Detailed information NTG1127054

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: FGK91_RS06195
• Genome accession: NZ_LR590483
• Coordinates: 1207593..1208630 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC8318
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1202593..1213630

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGK91_RS06175 (NCTC8318_01233)	-	1203343..1203969 (+)	627	WP_023079342.1	A24 family peptidase	-
FGK91_RS06180 (NCTC8318_01234)	rlmN	1204051..1205130 (-)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
FGK91_RS06185 (NCTC8318_01235)	-	1205134..1205754 (-)	621	WP_023079340.1	YutD family protein	-
FGK91_RS06190 (NCTC8318_01237)	-	1206202..1207179 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
FGK91_RS06195 (NCTC8318_01238)	sepM	1207593..1208630 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
FGK91_RS06200 (NCTC8318_01239)	coaD	1208617..1209108 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
FGK91_RS06205 (NCTC8318_01240)	rsmD	1209098..1209637 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
FGK91_RS06210 (NCTC8318_01241)	asnA	1209760..1210752 (-)	993	WP_010922500.1	aspartate--ammonia ligase	-
FGK91_RS06215 (NCTC8318_01242)	arcC	1211065..1212015 (-)	951	WP_010922501.1	carbamate kinase	-
FGK91_RS06220 (NCTC8318_01243)	-	1212035..1213366 (-)	1332	WP_115224608.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1127054 FGK91_RS06195 WP_010922499.1 1207593..1208630(-) (sepM) [Streptococcus pyogenes strain NCTC8318]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1127054 FGK91_RS06195 WP_010922499.1 1207593..1208630(-) (sepM) [Streptococcus pyogenes strain NCTC8318]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693