Detailed information NTG1124186

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EL299_RS08290
• Genome accession: NZ_LR134536
• Coordinates: 1688342..1689388 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain NCTC13924
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1683342..1694388

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL299_RS08260 (NCTC13924_01633)	-	1683726..1684967 (-)	1242	WP_001832467.1	aminopeptidase	-
EL299_RS08265 (NCTC13924_01634)	-	1684969..1685184 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
EL299_RS08270 (NCTC13924_01635)	-	1685325..1685789 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
EL299_RS08275 (NCTC13924_01636)	-	1685797..1686081 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
EL299_RS08280 (NCTC13924_01637)	-	1686488..1687666 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
EL299_RS08285 (NCTC13924_01638)	vraR	1687723..1688352 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
EL299_RS08290 (NCTC13924_01639)	vraS	1688342..1689388 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
EL299_RS08295 (NCTC13924_01640)	liaF	1689385..1690086 (-)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
EL299_RS08300 (NCTC13924_01641)	-	1690101..1690487 (-)	387	WP_001830382.1	hypothetical protein	-
EL299_RS08305 (NCTC13924_01642)	map	1690645..1691400 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
EL299_RS08310 (NCTC13924_01643)	-	1691574..1692560 (+)	987	WP_001830388.1	FUSC family protein	-
EL299_RS08315 (NCTC13924_01644)	isaB	1692711..1693247 (-)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=1124186 EL299_RS08290 WP_001830374.1 1688342..1689388(-) (vraS) [Staphylococcus epidermidis strain NCTC13924]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=1124186 EL299_RS08290 WP_001830374.1 1688342..1689388(-) (vraS) [Staphylococcus epidermidis strain NCTC13924]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92