGGGGACTTGGCGGACTTTACACGTGATTTGACCGAGATGGCAAGCCAAGGTCTCTTAGAGCCAGTTA
TTGGCCGTGATGCTGAAGTGTCACGGATGATTCAAGTACTGAGTCGTAAAACAAAGAATAACCCTGTTCTTGTGGGTGAT
GCAGGTGTGGGTAAAACGGCCCTTGCCTACGGCCTAGCCCAACGTATTGCTAATGGTGTTATTCCTTATGAGCTGCAAGA
CATGCGTGTTCTAGAATTAGACATGATGAGTGTTGTTGCGGGGACCCGTTTTCGTGGGGATTTTGAAGAGCGCATGAATC
AAATCATTGACGATATTGAGTCAGATGGCAAAATTATTCTCTTCGTAGATGAATTGCACACCATTATGGGATCAGGAAGT
GGTATTGATAGCACGCTTGATGCTGCCAATATTTTAAAACCAGCCTTATCTCGTGGAACCCTCCATATGGTGGGTGCAAC
AACGCAGGAAGAATACCAAAAACACATTGAAAAAGATGCCGCTCTTTCGCGCCGCTTTGCTAAGATTTTAATTGAAGAAC
CTAATGTAGAAGATGCTTATCAGATTCTGCTAGGACTAAAAGGCTCTTACGAGACTTACCATAATGTGACCATTGCTAAT
CAGGCTGTTAGAACCGCTGTGAAAATGGCACATCGCTATCTGACCAGCAAAAACCTTCCGGATTCTGCCATTGATTTGTT
GGATGAAGCCAGTGCTACAGTGCAAGGTATGGTTAAAAAATCTACGCCAGAAATCATCACGCCATTAGATCAAGCTTTGA
TTGATGGCGATATGAAGAAGGCCTCTCGTTTGTTGGCAAAAGACGTTAAAGGGCAACATCGCAAGCCAACAGCTGTGACA
GAAGAGGACATCCTGACGACCTTGAGCAAGCTATCAGGTATTCCACTGGAAAAACTCAGCCAAGCTGATAGCAAAAAATA
CCTTAATTTGGAAAAAGAACTGCATAAGCGCGTGATTGGGCAAGAAGATGCTGTCTCAGCTATTTCTAGAGCCATTCGCC
GTAATCAGTCAGGCATTCGTACAGGTAAACGTCCAATCGGTTCTTTCATGTTCCTTGGTCCAACAGGGGTTGGTAAGACC
GAGTTGGCAAAAGCCTTGGCAGAAGTTCTCTTTGATGACGCGTCCGCCCTTATCCGCTTTGATATGTCAGAGTATATGGA
GAAATTTGCGGCTTCTCGCCTTAATGGCGCACCTCCAGGCTATGTTGGTTACGATGAAGGTGGTGAATTAACAGAGAAGG
TCAGAAACAAGCCTTATTCTGTGCTCCTCTTTGACGAGGTGGAAAAAGCTCACCCTGATATTTTCAACGTCCTCTTACAA
GTGCTTGATGATGGCATGTTGACAGATAGCCGTGGGCGTAAAGTGGACTTCTCAAATACCATTATTATCATGACAAGTAA
TCTAGGGGCAACAGCTCTGCGTGATGATAAAACAGTTGGCTTTGGGGCAAAAGGCATTAGCCATGACCACCAAGCCATGG
AAAAACGGATTTTGGAAGAGTTGAAAAAAGCTTACCGACCAGAATTTATCAACCGAATTGATGAAAAGGTTGTCTTCCAC
AGCCTCACTCAGGACAATATGAGAGAAGTAGTCAAGATTATAGTGCAGCCGTTGATGGCTACTTTGGCAGAAAAAGGCAT
TACCCTCAAATTCCAGCCAATGGCCCTCAAGTATTTATCAGAAGAAGGGTATGATGTGGAAATGGGTGCTCGTCCATTAC
GCCGCACTTTGCAAACTCAGGTGGAAGATAAATTGTCTGAATTGATTCTTGCTGGTGAATTGGCAAGTGGTCATACCCTG
AAAATTGGCCTTTCTCATGGAAAACTCAGCTTTAACCTTGAGTGA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (376-462)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (15-53)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-137)

• ATPase family associated with various cellular activities (AAA) (AAA) (236-368)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (722-801)

• AAA domain (Cdc48 subfamily) (AAA_2) (544-715)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	76.261	99.877	0.762
clpC	Streptococcus thermophilus LMG 18311	72.672	100	0.729
clpC	Streptococcus thermophilus LMD-9	72.672	100	0.729
clpC	Streptococcus pneumoniae TIGR4	67.036	99.877	0.67
clpC	Streptococcus pneumoniae Rx1	67.036	99.877	0.67
clpC	Streptococcus pneumoniae D39	67.036	99.877	0.67
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48.561	100	0.498
clpC	Bacillus subtilis subsp. subtilis str. 168	42.668	100	0.436