Detailed information NTG1126865

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: FGK94_RS03500
• Genome accession: NZ_LR590471
• Coordinates: 760595..761632 (-)
• Length: 345 a.a.
• NCBI ID: WP_014622492.1
• Uniprot ID: A0A6D2LSH8
• Organism: Streptococcus equi subsp. zooepidemicus strain NCTC11854
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 755595..766632

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGK94_RS03475 (NCTC11854_00719)	-	755877..756110 (-)	234	WP_012515231.1	YqgQ family protein	-
FGK94_RS03480 (NCTC11854_00720)	-	756483..757013 (-)	531	WP_012515230.1	Dps family protein	-
FGK94_RS03490 (NCTC11854_00722)	rlmN	758285..759367 (-)	1083	WP_043029472.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
FGK94_RS03495 (NCTC11854_00723)	-	759371..759985 (-)	615	WP_012678319.1	YutD family protein	-
FGK94_RS03500 (NCTC11854_00724)	sepM	760595..761632 (-)	1038	WP_014622492.1	SepM family pheromone-processing serine protease	Regulator
FGK94_RS03505 (NCTC11854_00725)	coaD	761610..762110 (-)	501	WP_014622491.1	pantetheine-phosphate adenylyltransferase	-
FGK94_RS03510 (NCTC11854_00726)	rsmD	762100..762639 (-)	540	WP_014622490.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
FGK94_RS03515 (NCTC11854_00727)	asnA	762809..763801 (-)	993	WP_012515219.1	aspartate--ammonia ligase	-
FGK94_RS03520 (NCTC11854_00728)	arcC	764021..764971 (-)	951	WP_043029469.1	carbamate kinase	-
FGK94_RS03525 (NCTC11854_00729)	-	764989..766320 (-)	1332	WP_043029468.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37450.05 Da
• Isoelectric Point: 9.2833

>NTDB_id=1126865 FGK94_RS03500 WP_014622492.1 760595..761632(-) (sepM) [Streptococcus equi subsp. zooepidemicus strain NCTC11854]
MKTIKKFKWWLIGFVALLFLLLTLFFPLPYYIEMPGGAYDIRSVLTVNGKEDKEKGAYQFVVVSLSRATLAKLLYAWLTP
FTEISTMEDTTGGYSDADYLRINRFYMETSQNSAVYQALTLAGKEVSFDYKGVYVLDVSKDSSFKGVLHLADTVTGVNGK
TFTTSADLIDYVSHLTLGDEVQVQFTTAGESKTEKGKIIKLKNGKNGIGITLTDHTQVISGDEVDFSTGGVGGPSAGLMF
TLDIYDQINHEDLRKGRVIAGTGTIGKDGKVGDIGGAGLKVAAAAAAGADIFFVPNNPVDKDVKKANPKAISNYEEAKKA
AKRLKTAMKIIPVKTVQDAISYLKK

Nucleotide

• Length: 1038 bp

>NTDB_id=1126865 FGK94_RS03500 WP_014622492.1 760595..761632(-) (sepM) [Streptococcus equi subsp. zooepidemicus strain NCTC11854]
ATGAAAACAATAAAAAAATTTAAATGGTGGCTGATTGGCTTTGTTGCCTTGCTTTTTCTACTGTTGACACTGTTTTTCCC
CTTGCCTTATTATATTGAAATGCCAGGTGGAGCCTATGATATTCGCTCGGTATTGACTGTCAATGGCAAAGAGGATAAGG
AAAAGGGAGCTTATCAGTTTGTTGTAGTGAGCCTCAGTCGGGCCACCTTGGCTAAATTGCTCTATGCTTGGCTAACGCCT
TTCACTGAGATTAGCACCATGGAAGATACTACTGGTGGCTATAGCGATGCTGACTACCTGCGAATTAATCGCTTTTATAT
GGAAACCTCTCAAAACAGCGCTGTTTATCAGGCCCTTACTCTAGCAGGCAAGGAGGTAAGCTTTGATTATAAGGGTGTTT
ATGTCTTAGACGTCAGCAAGGATTCTAGCTTTAAAGGTGTGCTGCACCTAGCAGATACAGTGACAGGTGTCAATGGTAAA
ACATTTACAACGTCTGCCGATCTGATTGATTATGTTTCTCATTTGACCTTGGGAGATGAGGTGCAGGTACAATTTACAAC
CGCTGGTGAGTCAAAGACTGAAAAAGGAAAGATTATTAAGCTTAAAAACGGTAAAAATGGGATTGGCATTACCCTGACAG
ACCACACACAGGTCATTTCTGGTGATGAGGTCGACTTTAGCACCGGAGGTGTGGGTGGACCAAGTGCAGGCTTGATGTTT
ACTCTTGATATTTATGATCAAATCAATCACGAAGACTTGCGCAAGGGACGTGTGATTGCTGGTACAGGAACCATTGGCAA
GGATGGAAAAGTTGGAGATATTGGCGGGGCGGGCCTAAAGGTGGCTGCCGCCGCCGCTGCTGGTGCTGATATTTTCTTTG
TTCCAAATAATCCTGTGGATAAGGACGTCAAAAAAGCAAATCCTAAGGCCATTAGCAATTACGAGGAGGCTAAAAAAGCA
GCTAAACGACTAAAGACAGCAATGAAAATTATTCCTGTGAAAACCGTTCAAGATGCTATAAGCTACCTTAAAAAATAG

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-311)

3D structure

• AlphaFold DB: A0A6D2LSH8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	70.145	100	0.701