Detailed information NTG1126777

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: FGK81_RS03265
• Genome accession: NZ_LR590466
• Coordinates: 645860..646897 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NCTC8193
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 640860..651897

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGK81_RS03240 (NCTC8193_00641)	-	641124..642455 (+)	1332	WP_011888730.1	dipeptidase	-
FGK81_RS03245 (NCTC8193_00642)	arcC	642475..643425 (+)	951	WP_011528820.1	carbamate kinase	-
FGK81_RS03250 (NCTC8193_00643)	asnA	643738..644730 (+)	993	WP_011888731.1	aspartate--ammonia ligase	-
FGK81_RS03255 (NCTC8193_00644)	rsmD	644853..645392 (+)	540	WP_011888732.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
FGK81_RS03260 (NCTC8193_00645)	coaD	645382..645873 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
FGK81_RS03265 (NCTC8193_00646)	sepM	645860..646897 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
FGK81_RS03270 (NCTC8193_00647)	-	647309..648286 (+)	978	WP_002989070.1	LacI family DNA-binding transcriptional regulator	-
FGK81_RS03275 (NCTC8193_00649)	-	648734..649354 (+)	621	WP_002992791.1	YutD family protein	-
FGK81_RS03280 (NCTC8193_00650)	rlmN	649358..650437 (+)	1080	WP_011184761.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
FGK81_RS03285 (NCTC8193_00651)	-	650519..651145 (-)	627	WP_011888733.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=1126777 FGK81_RS03265 WP_010922499.1 645860..646897(+) (sepM) [Streptococcus pyogenes strain NCTC8193]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=1126777 FGK81_RS03265 WP_010922499.1 645860..646897(+) (sepM) [Streptococcus pyogenes strain NCTC8193]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693